Clinical trials: Transcutaneous Vagal Nerve Stimulation
Healthy
TaVNS Application Timing During Robotic Sensorimotor Task
The goal of this clinical trial is to evaluate the feasibility and effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in enhancing sensorimotor learning and adaptation.
- Trial name
- SMTaVNS2024 (NCT06294509)
- Testing
- in-house developed transcutaneous auricular Vagus Nerve Stimulation device
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Olivier Lambercy
Healthy Volunteers
Non-Invasive Transcutaneous Auricular Vagus Nerve Stimulation Applied at Different Durations in Healthy Adults
This randomized, participant-blinded, sham-controlled interventional study aims to compare the acute effects of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) applied at different durations on autonomic…
- Trial name
- taVNS-DUR (NCT07532005)
- Testing
- Active taVNS
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Sinop University
PTSD
Non-invasive Nerve Stimulation and Sleep
People often have difficulty sleeping. Reasons are many. But, difficulty falling and staying asleep are common issues. Sleep difficulties are common in disorders such as Post Traumatic Stress Disorder.
- Trial name
- NINS (NCT04021537)
- Testing
- non-invasive nerve stimulation
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
tVNS Effects on Motivation in Depression
Attaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal…
- Trial name
- NCT05120336
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Vagus Nerve Stimulations
Acute Cardiovascular Effects of Transcutaneous Auricular Vagus Nerve Stimulation
Introduction Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with arterial hypertension representing the most significant modifiable risk factor (Lim et al., 2012; Mills et al., 2020).
- Trial name
- NCT07501611
- Testing
- Active taVNS condition
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Rheumatoid Arthritis, Systemic Lupus Erythematosus
The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability
This interventional study aims to investigate the effect of deep breathing (DB) and transcutaneous electrical vagus nerve stimulation (tVNS) on heart rate variability (HRV) in healthy participants and patients with rheumatoid…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Healthy Participants
- Trial name
- NCT05157334
- Testing
- Non-invasive auricular electrical transcutaneous vagus nerve stimulation, Deep breathing
- Where
- Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Constipation-predominant Irritable Bowel Syndrome, Abdominal Pain
Effect of taVNS on Abdominal Pain and Other Symptoms in Constipation-predominant Irritable Bowel Syndrome
This study aims to investigate the effects and possible mechanisms of transcutaneous auricular vagal nerve stimulation (taVNS) on abdominal pain and other symptoms in patients with IBS-C.
- Trial name
- NCT05392439
- Testing
- taVNS
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tongji University
Parkinson Disease
The Effect and Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation on Gait Impairments in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients .
- Trial name
- NCT05561348
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Health, Subjective
Investigation of the Effect of Unilateral Right, Unilateral Left and Bilateral Applications of Transcutaneous Auricular Vagus Nerve Stimulation on Autonomic Nervous System Activity in Healthy People
The vagus nerve is one of the main components of the parasympathetic nervous system, which oversees a wide variety of important bodily functions, including mood control, immune response, digestion, and heart rate.
- Trial name
- NCT05370027
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Mild Cognitive Impairment
Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
Patients with amnestic mild cognitive impairment (MCI) often have compromised quality of life (QOL). Cognitive impairment is a major contributor to decrements in QOL and progression of MCI often leads to loss of independence and…
- Trial name
- TVNS MCI (NCT03359902)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- 3 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Florida
Vagus Nerve Stimulation, Autonomic Nervous System
Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz)…
- Conditions
- Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure
- Trial name
- AVNS-DRC (NCT07274332)
- Testing
- Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz, Pulsetto FIT™ - tcVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Healthy
Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels
The vagus or vagal nerve is a nerve that sends signals from the brain to other parts of the body to control involuntary functionm, including stomach function, and it is important to the regulation of insulin, C-peptide, and…
- Trial name
- TaVNS (NCT06597149)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Healthy Male and Female Volunteers
The Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Anxiety Responses and Emotional Regulation
The main aim of this study is to investigate whether transcutaneous auricular vagus nerve stimulation (taVNS) can reduce anxiety and have an effect on emotional regulations
- Trial name
- NCT07369908
- Testing
- taVNS on tragus of subjects with high trait anxiety, taVNS on earlobe of subjects with high trait anxiety, taVNS on tragus of subjects with no high trait anxiety
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Depression in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with depression.
- Trial name
- PD-D-taVNS (NCT07679529)
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sympathetic; Imbalance
Comparison of Heart Rate Variability Measurement on the Arm and Chest in Vagus Nerve Stimulation
Healthy participants will be included in this study by invitation and randomised into three groups. Participants in each group will receive bilateral transcutaneous vagus nerve stimulation with the same frequency, current transit…
- Trial name
- NCT07000175
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Esophageal Diseases
The Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Oesophageal Pain Hypersensitivity
We are evaluating the role of transcutaneous electrical vagal nerve stimulation in the prevention of oesophageal pain hypersensitivity using a validated human model in healthy volunteers.
- Trial name
- NCT02620176
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wingate Institute of Neurogastroenterology
Healthy
The Effects of taVNS on Inhibitory Control
The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.
- Trial name
- NCT05468385
- Testing
- Vagus nerve stimulation via tragus
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Stroke, Stroke Sequelae
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity.
- Conditions
- Stroke, Stroke Sequelae, Motor Activity
- Trial name
- NCT04130646
- Testing
- Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cognitive Function
The Effect of Transcutaneous Vagus Nerve Stimulation on Cognitive Function
Cognitive health is generally considered a key component of quality of life. Current evidence indicates that a large number of individuals are at a high risk for cognitive impairment from many causes as they age.
- Trial name
- NCT04070547
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- Czechia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ostrava