Clinical trials: Transcranial Electrical Stimulation (tES)
Insomnia
Wearable Transcranial Electrical Stimulation (tES) for Insomnia
The purpose of this study is to investigate the ability of a translational device, Teledyne PeakSleep, to reduce sleep onset latency, reduce time awake after sleep onset and improve restfulness and the subjective benefits of…
- Trial name
- NCT06100185
- Testing
- PeakSleep
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Uniformed Services University of the Health Sciences
Substance Use Disorders
Enhancing Addiction Treatment Through Psychoeducation
Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making.
- Trial name
- NCT07178158
- Testing
- Installing the Metacognium software app, Continue treatment as usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Sleep Disturbance, Insomnia
Closed Loop TES for Enhancing Slow Wave Sleep
Compare closed-loop with open-loop application of TES to enhance slow waves of sleep.
- Trial name
- NCT03751982
- Testing
- Transcranial Electrical Neuromodulation (TES)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brain Electrophysiology Laboratory Company
Primary Cervical Dystonia
Transcranial Electrical Stimulation for Cervical Dystonia
There are two phases. Phase I: A single visit which includes a screening, clinical scales, and a MRI scan with simultaneous tES/sham tES in a randomized block design.
- Trial name
- NCT03369613
- Testing
- transcranial electrical stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Volunteers
Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques
Background: Little is known about the time it takes for nerve signals to go from one area of the brain to another. Using advanced methods for brain research, researchers want to look at the time it takes to send messages between…
- Trial name
- NCT03223636
- Testing
- TMS, MRI
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression - Major Depressive Disorder
Dual Neuromodulation for Depression: Boosting TMS With tES
Major depressive disorder (MDD) is a common and disabling condition. Transcranial magnetic stimulation (TMS) is an established non-invasive neuromodulation treatment for depression, but clinical response varies considerably…
- Trial name
- DUAL MOD (NCT07879924)
- Testing
- Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Mersey Care NHS Trust
Attention Deficit Disorder With Hyperactivity, Neurodevelopmental Disorders
tES Modalities for the Treatment of ADHD
This project investigates the efficacy of transcranial electrical stimulation (tES) modalities, specifically transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), for treating…
- Trial name
- NCT06974136
- Testing
- transcranial electrical stimulation
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Performance Enhancing Product Use, Sleep
Optimizing Volunteer Comfort for Transcranial Electrical Stimulation (TES): An Assessment
Transcranial electrical stimulation (TES) utilizing weak electrical fields (<5 milliamps of current - as proposed in the present pilot study) is an extremely safe therapeutic technique in use for over 40 years.
- Trial name
- TES (NCT04474015)
- Testing
- transcranial electric stimulation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Depression, Depressive Disorder, Treatment-Resistant
Improving Brain Stimulation Through Imaging
There are two protocols, one involving rTMS therapy in people with treatment resistant depression and one involving tDCS in people with stress from the COVID 19 pandemic.
- Conditions
- Depression, Depressive Disorder, Treatment-Resistant, COVID Stress, PTSD - Post Traumatic Stress Disorder
- Trial name
- IBSI (NCT03851380)
- Testing
- Psychological / Functional Assessment, Structural and Functional MRI, Transcranial Magnetic Brain Stimulation and MR Image Guidance
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Language Development, Learning
Brain Stimulation Paired With Structured Language Learning in Adults
This study investigates whether transcranial electrical stimulation (tES) delivered during structured language-learning sessions affects the rate and quality of second-language acquisition in adults.
- Trial name
- NCT07762118
- Testing
- Active transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- General Neuro Inc.
Depression
fMRI Study of tES in Major Depression
This is a functional MRI study that will examine the effects of noninvasive transcranial electrical stimulation (tES) on brain function in individuals with Major Depression.
- Trial name
- NCT04031547
- Testing
- Transcranial Electrical Stimulation (tES)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northwestern University
Ischemic Stroke, Hemorrhagic Stroke
Effects of Transcranial Electrical Stimulation in Stroke Individuals
The present study will use transcranial electrical stimulation (tES) with conventional physical therapy in sub-acute (at least 2 weeks after stroke onset) to chronic stroke within 2 years to investigate the effect on cortical…
- Conditions
- Ischemic Stroke, Hemorrhagic Stroke, Chronic Stroke, Subacute Stroke
- Trial name
- NCT06134921
- Testing
- transcranial direct current stimulation (Active), transcranial alternating current stimulation (active), Conventional physical therapy program
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
PARKINSON DISEASE (Disorder)
Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms
This study tests a new, non-invasive brain stimulation device called Sphere V3.0 to help improve movement problems in people with Parkinson's disease.
- Trial name
- NCT07182058
- Testing
- Transcranial Electrical Stimulation Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- U: The Mind Company
Transcranial Electric Stimulation
Mechanistic Validation of Human Multipolar TES-TI: Amplitude Modulation, Frequency, and Benchmarking
This study is to find out whether and how a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults.
- Trial name
- MINT (NCT07752745)
- Testing
- TES-TI with hdEEG
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
Digital Twins for Model-driven Non-invasive Electrical Brain Stimulation
The purpose of this study is to obtain preliminary data in advance of a larger clinical trial designed to test whether repeated, daily sessions of at-home transcranial alternating current stimulation (tACS) can lead to a…
- Trial name
- NEUROTWIN (NCT06826261)
- Testing
- transcranial alternating current stimulation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Sleep Deprivation, Mental Competency
Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep
The purpose of this study is to determine if the enhancement of electroencephalographic (EEG) slow-wave activity using transcranial electrical stimulation (TES) at Slow Oscillation (SO) frequency, during a restricted period of…
- Trial name
- NCT02945501
- Testing
- NeuroConn DC Stimulator PLUS
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Memory Impairment
The Effect of tES on a Cognitive Training
The aim of this study is to investigate the effect of a transcranial electrical stimulation (tES) on a cognitive training in healthy elderly and memory impaired participants.
- Trial name
- NCT03475446
- Testing
- real anodal tDCS healthy elderly, real tACS healthy elderly, real anodal tDCS MCI
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Bern
Trigeminal Neuralgia (TN)
Neurophysiologic Signatures of Trigeminal Neuralgia Pain
Trigeminal neuralgia (TN) is an idiopathic pain disorder that is characterized by episodic attacks of intense facial pain, described as paroxysms of stabbing, electric, or explosive pain, and lasting for a few seconds or longer…
- Trial name
- NCT03778177
- Testing
- transcranial electrical brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Florida