Clinical trials: Transcranial Ultrasound Stimulation
Intracerebral Hemorrhage, Hemiplegia
Feasibility Study of Transcranial Ultrasound Stimulation (TUS) on Stroke Patients
Currently, the main treatment method for Intracerebral Hemorrhage (ICH) is medication or surgery. However, the effectiveness of medicines is moderate and there are several side effects.
- Trial name
- NCT04877184
- Testing
- Transcranial ultrasound stimulation and rehabilitation, Rehabilitation
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Cheng-Hsin General Hospital
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cognitive Enhancement
Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working…
- Trial name
- NCT06829368
- Testing
- Transcranial Focused Ultrasound Stimulation
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Mild Neurocognitive Disorder, Healthy Aging
tFUS for Memory in mNCD and Healthy Adults
Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus…
- Trial name
- NCT06718140
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02723929
- Testing
- active low-intensity transcranial electrical stimulation/active transcranial ultrasound
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Spaulding Rehabilitation Hospital
Depressive Disorder, Major, Depression
Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
Depression is a leading cause of disability worldwide, affecting roughly 21 million adults. Repetitive Negative Thought (RNT) has been identified as a potential maintaining factor in depression, such that those who exhibit higher…
- Trial name
- DMNtFUS (NCT06320028)
- Testing
- Non-Invasive Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Tourette Syndrome
Transcranial Ultrasound Stimulation for Tourette Syndrome
This is a phase 1 clinical trial investigating the use of low-energy Transcranial Ultrasound Stimulation (TUS) to treat Tourette Syndrome (TS). Objectives and Background.
- Trial name
- TUS-TS (NCT07699783)
- Testing
- Focused ultrasound stimulation
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Sleep Disturbance, Stress, Psychological
Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement
This study evaluates a wearable system (NEUSleeP) that combines overnight EEG recording with transcranial focused ultrasound (tFUS) targeted to deep brain structures involved in REM sleep regulation (e.g., subthalamic nucleus).
- Conditions
- Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
- Trial name
- NEUSleeP (NCT07190287)
- Testing
- NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Chronic Pain, Osteoarthritis
Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with osteoarthritis of the knee.
- Trial name
- NCT01404052
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Spaulding Rehabilitation Hospital
Parkinson Disease (PD), Essential Tremor
Modulate Tremor Severity With Low-intensity Focused Ultrasound Stimulation Targeting the Deep Nucleus of Patients With Refractory Hand Tremor.
The study plans to recruit 12 patients with Parkinsonian tremor, essential tremor, or dystonic tremor. After receiving NaviFUS-ctbTUS stimulation, the improvement in their tremor will be recorded.
- Conditions
- Parkinson Disease (PD), Essential Tremor, Dystonic Tremor, Continuous Theta Burst Stimulation Transcranial Focused Ultrasound
- Trial name
- NCT07172295
- Testing
- Accelerated NaviFUS-ctbFUS stimulation
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Tinnitus, Sleep Disturbances
Low-intensity TUS for Sleep Disturbances in Patients With Chronic Tinnitus
Background: Tinnitus, as a common symptom, can jeopardize the sleep quality and brain function and even lead to hearing loss and cognitive decline in elderly patients.
- Conditions
- Tinnitus, Sleep Disturbances, Cognition
- Trial name
- NCT06776705
- Testing
- Low-intensity transcranial ultrasound stimulation
- Where
- 2 sites in Hong Kong
- Volunteers
- 14 people
- Sponsor
- Chinese University of Hong Kong
Cognitive Deficit in Schizophrenia
Efficacy and Mechanisms of TUS on Cognitive Deficits in Schizophrenia: Based on the Hippocampal-Prefrontal Circuit
Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome. Prior studies indicated that abnormalities in the hippocampus-prefrontal circuit and glutamate/GABA imbalances may lead to cognitive…
- Trial name
- NCT06904092
- Testing
- Transcranial ultrasound stimulation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Mental Health Center
Healthy Participants
Cerebellar Functions in Visuomotor Adaptation
Transcranial focused ultrasound stimulation (tFUS) will be used in this study to functions of the cerebellum in human motor learning. Participants will complete a visuomotor task while receiving stimulation pulses from tFUS.
- Trial name
- NCT04168086
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcohol Use Disorder (AUD), Transcranial Ultrasound Stimulation
Transcranial Ultrasound Stimulation as a Neuromodulation Therapy for Craving and Relapse Behaviors in Alcohol Use Disorder.
This study aims to evaluate the efficacy of transcranial ultrasound stimulation in reducing cravings and preventing relapse in individuals with alcohol use disorders.
- Trial name
- NCT06867224
- Testing
- Active TUS-vmPFC
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Mental Health Center
COVID-19, Brain Fog
Transcranial Ultrasound Stimulation for Cognitive Function Modulation in Patients With Post COVID-19 Brain Fog
This study aims to investigate whether a specific brain region mediates the cognitive deficit in long COVID brain fog, and whether targeted modulation of this region can improve cognition.
- Conditions
- COVID-19, Brain Fog, Long COVID, Transcranial Ultrasound Stimulation
- Trial name
- NCT07154199
- Testing
- real transcranial ultrasound stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Schizo Affective Disorder
Exploring the Feasibility of Transcranial Ultrasound Stimulation in the Treatment of Schizophrenia
1. The purpose of this study is to evaluate the safety and feasibility of transcranial ultrasound stimulation (TUS) treatment in patients with schizophrenia.
- Trial name
- NCT07621549
- Testing
- Transcranial Ultrasound Stimulation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far Eastern Memorial Hospital
Parkinson's Disease
Non-invasive Neurostimulation in Parkinson's Disease
In this study, the investigators aim to investigate the effects of non-invasive neurostimulation - low-intensity transcranial electrical stimulation in conjunction with transcranial ultrasound (TUS)- on the motor symptoms…
- Trial name
- NCT01615718
- Testing
- low-intensity transcranial electrical stimulation, transcranial ultrasound
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Spaulding Rehabilitation Hospital
Healthy Participants
Ultrasound Effects on Human Motor Cortical Plasticity
The purpose of this study is to test the duration and effect of single element focused ultrasound to the primary motor cortex on healthy human participants with the use of transcranial focused ultrasound and transcranial magnetic…
- Trial name
- NCT04168762
- Testing
- Transcranial Ultrasound Magnetic Stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alzheimer Disease
Feasibility Study of Transcranial Ultrasound Stimulation on Alzheimer's Disease Patients
Currently, the main treatment method for Alzheimer's disease (AD) is chemotherapy. However, the effectiveness of drugs is moderate and there are several side effects.
- Trial name
- TUS (NCT03896698)
- Testing
- Transcranial Ultrasound Stimulation
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Yang Ming Chiao Tung University
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
- Trial name
- LIFUP-MCIAD (NCT05417555)
- Testing
- Low-Intensity Focused Ultrasound Pulsation (LIFUP)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles