Clinical trials: Transcriptome
Corona Virus Infection
Differential Expression of Cytokines, Transcriptome and miRNA in Coronavirus Disease 2019 (COVID-19) Egyptian's Patients
The aim of this effort is to study host-pathogen interaction in Egyptian patients infected with COVID-19. The investigators will perform genome-wide miRNA and transcriptome screens in the infected patients along with healthy ones…
- Trial name
- NCT04583566
- Testing
- COVID-19 Diagnostic and Assessment Tests
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Tuberculosis
Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries
The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves.
- Trial name
- ERASE-TB (NCT04781257)
- Testing
- New test candidates
- Where
- 3 sites in Mozambique, Tanzania and 1 more
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
Immune System Diseases, Infections
Epigenetic Memory of Vitamin D Supplementation
The investigators will study the mechanistic details of dietary programming of the epigenome at the example of epigenetic programming of primary human immune cells with the micronutrient vitamin D3.
- Conditions
- Immune System Diseases, Infections, Healthy Lifestyle
- Trial name
- VitDPAS (NCT06104111)
- Testing
- Vitamin D3
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Atopic Dermatitis (AD), Non-atopic Healthy Controls
Atopic Dermatitis (AD) and Food Allergy
This is a prospective, single center, clinical mechanistic pilot clinical research study. Participants will not receive any investigational agent.
- Trial name
- NCT03168113
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Thyroid Cancer
Observational Study Analysing the Transcriptome and Mutational Status of Thyroid Carcinomas of Follicular Origin with Different Degrees of Malignancy
Thyroid cancer (TC) is the most common endocrine malignancy, with well-differentiated thyroid carcinomas (DTCs)-papillary (PTC) and follicular (FTC)-comprising the majority of cases.
- Trial name
- TRAMT (NCT06878534)
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Gene Expression, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA
Febrile illness is a common condition, particularly among young patients and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Gene Expression, Gene Expression Profiling, Infection, Viral Diseases
- Trial name
- NCT06838780
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Prediabetes / Type 2 Diabetes, Obesity and Overweight
An Integrative Study of the Role of Microbiome, Metabolome, Transcriptome and Chronobiology in the Context of Type 2 Diabetes.
The goal of this descriptive clinical study is to investigate daily oscillations in glycaemic control between healthy adults and adults with excess weight and who have early-stage prediabetes or T2D and are not taking medications…
- Conditions
- Prediabetes / Type 2 Diabetes, Obesity and Overweight, Insulin Resistance
- Trial name
- KRONODIABET (NCT06783218)
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Asthma, Eosinophilic Asthma
Effect of Mepolizumab on Severe Eosinophilic Asthma
Two parts: A:Case-control study including 15 healthy adult donors and 15 severe adult eosinophilic asthmatics selected for treatment with mepolizumab.
- Trial name
- EMESEA (NCT04641741)
- Testing
- Mepolizumab 100 MG
- Where
- 5 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinico Universitario de Santiago
Zinc Deficiency
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B)
The specific aim of this protocol is to examine differential expression of specific mRNAs and proteins that occur when the dietary intake of zinc is acutely reduced below the dietary requirement for a period of ten days.
- Trial name
- NCT01221129
- Testing
- Acclimation, Dietary zinc depletion, Dietary zinc repletion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Nutritional Intervention
Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal
The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.
- Trial name
- NCT01995110
- Testing
- high-fat meal A, high-fat meal B, high-fat meal C
- Where
- 2 sites in Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Agroscope Liebefeld-Posieux Research Station ALP
Autosomal-dominant Hyper-IgE Syndrome
Safety, Tolerability, and Immunogenicity of One Dose of NDV 3A Vaccine in People With STAT3-Mutated Hyper-IgE Syndrome
Background: AD-HIES is a disease that weakens the immune system. It puts people at risk for infections, particularly Staph and Candida infections.
- Trial name
- NCT02996448
- Testing
- NDV-3A
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Milk
Developing Remote Human Milk Collection as a Novel Technique for Transcriptome Sequencing
This study will develop a protocol for remote human milk collection for use in gene expression research through application of ribonucleic acid (RNA) preservation reagents.
- Trial name
- NCT07118852
- Testing
- Remote Human Milk Sample Collection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Atopic Dermatitis
Skin Tape Transcriptome Methods in Children
This pilot study will evaluate new methods for the collection, storage, shipment, and RNA extraction of skin tape specimens from children with atopic dermatitis (AD) that will facilitate the multi-center SunBeam Birth Cohort…
- Trial name
- NCT04180644
- Testing
- Skin tape strips
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Heart Transplant Rejection
Biomarkers for Diagnosis, Prognosis, and Targeted Therapy After Heart Transplantation
The objective of this prospective observational single center study is to investigate donor-derived cell-free DNA (ddcfDNA), peripheral blood platelet mRNA, peripheral blood extracellular vesicle mRNA, and peripheral blood…
- Trial name
- EMBIO (NCT06064123)
- Testing
- Cell-free DNA
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Healthy
Circulating Endothelial Compartment During Normal and Pathological Aging
This part of the project aims to describe changes in markers of vascular competence (Endothelial Microparticles Platelet (EMP), Circulating endothelial cells (CEC) and Circulating endothelial progenitors (EPC)) at different ages…
- Trial name
- VIMOPEIL (NCT01038700)
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autoimmune Gastritis
Clinical Characteristics, Lifestyle and Multi-omics Analysis in Autoimmune Gastritis
This research will be conducted nationwide in patients with autoimmune gastritis, focusing on their clinical characteristics, possible risk factors, and multi-omics analysis.
- Trial name
- NCT05820607
- Testing
- Microbiome, metabolome, transcriptome, genome
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Acute Febrile Illness
Clinical Study of Transcriptome-based Diagnostic Biomarker for Acute Febrile Illness
Acute febrile illness is the main cause of outpatient visits，and bacterial and viral infections remains the most common cause. The diagnosis of infection is still based on symptoms and traditional techniques, resulting in overuse…
- Trial name
- NCT06552975
- Testing
- Infection
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Asthma Patients
ICS+LABA Vs. ICS+LABA+Omalizumab: Impact on Asthma Control and Gene Expression
Asthma is a chronic respiratory disease characterized by airway inflammation and obstruction, leading to wheezing, breathlessness, chest tightness, and coughing.
- Trial name
- NCT06869382
- Testing
- Foster BDP/Formoterol, Omalizimab
- Where
- Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Obesity, Inflammation
Transcriptomics of Mononuclear Cells and Inflammatory Status of Obese Patients Treated With Omega-3 Fatty Acids
The main objective is to determine the effect that supplementation with 4.8 g/day of w-3 FA [3.2g eicosapentaenoic acid (EPA) and 1.6 g docosahexaenoic acid (DHA)] have on the inflammatory state of obese patients (BMI ≥ 35.0…
- Conditions
- Obesity, Inflammation, Immune System Disorder
- Trial name
- NCT05219890
- Testing
- Fish oil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Inhalant Use Disorder
Brain Imaging Studies of the Effect of Inhalant Use Disorder
Inhalants substance misuse is an important public health problem whose prevalence is approximately 1% in the general population and 7% among high school students in Mexico.
- Trial name
- NCT02188914
- Testing
- Positron emission tomography scan, Magnetic resonance imaging
- Where
- Mexico
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Miguel Ángel Mendoza Meléndez