Clinical trials: Tractography
Neurological Diseases
In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III
White matter tracts connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses.
- Trial name
- FIBRATLAS (NCT02455284)
- Testing
- MRI
- Where
- 7 sites in France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Brain Tumor, Brain Pathology
Can we Use Resting-state fMRI and CSD Fiber Tractography for Presurgical Mapping?
This prospective study aims to investigate and validate the use of resting-state functional MRI (rs-fMRI) and high angular resolution diffusion imaging (HARDI), specifically constrained spherical deconvolution (CSD) tractography…
- Conditions
- Brain Tumor, Brain Pathology, Epilepsy, Vascular Malformations, Brain
- Trial name
- NCT06040580
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteer
Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas
Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord.
- Trial name
- TRACTOCORD (NCT05079945)
- Testing
- Spinal cord Tractography in order to differentiate spinal tracts.
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Parkinson's Disease, Apathy
Role of Mesocorticolimbic Pathway in Apathy of Patients With Parkinson's Disease. - Study Using Diffusion Tensor Imaging and Fibres Tracking
Use lay language. Apathy is one of the most under recognised, underdiagnosed and poorly managed aspects of Parkinson's disease. Depending on methodological approach of the study, its prevalence is estimated to be between 16 and…
- Trial name
- NCT01794195
- Testing
- Diffusion tensor imaging and fibres tracking
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson's Disease, Impulse Control Disorders
Exploration of Mesocorticolimbic Pathway in Impulse Control Disorders in Parkinson's Disease: Study Using Tensor Diffusion Imaging and Tractography.
Impulse control disorders (ICD) are frequent in Parkinson's Disease. Neurobiological substrates of these symptoms are largely unknown.
- Trial name
- TCI-IRMdiff (NCT02796040)
- Testing
- MRI
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Volunteers
Assessment of Magnetic Resonance Imaging Neurography and Tractography for Preoperative Mapping of Pelvic Nerves
This project aims at assessing two MRI acquisition methods, neurography and tractography, for the visualization of pelvic nerves.
- Trial name
- Neuro-Tracto (NCT02582346)
- Testing
- MRI acquisition - no contrast agent
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IHU Strasbourg
Stroke
Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies
To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute…
- Trial name
- NCT00407628
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Improving Accuracy of Implanting Stimulation Electrodes
Correlation of Tractography and Motor Evoked Potentials in Deep Brain Stimulation
The goal is to establish another anatomical referencing system in order to achieve an even higher accuracy when implanting stimulation electrodes.
- Trial name
- NCT03136302
- Testing
- Deep Brain Stimulation
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Traumatic Brain Injury
Traumatic Brain Injury Biological Diagnosis Via High Definition Tractography Asymmetry Screening
The primary purpose of this study is to validate the High Definition Fiber Tracking (HDFT/HDFTAS) technology, so that faster, more reliable diagnosis can be implemented in Traumatic Brain Injury (TBI).
- Trial name
- NCT02728960
- Testing
- MRI of the Brain (No Contrast) Scan
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Infant Development
Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques.
- Trial name
- NCT02058225
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital