Clinical trials: Transfusion
Hemorrhage
Tranexamic Acid, Hemorrhage and Transfusions After Combined Aortic Valve Replacement and Coronary Artery Bypass Surgery.
In this study we will investigate whether tranexamic acid given as an intravenous bolus injection before start of surgery, followed by a continuous infusion during surgery reduces, perioperative hemostatic activation, and…
- Trial name
- NCT00375466
- Testing
- Tranexamic acid
- Where
- Norway
- Volunteers
- 63 people
- Sponsor
- St. Olavs Hospital
Red Blood Cell Transfusions, Anemia
Red Blood Cell Transfusion in the Ambulatory Setting: Impact on Home Functional Status
Do ambulatory RBC transfusions improve home functional status?
- Conditions
- Red Blood Cell Transfusions, Anemia, Hematology, Oncology
- Trial name
- NCT02835937
- Testing
- No-Transfuse
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Sickle Cell Anemia
Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea
The primary goal of the Phase III TWiTCH trial is to compare 24 months of alternative therapy (hydroxyurea) to standard therapy (transfusions) for pediatric subjects with sickle cell anemia and abnormally high (≥200 cm/sec)…
- Trial name
- TWiTCH (NCT01425307)
- Testing
- Hydroxyurea
- Volunteers
- 159 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Safety Issues;Effect of Drugs
Clinical Effect and Safety of Autologous Umbilical Cord Blood Transfusion in the Treatment of Autism Spectrum Disorder
To study the clinical efficacy and safety of autologous umbilical cord blood transfusion in the treatment of autism spectrum disorder.
- Trial name
- NCT04768816
- Testing
- 0.9% Sodium Chloride, Autologous Umbilical Cord Blood
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Guangdong Women and Children Hospital
Thrombocytopenia, Alloimmune Platelet Refractoriness
Complement Inhibition Using Eculizumab to Overcome Platelet Transfusion Refractoriness in Patients With Severe Thrombocytopenia
Background: Platelets are tiny cells in the blood that help stop bleeding. Thrombocytopenia happens when people do not have enough normal platelets.
- Trial name
- NCT02298933
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Valve Surgery
Application of Large Volume Acute Normovolemic Hemodilution in Cardiac Valve Surgery
The application of acute Normovolemic Hemodilution in cardiac surgery can effectively reduce perioperative blood transfusion, reduce postoperative complications and mortality, and is a low-cost, operable and effective blood…
- Trial name
- NCT03933917
- Testing
- Acute Normovolemic Hemodilution
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot Trial
The goal of this clinical trial is to establish the feasibility of conducting a large trial to determine the optimal timing of intravenous tranexamic acid administration in cardiac surgery.
- Conditions
- Bleeding, Surgical Blood Loss, Seizures
- Trial name
- DEPOSITION-2 (NCT06622564)
- Testing
- Before CPB Tranexamic Acid, After CPB Tranexamic Acid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Hamilton Health Sciences Corporation
Intracerebral Hemorrhage
Platelet Transfusion in Acute Intracerebral Hemorrhage
To prove whether use of antiplatelet agents results into a rapid enlargement of hematoma after onset of acute intracerebral hemorrhage.
- Trial name
- NCT00699621
- Testing
- platelets
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- University of Oulu
Myeloproliferative Disorders, Myelofibrosis
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus…
- Conditions
- Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
- Trial name
- INDEPENDENCE (NCT04717414)
- Testing
- ACE-536
- Where
- 185 sites in United States, Argentina and 24 more
- Volunteers
- 313 people
- Sponsor
- Celgene
Red Blood Cells, Preterm
Blood Transfusions in Preterm Infants
A cross sectional study to assess the effect of blood transfusions on the outcome of preterm infants
- Trial name
- NCT05331235
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Severe Aplastic Anemia
The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia
Aim: To evaluate if additional cord blood transfusion could accelerate the hematopoietic reconstitution in severe aplastic anemia(SAA) patients receiving immunosuppressive therapy (IST).
- Trial name
- NCT02745717
- Testing
- Thymoglobulin, Cord blood, Cyclosporine Oral Product
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Blood Transfusion Complication
Can we Transfuse Blood Over Shorter Period ?
Blood transfusion is very lengthy procedure and consumes a substantial time from patients and health care providers. On average, it may take most if not all the working day which leads to significant constrains on hospital bed…
- Trial name
- NCT03444610
- Testing
- Blood transfusion escalation rate
- Sponsor
- King Faisal Specialist Hospital & Research Center
Severe Malaria, Thrombocytopenia
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
- Trial name
- PLATFORM (NCT05711485)
- Testing
- Whole blood transfusion
- Where
- 2 sites in United States, Zambia
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Excessive Amount of Blood / Fluid Transfusion
Iron and Vitamin Adminstration Prior to Joint Replacement to Prevent Transfusion
To establish the efficacy of screening for anemia and treatment of mild anemia with iron and vitamins prior to THR and TKR as a means of increasing hemoglobin and reducing perioperative allogeneic blood transfusion.
- Trial name
- NCT01676740
- Testing
- Iron Supplement,
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Meir Medical Center
Transfusion-dependent β-thalassemia Patients
Evaluating the Clinical Efficacy and Safety of Luspatercept Combined With Thalidomide in the Treatment of β-TDT Patients
β-thalassemia is one of the most common inherited hemoglobinopathies worldwide and a major public health issue that severely impacts birth quality, human health, and social progress.
- Trial name
- NCT07338344
- Testing
- Luspatercept combined with low-dose thalidomide
- Where
- 8 sites in China
- Volunteers
- 78 people
- Sponsor
- Rongrong Liu
Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments
Hepatic Artery Transfusion of NKG2D CAR-NK Cells Followed by Intravenous Infusion of NKG2D CAR-T Cells to Treat Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments: a Phase I Exploratory Clinical Trial
This is a single-center, single-arm, open-label, dose-escalation clinical study to evaluate the safety and preliminary efficacy of NKG2D CAR-NK cells followed by NKG2D CAR-T cells in patients with advanced solid tumors…
- Trial name
- NCT07021534
- Testing
- NKG2D CAR NK and NKG2D CAR T cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhejiang University
Scheduled Surgery
Transfusion HeAd NecK Surgery
During elective surgery, the decision to transfuse a patient to correct anemia or an unstable hemodynamic state is often determined on a case by case basis according to personal and hospital transfusion practice.
- Trial name
- THANKS (NCT03910816)
- Where
- France
- Volunteers
- 377 people
- Sponsor
- University Hospital, Montpellier
ICU Anemia, Functional Iron Deficiency
Randomized Study Comparing Ferric Carboxymaltose to Iron Sucrose to Treat Fe Deficiency in the Surgically Critically Ill
Critically ill surgical patients are observed to have a functional iron deficiency which contributes to anemia, iron-deficient erythropoiesis, and an increased red blood cell transfusion requirement.
- Trial name
- NCT02009943
- Testing
- Ferric carboxymaltose, Iron sucrose
- Where
- United States
- Sponsor
- Denver Health and Hospital Authority
Preterm, Infant Death
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks…
- Trial name
- CORDMILK-PT (NCT06240715)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 800 people
- Sponsor
- Nemours Children's Clinic
Hip Fracture
The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.
- Trial name
- NCT00162617
- Testing
- Red blood cell transfusion
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Hvidovre University Hospital