Clinical trials: Toxicity
Epidemiologic Data of Some Synthetic Cannibinoids Toxicity in Patients Presenting at Assiut University Hospital, Psychiatric Hospital of Ministry of Health), Proportion of Acute and Chronic Abusers of Synthetic Cannibinoids Among Cases of Illicit Drugs Abuser in Studied Sites
Acute and Chronic Toxicity of Some Synthetic Cannabinoids in Assiut Psychiatric Hospitals
Synthetic cannabinoids (SCs) are new human-made mind-altering chemicals which are similar to chemicals found in the marijuana plant; they are recent to be used recreationally, especially by young adults.
- Trial name
- NCT03866941
- Testing
- causes of abuse synthetic cannibinoids
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Drug Toxicity, Healthy
Aminotransferase Trends During Prolonged Acetaminophen Dosing
The objective of this study is to monitor liver function tests (blood levels of an indicator of liver function) of healthy people taking the maximum labeled daily dose of acetaminophen compared to people taking placebo for 16 to…
- Trial name
- NCT00743093
- Testing
- acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Nasopharyngeal Carcinoma
Nimotuzumab Combined With VMAT in Elderly Patients With Nasopharyngeal Carcinoma
To evaluate the efficacy and toxicity of Nimotuzumab combined with VMAT in the treatment of elderly patients with nasopharyngeal carcinoma (> 70 years old), and to provide high-level clinical evidence for the optimal treatment of…
- Trial name
- NCT03915132
- Testing
- Nimotuzumab, VMAT
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Drug Toxicity, Platelet Dysfunction
The Influence of Tramadol on Platelet Function
The aim of this ex-vivo study is to quantify the effect of tramadol on platelet aggregation.
- Conditions
- Drug Toxicity, Platelet Dysfunction, Clotting Disorder
- Trial name
- NCT05237492
- Testing
- Tramadol
- Where
- Austria
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Glucocorticoids Toxicity, COVID-19
Study to Evaluate Pharmacokinetics, Safety & Tolerability of 101-PGC-005 in Healthy, Adult, Human Subjects
The goal of this interventional study is to evaluate the pharmacokinetics, safety, and tolerability of 101-PGC-005 in healthy, adult, human subjects.
- Conditions
- Glucocorticoids Toxicity, COVID-19, Infectious Disease, Virus Diseases
- Trial name
- NCT05619770
- Testing
- 101-PGC-005
- Where
- India
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- 101 Therapeutics
Oxygen Toxicity, Oxygen Deficiency
Supplementary Oxygen in Surgical and Medical Wards Evaluated by 30-day Mortality
This study evaluates the use and effects of supplementary oxygen in surgical and medical wards on patients admitted to a hospital in the capital region of Denmark.
- Trial name
- SOSAM (NCT03625700)
- Testing
- Oxygen gas
- Where
- Denmark
- Volunteers
- 11,196 people, healthy volunteers welcome
- Sponsor
- Hannibal Troensegaard
Healthy
Safety and PK of Nikkomycin Z in Healthy Subjects
The purpose of this study is to determine if nikkomycin Z is safe when administered at different dose levels for 14 days. The study will also determine blood levels and urinary excretion of nikkomycin Z in relation to dose…
- Trial name
- NCT00834184
- Testing
- nikkomycin Z
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Neuroendocrine Tumors, Heart Failure
Phase I Study of the Safety, Distribution, and Radiation Dosimetry of Ultratrace Iobenguane 123I-mIBG
The goal of this proposal is to produce and test high specific activity Ultratrace iobenguane I 123 in normal human volunteers.
- Trial name
- mIBG (NCT01730417)
- Testing
- no carrier added metaiodobenzylguanidine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bennett Chin
Renal Impairment, Gout
Evaluation of Colchicine and Nonsteroidal Anti-inflammatory Drug Combination Therapy and Renal Function in Gout Patients
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment…
- Conditions
- Renal Impairment, Gout, Colchicine Adverse Reaction, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT05006001
- Testing
- Colchicine and NSAID
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- En Chu Kong Hospital
Myocardial Fibrosis, Myocardial Injury
Myocardial Perfusion and Fibrosis in Cancer Survivors
This is a cross-sectional pilot study. The investigators seek to obtain early information pertaining to the relationship between measurements of myocardial perfusion reserve and myocardial fibrosis after receipt of…
- Conditions
- Myocardial Fibrosis, Myocardial Injury, Chemotherapeutic Toxicity
- Trial name
- NCT03191461
- Testing
- Adenosine stress test MRI
- Where
- 2 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Heated Tobacco, Respiratory Function
Acute Effects of a Heat-not-burn Tobacco Product on Pulmonary Function in Healthy Non Smokers.
IQOS ("I-Quit-Ordinary-Smoking,") is a type of "heat-not-burn" (HNB) tobacco product. There is evidence of a growing number of young people who try IQOS as a 'safe' alternative of cigarette.
- Conditions
- Heated Tobacco, Respiratory Function, Tobacco Toxicity
- Trial name
- NCT03995329
- Testing
- IQOS
- Where
- 2 sites in Greece
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Drug Toxicity
Phase I Clinical Study of Soy Isoflavones in Healthy, Post-Menopausal Women
The purpose of this research study is to examine the safety of specific soy components, known as isoflavones, and to find out what effects (good and bad) these components have on tissues that are sensitive to the hormone estrogen…
- Trial name
- NCT00491595
- Testing
- High Dose Soy isoflavones
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Healthy
Phase 1B Study of RiVax, a Vaccine to Prevent the Toxic Effects of Ricin
Dose escalation study: 3 dose groups. 5 patients in each dose group, then 15 more patients in "best" group. 3 vaccinations in volunteers, at 0 6 and 16 weeks.
- Trial name
- FDA-OPD (NCT00812071)
- Testing
- RiVax
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Asthma, Hypertension
World Trade Center Adolescent Health Study
The proposed study builds upon preliminary studies in self-selected populations to identify opportunities for early identification of World Trade Center-related health consequences in adolescents.
- Conditions
- Asthma, Hypertension, Cardiovascular Risk Factor, Insulin Resistance
- Trial name
- NCT02068183
- Where
- United States
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Toxic-Shock Syndrome, Sepsis
Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- NCT02971670
- Testing
- rTSST-1 Variant Candidate Vaccine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Response to Toxin, Toxicity
Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal Cancer
The investigators compare two-week course of chemoradiation (33 Gy in 10 fractions with oral capecitabine) and conventional chemoradiation (50.4 Gy in 28 fractions with 5-FU and leucovorin) in this randomized trial.
- Conditions
- Response to Toxin, Toxicity, Recurrence
- Trial name
- NCT02484040
- Testing
- Two-week course of radiation
- Where
- South Korea
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jong Hoon Lee
Radiation Toxicity
Normal Tissue Oxygenation Following Radiotherapy
This study involves women who have had a diagnosis of breast cancer, and have had a lumpectomy with radiation treatments completed in the past year.
- Trial name
- NCT00677040
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Essentia Health
Long-term Effects Secondary to Cancer Therapy in Adults
Does Watercress Intake Have an Impact on Cancer Patients Outcomes: a Longitudinal Trial
Population studies associate a higher intake of cruciferous vegetables with a reduced risk of cancer. Studies identified PEITC and several active isothiocyanates in watercress extract that may have significant anticarcinogenic…
- Trial name
- NCT02468882
- Testing
- Watercress
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Fasting, Diet, Chemotherapy, Toxicity
Evaluation of the Influence of Short Term Fasting Diet on Chemotherapy-induced Toxicities in Breast Cancer Patients
This is a clinical trial aiming to assess the effect of fasting diet on chemotherapy - induced toxicities in breast cancer patients. The study will have an intevention group and a control group.
- Trial name
- NCT06015087
- Testing
- fasting diet
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Open Burn Pit Exposure
DNA Methylation Markers in Veterans Exposed to Open Burn Pits
Background: The VA and DoD estimate that 3.5 million Veterans and Service Members were exposed to open burn pits used for waste disposal during military deployments to countries such as Kuwait, Afghanistan, and Iraq since 1990.
- Trial name
- NCT06305091
- Testing
- Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Central Arkansas Veterans Healthcare System