Clinical trials: Toxicity
Cigarette Smoking, Smoking Behavior
Smoking Topography Study 2018
Rationale: The World Health Organization Framework Convention on Tobacco Control (WHO FCTC) aims for a regulatory strategy including the regulation of the contents of tobacco products (Article 9).
- Conditions
- Cigarette Smoking, Smoking Behavior, Cigarette Smoking Toxicity
- Trial name
- NCT03498053
- Testing
- Marlboro, Marlboro Prime, Marlboro Prime (ventilation holes taped)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Nasopharyngeal Carcinoma
Nimotuzumab Combined With VMAT in Elderly Patients With Nasopharyngeal Carcinoma
To evaluate the efficacy and toxicity of Nimotuzumab combined with VMAT in the treatment of elderly patients with nasopharyngeal carcinoma (> 70 years old), and to provide high-level clinical evidence for the optimal treatment of…
- Trial name
- NCT03915132
- Testing
- Nimotuzumab, VMAT
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Opioid Toxicity, Pupillary Miosis
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60.
- Conditions
- Opioid Toxicity, Pupillary Miosis, Respiratory Depression
- Trial name
- NCT05391555
- Testing
- Remifentanil Hydrochloride, Pupillometry measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bacterial Infections
Evaluation of Atuna Racemosa Toxicity
For thousands of years people in the South Pacific have used Atuna racemosa extract as a topical anti-inflammatory. We, the researchers at the Mayo Clinic, have shown this extract to also have antibacterial properties.
- Trial name
- NCT00318344
- Testing
- Atuna Racemosa
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HIV Infections
A Pilot Study for Toxicity Evaluation of HIV Rectal Microbicides
The purpose of this study is to determine if detectable changes in permeability of the lining of the colon are caused by either application of HIV microbicide gels or medical procedures, such as flexible sigmoidoscopy.
- Trial name
- NCT00389311
- Testing
- Normosol-R, Nonoxynol-9, Gastrointestinal instrumentation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Safety and PK of Nikkomycin Z in Healthy Subjects
The purpose of this study is to determine if nikkomycin Z is safe when administered at different dose levels for 14 days. The study will also determine blood levels and urinary excretion of nikkomycin Z in relation to dose…
- Trial name
- NCT00834184
- Testing
- nikkomycin Z
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Toxic Shock Syndrome, Vaccination; Sepsis
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- rTSST-1 (NCT02340338)
- Testing
- rTSST-1 Variant Candidate Vaccine
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Acetaminophen Toxicity
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the…
- Trial name
- APAPII (NCT02322879)
- Testing
- First Treatment Period, Washout, Second Treatment Period
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Haemodynamic Stability
Evaluation of the Role of Low Dose Magnesium Sulfate in Anesthesia for Toxic Goiter Resection
Anesthesia for toxic goiter removal is a challenging because of of hemodynamic instability especially during induction, intubation, manipulations of the gland, after removal of the gland and during emergence.
- Trial name
- Anesthesia (NCT04632524)
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Oxygen Toxicity
Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)
The purpose of this study is to understand how ketogenic food products affect oxygen toxicity in undersea divers. Oxygen toxicity affecting the central nervous system, mainly the brain, is a result of breathing higher than normal…
- Trial name
- NCT05801120
- Testing
- Ketogenic food products
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Duke University
Lead Toxicity
Iron Supplementation of Lead-exposed Infants
The purpose of this study is to compare the efficacy of iron (12.5 mg as ferrous sulfate) and placebo given for 6 months in preventing the elevation of blood lead concentration in children 6-9 months of age.
- Trial name
- NCT00374790
- Testing
- Ferrous sulfate
- Where
- Uruguay
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cornell University
HIV Infections
Natural History Study of HIV Acquired in Infancy or Childhood
Background: About 10,000 children in the United States have been living with HIV infection since birth. Little is known about the long-term effects of HIV infection and its treatment on the growth and development of these…
- Trial name
- NCT00924365
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Toxicity
Evaluating the Safety and Plasma Levels of N-Methanocarbathymidine (N-MCT) in Normal Patients
This Phase I evaluation of N-MCT in normal volunteers requires sequentially increased doses. At each dose level, the safety and pharmacokinetic will be measured.
- Trial name
- NCT02778386
- Testing
- N-Methanocarbathymidine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- N&N Pharmaceuticals Inc.
Testicular Abnominalies
Study to Evaluate the Effect of Zoliflodacin on Testicular Function in Healthy Adult Men
This study is a randomized, double-blind, placebo-controlled clinical trial to evaluate the effect of zoliflodacin on testicular function in healthy adult men.
- Trial name
- NCT07640477
- Testing
- Zoliflodacin
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Global Antibiotics Research and Development Partnership
Removal of Toxicity From Dental Bleaching
NAC Prevents Toxicity of Teeth Bleaching
Dental bleaching is a simple procedure for aesthetic restoration of vital and non-vital discolored teeth. Nevertheless, a number of studies conducted previously demonstrated the risk of tissue damage from contact of these agents…
- Trial name
- NCT03534115
- Testing
- NAC
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Financial Stress, Hematologic Cancer
Coverage and Cost of Care Links- Telehealth
The overall objective of this study is to develop and implement CC LinksTele (Coverage and Cost-of-Care Links- Telehealth)- a multilevel intervention designed to empower pediatric cancer patients, caregivers, and healthcare teams…
- Conditions
- Financial Stress, Hematologic Cancer, Survivorship
- Trial name
- CC Links- Tele (NCT07409662)
- Testing
- CC LinksTele
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Jean Edward
Overweight and Obesity, Exertion; Excess
Effects of Ketogenic Diet in Divers Breathing Enriched Air Nitrox
Overweight divers face a challenging activity such as immersions, starting from a higher levels of circulating cytokines and oxidative stress.
- Conditions
- Overweight and Obesity, Exertion; Excess, Oxygen Toxicity
- Trial name
- NCT03114176
- Testing
- Ketogenic Diet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Padova
Osteosarcoma
Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients With Osteosarcoma
The primary objectives of this trial are the determination of feasibility and toxicity of Heavy Ion Radiotherapy (C12) in patients with non-resectable osteosarcoma.
- Trial name
- NCT01005043
- Testing
- heavy ion radiotherapy (C12)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Response to Toxin, Toxicity
Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal Cancer
The investigators compare two-week course of chemoradiation (33 Gy in 10 fractions with oral capecitabine) and conventional chemoradiation (50.4 Gy in 28 fractions with 5-FU and leucovorin) in this randomized trial.
- Conditions
- Response to Toxin, Toxicity, Recurrence
- Trial name
- NCT02484040
- Testing
- Two-week course of radiation
- Where
- South Korea
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jong Hoon Lee
Pollution; Exposure
Scalability of a Home Health Navigator Program to Reduce Arsenic, Nitrate, and Lead in Private Well Water
Approximately 34 million Americans rely on private wells to supply their drinking water. Private wells are excluded from the Safe Drinking Water Act.
- Trial name
- NCT05395663
- Testing
- Community health worker
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Oregon State University