Clinical trials: Toxicity
Anesthesia, Intravenous Anesthetic Toxicity
Comparison of the Perioperative Effects of Dexmedetomidine and Ketamine Sedation in Septorhinoplasty Operations
This randomized double-blind study aimed to compare the effects of dexmedetomidine and ketamine on hemodynamic parameters, recovery criteria, and opioid consumption and advers effects in septorhinoplasty operations.
- Trial name
- NCT04628559
- Testing
- Dexmedetomidine, Ketamine, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Toxicity by Bleach
The Use of Disinfectants Among Women in Egypt and the Toxicity by Bleach During the Coronavirus Lock-down.
This study examines the use of disinfectants by Egyptian women during the coronavirus lockdown. Data will be collected via an online self-administered questionnaire that will be distributed to Egyptian women via social media…
- Trial name
- NCT04405284
- Testing
- use and exposure to disinfectants during the coronavirus pandemic
- Where
- Egypt
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Helwan University
Locally Advanced Cervical Carcinoma
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy
To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with…
- Trial name
- EROS3 (NCT06398938)
- Testing
- Interventional Radiotherapy
- Where
- Italy
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer, Radiation Dermatitis
Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
Breast cancer patients undergoing adjuvant radiotherapy commonly experience radiation-induced skin reactions which adversely impact quality of life.
- Trial name
- NCT04166799
- Testing
- Mepitel Film
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Diet Habit, Iodine Deficiency
Jodkids: a Study of Iodine Intake Among Children Aged 2-10 Years
The overall aim of the study is to monitor the effects of the increased iodine fortification level implemented in 2019 on iodine intake from the diet (incl.
- Conditions
- Diet Habit, Iodine Deficiency, Iodine Toxicity
- Trial name
- NCT06234982
- Where
- Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- DTU National Food Institute
Smoking Cessation, Toxicity
The ESTxENDS Trial- Substudy on the Effect on Toxins From Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Toxins outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612544)
- Testing
- ENDS (Vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
Inflammatory Response, Multi Organ Failure
Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients
This study will involve blood draws to test for specific cytokines. The study goal is to gain a better understanding of the role of inflammatory response in the development of specific complications in burn and TENS patients.
- Conditions
- Inflammatory Response, Multi Organ Failure, Nosocomial Infection, Deep Vein Thrombosis
- Trial name
- NCT04252651
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Joseph M. Still Research Foundation, Inc.
Xerostomia Following Radiotherapy
Treatment of Post-radiation Xerostomia With Allogeneic Mesenchymal Stromal Stem Cells
The goal of this clinical trial is to learn about toxicity of allogeneic mesenchymal stromal stem cells (MSC, derived from umbilical cord tissue) treatment in head and neck cancer patients with for post-radiation xerostomia.
- Trial name
- NCT06012604
- Testing
- allogeneic mesenchymal stromal stem cells
- Where
- 4 sites in Slovenia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
HMG-CoA Reductase Inhibitor Toxicity
Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise).
- Trial name
- NCT04636138
- Testing
- Exercise
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Preterm Birth, Premature Birth
Exposure to Plasticisers in the Neonatal Intensive Care Unit
Neonatal intensive care relies on indwelling plastic medical devices fundamental in respiratory support, intravenous catheterization, and nutrition.
- Conditions
- Preterm Birth, Premature Birth, Neurodevelopmental Disorders, Pulmonary Disease
- Trial name
- PLASTIC-NICU (NCT05404815)
- Where
- Belgium
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Heavy Metal Toxicity
Investigation of Wet Cupping Therapy on Heavy Metal Levels of Steel Industry Workers
This interventional study investigates the efficacy of Wet cupping therapy on heavy metal levels.The levels of the selected heavy metals will be measured in the blood samples obtained from the participants before and after the…
- Trial name
- NCT03693079
- Testing
- Wet cupping therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Anxiety, Surgery
Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?
Background: Anxiety is a common phenomenon in hospitalized patients. In order to reduce it during the surgical procedure, sedatives and anxiolytics are used, which can cause undesirable side effects for patients.
- Conditions
- Anxiety, Surgery, Drug Toxicity, Anesthesia
- Trial name
- NCT03882541
- Testing
- Music therapy, Sedation with midazolam
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Anoia
Neoplasms, Medication Toxicity
Study of Orally-Administered AMXT 1501 Dicaprate in Normal Healthy Volunteers
This is a Phase 1 study, which will assess the safety, PK, and pharmacodynamics (PD) of orally-administered AMXT 1501 dicaprate in normal healthy male volunteers.
- Conditions
- Neoplasms, Medication Toxicity, Tolerance
- Trial name
- NCT03077477
- Testing
- AMXT 1501
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aminex Therapeutics, Inc.
Benign Nontoxic and Toxic Goiter, Graves' Disease
rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter
The trials in this protocol deals with the effect of pretreatment with rhTSH on radioiodine treatment of thyroid size and function, in patients with nontoxic and toxic nodular goiter.
- Trial name
- NCT00145366
- Testing
- Recombinant human thyrotropin (Thyrogen)
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Toxicity;Chemical
Study of Single Oral Doses of HOPO 14-1 Evaluating Safety, Tolerability, Pharmacokinetics
The study objectives are to define the safety and tolerability profile of oral, single ascending dose (SAD) levels of HOPO 14-1 capsules in cohorts of healthy participants and to assess the pharmacokinetic (PK) and excretion…
- Trial name
- NCT05628961
- Testing
- HOPO 14-1
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- SRI International
Corneal Toxicity, Ototoxicity
A Comparison of Infection Rates Between Two Surgical Sites
Does the use of chlorhexidine scrub prior to cutaneous surgery on the face increase the chances of toxicity to the eyes or ears? In addition, does the us eof chlorhexidine scrub on the face prior to cutaneous surgery decrease the…
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Trial name
- NCT01263262
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol Drinking, Cigarette Smoking Toxicity
Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder
The proposed research will investigate whether smokers with vs. without current at-risk alcohol drinking (ARD) respond to reduced nicotine cigarettes by increasing their alcohol consumption or smoke exposure, thereby diminishing…
- Trial name
- RedNic (NCT02990455)
- Testing
- Reduced nicotine cigarettes
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Polycystic Ovary Syndrome
Endocrine Disruptors, Toxic and Essential Chemical Elements and Polycystic Ovary Syndrome
Studies have shown that endocrine disruptors (EDs) and toxic and essential chemical elements affect women's reproductive health and may play a role in the development of polycystic ovary syndrome (PCOS).
- Trial name
- NCT06968455
- Testing
- parabens
- Where
- Slovenia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Death, Sudden, Cardiac, Arrythmia
Monitoring of Arrhythmias in Patients Treated With Antipsychotics
Antipsychotics may be associated to life-threatening arrhythmias and sudden cardiac death. This is the fist study to estimated the arrhythmic burden using long-term monitoring by implantable loop recorder in patients treated with…
- Conditions
- Death, Sudden, Cardiac, Arrythmia, Antipsychotics and Neuroleptics Toxicity
- Trial name
- MAPP (NCT04575103)
- Testing
- Antipsychotic
- Where
- 18 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Cancer
Tumor Control, Treatment Toxicity, Quality of Life and Bio-Imaging Repository Databank (TQ-BIRD) for Cancer Patients
Our central hypothesis is that patient response to treatment, evaluated by full spectrum of outcome measures including tumor control, survival, toxicity, and quality of life (QoL), will correlate with biomarker expressions, which…
- Trial name
- TQ-BIRD (NCT05061342)
- Testing
- No experimental interventions 1. Observation; 2. Anticancer treatments, including surgery, systemic therapy, radiotherapy, Chinese traditional medicine, or palliative/supportive care.
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Fengming Kong