Clinical trials: Tranexamic Acid, open to volunteers
Epistaxis Nosebleed
Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called…
- Trial name
- Bloody SIMPLE (NCT06997796)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Dr. Anne Conlin
Abortion, Dilation and Evacuation
Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use
- Trial name
- NCT06820177
- Testing
- Tranexamic Acid
- Where
- 3 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hemoptysis
Comparison Between Efficacy of Inhaled VS Intravenous Tranexamic Acid for Hemoptysis
This will be a prospective comparative cohort study and will take place at the Ward II- Ojha Institute of Chest Diseases (OICD) ,Dow University of Health Sciences in Karachi.
- Trial name
- NCT07845747
- Testing
- Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 154 people
- Sponsor
- Dow University of Health Sciences
Trauma Coagulopathy
Tranexamic Acid in Patients With Traumatic Bleeding Based on Dynamic Monitoring of Thromboelastography
Trauma is an important global public health problem and is the leading cause of death in people under 40 years old. Studies have shown that early prehospital administration of TXA 1 g intravenously followed by a continuous…
- Trial name
- NCT06736860
- Testing
- Tranexamic acid (TXA) injection
- Where
- China
- Volunteers
- 580 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Orbital Edema, Orbital Ecchymosis
The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery
Tranexamic acid (TXA) is a synthetic reversible competitive inhibitor to plasminogen lysine receptor, which prevents plasmin formation and stabilizes the fibrin matrix, thus reducing bleeding.
- Trial name
- NCT06450392
- Testing
- Tranexamic acid injection, Tranexamic Acid in NaCl,Iso-Os 1,000 Mg/100 mL (10 Mg/mL) INTRAVEN INTRAVENOUS SOLUTION, PIGGYBACK (ML), normal saline - injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Montefiore Medical Center
Rotator Cuff Tear Repair
Evaluation of the Therapeutic Effect of Local Application of Tranexamic Acid in Rotator Cuff Repair
This prospective randomized controlled trial aims to evaluate the efficacy and safety of intraosseous tranexamic acid administration during arthroscopic rotator cuff repair.
- Trial name
- NCT07714473
- Testing
- Tranexamic Acid, Normal Saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hua Luo
Anaemia
Tranexamic Acid for Anaemia Trial
Anaemia is when the body does not have enough healthy red blood cells to carry oxygen. It is common in women because they lose blood every month during their periods.
- Trial name
- WOMAN-3 (NCT06519422)
- Testing
- Tranexamic Acid 500 MG
- Where
- 3 sites in Nigeria, Pakistan and 1 more
- Volunteers
- 4,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Shoulder Arthroplasty
Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty
The purpose of this clinical trial is to evaluate the short-term clinical outcomes of patients undergoing total shoulder arthroplasty who receive an extended postoperative course of oral tranexamic acid
- Trial name
- NCT06902714
- Testing
- oral tranexamic acid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Brain Tumor, Bleeding
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
The goal of this clinical trial is to test the effect of a drug called tranexamic acid (TXA) on reducing blood loss in participants undergoing surgery to remove brain tumors. The main questions it aims to answer are: 1.
- Trial name
- NCT06229483
- Testing
- TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Stephen Lownie
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital
Colon Neoplasm
Tranexamic Acid During Colonic Endoscopic Resection Procedures
Colonoscopy with polypectomy reduces the incidence and mortality associated with colon cancer. However, polypectomy is associated with adverse events such as bleeding.
- Trial name
- NCT05345613
- Testing
- Tranexamic acid, Standard
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Bleeding After GI Endoscopy
Endoscopic Application of Hemostatic Drug Powder in Lower Gastrointestinal Bleeding: A Pilot Study
This clinical trial will enroll patients at National Cheng Kung University Hospital. All patients who are hospitalized for lower gastrointestinal bleeding and undergo colonoscopy will be invited to participate.
- Trial name
- NCT07679139
- Testing
- Tranexamic acid and sucralfate powder spray, Standard endsocopic hemostasis
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Blood Loss, Surgical
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS.
- Trial name
- NCT06725732
- Testing
- Tranexamic Acid (TXA), Tranexamic Acid
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Blood Coagulation Disorder, Postoperative Blood Loss
Comparative Study of Tranexamic Acid Dosing in Cardiac Surgery
Tranexamic axid is routinely used as an antifibrinolytic agent in cardiac surgery to reduce the risk of blood loss and transfusion.
- Conditions
- Blood Coagulation Disorder, Postoperative Blood Loss, Adverse Drug Event, Fibrinolysis; Hemorrhage
- Trial name
- NCT07164300
- Testing
- Tranexamic acid at a dose of 10 mg/kg followed by 1 mg/kg/h, Tranexamic acid at a dose of 20 mg/kg, Tranexamic acid at a dose of 30 mg/kg
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Ioannina
Intracerebral Hemorrhagic Stroke
Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage
This multicenter, pragmatic randomized, open-label clinical trial aims to assess whether Tranexamic Acid improves outcomes in adult patients with spontaneous intracerebral haemorrhage.
- Trial name
- NCT05836831
- Testing
- Tranexamic acid injection
- Where
- 48 sites in India
- Volunteers
- 3,400 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Menorrhagia, Abnormal Uterine Bleeding
Efficacy of Calcium Dobesilate Versus Tranexamic Acid for Treating Heavy Menstrual Bleeding
The goal of this clinical trial is to determine if calcium dobesilate is an effective alternative to tranexamic acid for treating menorrhagia in women aged 18 to 39 years.
- Trial name
- NCT06763094
- Testing
- Calcium dobesilate (Doxium), Tranexamic Acid
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
Chronic Kidney Diseases, Acute Kidney Injury
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
The BRACKETS pilot study is a multicentre, prospective, randomized controlled trial of prophylactic preoperative tranexamic acid (TXA) versus placebo and, using a partial factorial design, of prophylactic preoperative…
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Bleeding, Surgery
- Trial name
- BRACKETS (NCT06337838)
- Testing
- Desmopressin Injectable Solution, Tranexamic Acid Injectable Product
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Antifibrinolytic Agents
Point-of-care Measurement of the Antifibrinolytic Activity of Tranexamic Acid in Cardiac Surgery
Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can reduce postoperative blood loss and packed red blood cell transfusions during cardiac surgery.
- Trial name
- PAATICS (NCT06128330)
- Testing
- Tranexamic acid bolus 20 mg/kg, Tranexamic acid bolus 10 mg/kg, Tranexamic acid bolus 1 mg/kg
- Where
- Switzerland
- Volunteers
- 322 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Spinal Deformity, Degenerative Lumbar Spinal Stenosis
Tranexamic Acid in Adult Spinal Deformity Surgery
Posterior spinal surgery for adult deformity is associated with high incidence of blood loss and need for blood transfusion and intraoperative blood salvage, with associated increased cost and risk for perioperative…
- Conditions
- Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical
- Trial name
- NCT03553186
- Testing
- Tranexamic Acid 100 MG/ML
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York