Clinical trials: Tracheal Extubation
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Postoperative Respiratory Complications
The Clinical Value of Applying TOF and TcPO2 to Guide Elderly Patients Extubation
Three hundred aged(age>65y) patients were randomized to Commom group(C group). Qualitative TOF monitoring (TOF group). Qualitative TOF and transcutaneous partial pressure of carbon dioxide monitoring(Unite group).
- Trial name
- NCT02327910
- Testing
- TOF unit TcPCO2 group, TOF group
- Volunteers
- 300 people
- Sponsor
- Beijing Municipal Science & Technology Commission
Delayed Emergence From Anesthesia
Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
Bispectral monitoring anesthesia with remifentanil-desflurane has a better post-operative recovery than remifentanil-propofol.
- Trial name
- NCT02631525
- Testing
- Desflurane, Propofol
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Cerebral Arterial Disease, Cerebral Aneurysm
Esmolol Infusion in Patients Undergoing Craniotomy
Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative…
- Trial name
- NCT02455440
- Testing
- Esmolol, Propofol and sevoflurane
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Acute Respiratory Distress
Physiologic Effects of Noninvasive Neurally Adjusted Ventilatory Assist (NAVA) Versus Noninvasive Pressure Support Ventilation in Patients at Risk for Respiratory Distress Needed Preventive Used of Noninvasive Ventilation After Extubation.
The purpose of this study is to compare inspiratory effort, comfort, gas exchange and patient ventilator synchrony during non-invasive neurally adjusted ventilatory assist or pneumatically triggered and cycled-off noninvasive…
- Trial name
- NAVA-VNI (NCT01928238)
- Testing
- Noninvasive neurally adjusted ventilatory assist (NIV-NAVA)., Noninvasive pressure support ventilation (NPSV)
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Bordeaux
Incomplete Reversal of Neuromuscular Block
Quality of Recovery After Reversal With Neostigmine or Sugammadex.
This study will compare patient recovery measures after reversal of neuromuscular blockade with neostigmine or sugammadex after surgery.
- Trial name
- NCT02909439
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Infant,Premature, Respiratory Failure
Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants
Very low birth weight infants are at increased risk of requiring prolonged duration of mechanical ventilation and multiple intubations, both of which are risk factors for ventilator-induced lung injury and BPD.
- Conditions
- Infant,Premature, Respiratory Failure, Respiratory Insufficiency, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT03558737
- Testing
- Nasal high-frequency jet ventilation (nHFJV), Nasal intermittent positive pressure ventilation (NIPPV)
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Respiratory Failure
The Efficacy of the Whisperflow CPAP System Versus Nasal High Flow in Patients at High Risk for Postextubation Failure
The purpose of this study is to compare the effect of continuous positive airway pressure (CPAP) delivered by the variable generator WhisperFlow System with high flow nasal cannula oxygen therapy in mechanically ventilated…
- Trial name
- NCT02918786
- Testing
- Nasal high-flow, CPAP
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Ramathibodi Hospital
Weaning Failure, Acute Respiratory Failure
Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
The purpose of this study is to determine whether, as compared with the Venturi mask, a nasal, high-flow oxygenation device (Optiflow) may reduce the extubation failure rate in patients needing oxygen therapy after extubation.
- Trial name
- RINO (NCT02107183)
- Testing
- Optiflow (Fisher & Paykel Healthcare), Venturi mask
- Where
- 14 sites in France, Greece and 2 more
- Volunteers
- 500 people
- Sponsor
- Catholic University of the Sacred Heart
Airway Extubation
Diaphragmatic and Pulmonary US for Extubation Success Prediction
The primary objective is to assess whether the fraction of diaphragmatic shortening in combination with the presence / absence of alveolar-interstitial syndrome evaluated through chest ultrasound may predict successful extubation…
- Trial name
- NCT02799056
- Testing
- Thoracic ultrasound
- Where
- Mexico
- Volunteers
- 82 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Extubation
Weaning And Variability Evaluation (WAVE)
The purpose of this study is to determine if variability in heart and breathing rates can be used to predict successful weaning.
- Trial name
- WAVE (NCT01086995)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Emergence Delirium
Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.
An optimum recovery profile after AT includes a rapid, smooth awakening without emergence agitation (EA), stable vital signs and oxygenation, reduced postoperative nausea and vomiting (PONV), controlled postoperative pain, and…
- Trial name
- NCT06010927
- Testing
- ketamine/midazolam, Ketofol
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Cardiovascular Diseases
Dysphagia in Cardiac Surgical Patients_
The proposed study seeks to determine the incidence of dysphagia and vocal fold mobility impairment (VFMI) in individuals undergoing cardiovascular surgical procedures.
- Trial name
- NCT04496986
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Voluntary Cough Peak Expiratory Flow (PEF) Testing
- Sponsor
- University of Florida
Extubation in Intensive Care Unit
EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit
Extubation in intensive care unit is a risky situation. Its failure is associated with an increase in the duration of mechanical ventilation and high morbidity and mortality.
- Trial name
- EXSUPEEP (NCT05147636)
- Testing
- Extubation with PEEP, Endotracheal Aspiration
- Where
- 11 sites in France
- Volunteers
- 425 people
- Sponsor
- Centre Hospitalier de Bourg en Bresse
Assess the Prediction of Successful SBT and Extubation of Trachea by Bedside Lung Ultrasound in Mechanically Ventilated Patients
Prediction of Weaning Outcome From Mechanical Ventilation Using Ultrasound
Examine the predictive value of lung ultrasound in assessing the success of SBTs and tracheal extubation among patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT06685224
- Testing
- Ultrasound Assessment of the aeration of lung tissue and Parasternal Intercostal Muscle Thickness
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Coronary Artery Bypass Graft and/or Aortic Valve Replacement Surgery
Sugammadex and Decreased Time to Extubation
The purpose of this study is to demonstrate faster time to extubation after arrival in the cardiothoracic intensive care unit (ICU) in patients undergoing isolated coronary artery bypass grafting (CABG), AVR and AVR/CABG…
- Trial name
- NCT03196167
- Testing
- Sugammadex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Emergence From Anesthesia
Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries
Although total intravenous anesthesia (TIVA) provides advantages such as accelerated recuperation and diminished postoperative nausea, it also has constraints, such as the potential for hemodynamic instability and inadequate…
- Trial name
- NCT07443163
- Testing
- Dexmedetomidine (Precedex®), magnesium sulfate
- Volunteers
- 40 people
- Sponsor
- Cairo University
Hypoxemic Respiratory Failure
Flow Rates of High-flow Nasal Cannula and Extubation Outcome
This is a single-center, open-label, randomized controlled trial to evaluate the effect of high-flow nasal cannula with a flow rate of 60 L/min versus 40 L/min after planned extubationon on a composite outcome of reintubation and…
- Trial name
- NCT04934163
- Testing
- Flow rate setting of high-flow nasal cannula (initially 60L/min), Flow rate setting of high-flow nasal cannula (initially 40L/min)
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Bypass
Oropharyngeal Humidification After Extubation on Thirst
In patients who have undergone endotracheal intubation following cardiac surgery, symptoms such as thirst, dysphagia (difficulty swallowing), restlessness, nausea, and vomiting are frequently observed, and these conditions…
- Trial name
- NCT07397221
- Testing
- Oropharyngeal Humidification with Water Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Muş Alparslan University
Weaning Failure, Mechanical Ventilation
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in Mechanically Ventilated ICU Patients
- Conditions
- Weaning Failure, Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Failure
- Trial name
- BIOMEXIC (NCT05637099)
- Where
- Netherlands
- Volunteers
- 181 people
- Sponsor
- Henrik Endeman