Clinical trials: Trans-epidermal Water Loss
Atopic Dermatitis (AD), Cholesterol
A Study on the Efficacy of 2% Cholesterol Cream in Atopic Dermatitis
Atopic dermatitis is a common chronic inflammatory skin condition characterized by impaired skin barrier function, leading to increased transepidermal water loss (TEWL), dry skin, and itching.
- Conditions
- Atopic Dermatitis (AD), Cholesterol, Skin Barrier to Water Loss, Skin Allergy
- Trial name
- NCT07503197
- Testing
- Topical 2% cholesterol cream
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Institute of Dermatology, Thailand
Plaque Type Psorisis, Non-pustular Palmoplantar Psoriasis
Clinical Study on the Medical Devices PROXERA PSOMED 20 and PROXERA PSOMED 40 for the Treatment of Plaque Psoriasis and Non-pustular Palmoplantar Psoriasis
This single-center interventional study was designed to evaluate the efficacy and safety of two CE-marked topical medical devices: PROXERA PSOMED 20 is being studied in participants with non-palmoplantar plaque psoriasis, while…
- Trial name
- PASI (NCT07545902)
- Testing
- PROXERA PSOMED 20 cream; PROXERA PSOMED 40 gel
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- ICIM International S.r.l.
Dry and Sensitive Skin
Validation of Skin Instrumentation to Detect Ceramide-Driven Lipid Replenishment - Assessing Skin Glow, Hydration, Trans Epidermal Water Loss, Skin Surface Assessment, Sebum and Least-Reflection Factor.
This is a single-center, open-label, split-face, site-randomized validation study, NB250045-NB-V designed to establish and confirm the reliability, reproducibility, and sensitivity of various skin measurement methods.
- Trial name
- NCT07423325
- Testing
- Marketed Product - CeraVe Moisturizer
- Where
- India
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Diabetes, Diabetic Foot
TEWL Biomarker Study for Diabetic Foot Ulcer Recurrence
This is a multicenter study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict DFU wound recurrence.
- Conditions
- Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
- Trial name
- TEWL (NCT04558775)
- Testing
- Observational
- Where
- 6 sites in United States
- Volunteers
- 418 people
- Sponsor
- University of Michigan
Diabetic Foot, Ulcer Foot
Diabetic Foot Ulcer Recurrence: Pilot Study
In this prospective pilot study, patients with DFU visiting the Indiana University Comprehensive Wound Center will be enrolled. Patients enrolled in the study will be followed for 16 weeks for wound closure(Phase A), and will…
- Trial name
- DFUCO (NCT03479242)
- Testing
- no interventions
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Trans-epidermal Water Loss
Study to Investigate the Effect of Superba Boost on the Skin
Study to determine the effect of 12 weeks daily consumption of Superba Boost as compared to placebo on reduction in Trans-Epidermal Water-Loss (TEWL).
- Trial name
- NCT05711303
- Testing
- Superba Boost
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Trans Epidermal Water Loss
Effect of Twice Daily Application of Coconut Oil in Reducing Water Loss From Skin of Premature Babies in First Week of Life
The skin of newborn infants is immature and ineffective as a barrier. Preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness.
- Trial name
- TEWL (NCT01758068)
- Testing
- Coconut Oil Application
- Volunteers
- 74 people
- Sponsor
- Lady Hardinge Medical College
Dermis Density, Wrinkles
The Effect of 12-week Dietary Intake of Food Supplements Containing Collagen on Dermis Density and Other Skin Parameters
The aim of the randomized, double-blind, placebo-controlled, one-period effectiveness study is to compare the effects of multiple-dose 12 weeks daily dietary supplementation with 10 g collagen alone or 5 g or 10 g of collagen in…
- Conditions
- Dermis Density, Wrinkles, Skin Hydration, Trans Epidermal Water Loss (TEWL)
- Trial name
- TO-COSKIN (NCT04988412)
- Testing
- Investigational product 1, Investigational product 2, Investigational product 3
- Where
- Slovenia
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Atopic Dermatitis, Skin Condition
Clinical Study of Partially Hydrolysed Protein Infant Formula on Trans-epidermal Water Loss (TEWL)
This is a single-centre, prospective, randomized, open-label, controlled trial of 200 infants 42±7 days of age. Subjects will be randomized to one of two open label feeding intervention group: Intact Cow's Milk Protein Formula…
- Trial name
- NCT04763512
- Testing
- Intact Cow's Milk Protein Formula, Partially Hydrolysed Whey Formula
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Chronic Wounds, Biofilm Infection
Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence
This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function.
- Conditions
- Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL), Diabetic Foot
- Trial name
- DFUBiofilm (NCT05172089)
- Where
- 2 sites in United States
- Volunteers
- 405 people
- Sponsor
- University of Pittsburgh
Trans Epidermal Water Loss (TEWL)
Effect of Coconut Oil Application in Reducing Water Loss From Skin of Premature Babies in First Week of Life (TEWL)
The skin of newborn infants is immature and ineffective as a barrier. Preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness.
- Trial name
- TopOilTewl (NCT01364948)
- Testing
- Coconut oil application, No oil application
- Where
- India
- Volunteers
- 74 people
- Sponsor
- All India Institute of Medical Sciences
Skin Sensitivity, Trans-epidermal Water Loss
Two Supplemented Against Skin Reactivity
In recent decades, the incidence of subjects presenting reactive skin has considerably increased in industrialized countries. Probiotics are live microorganisms which, when ingested in sufficient amounts, have beneficial effects…
- Conditions
- Skin Sensitivity, Trans-epidermal Water Loss, Clinical Score, Assessment of Skin Moisturization Factors
- Trial name
- NCT01368224
- Testing
- Lactobacillus paracasei NCC 2461 and Bifidobacterium longum NCC3001
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Dermis Density, Trans Epidermal Water Loss (TEWL)
The Effect of 12-week Dietary Intake of Syrup Containing CoQ10 and Collagen on Dermis Density and Other Skin Parameters
Placebo controlled double-blind multi-dose comparative study of the effects of coenzyme Q10 and collagen formulation with improved water-solubility in healthy adults.
- Conditions
- Dermis Density, Trans Epidermal Water Loss (TEWL), Skin Hydration, Wrinkles
- Trial name
- Q10-collagen (NCT03811756)
- Testing
- Test syrup containing CoQ10 and collagen
- Where
- Slovenia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences