Clinical trials: Transfusions
Hypoxia Neonatal, Premature
Pulse Oximetry Measurement and Transfusions
The primary purpose of this observational study was to determine if pRBC transfusions decrease the frequency of intermittent hypoxia events in very low birth weight infants (VLBW) during the first six weeks of life.
- Conditions
- Hypoxia Neonatal, Premature, Blood Transfusion
- Trial name
- POMAT (NCT04249193)
- Testing
- Transfusion
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Christiana Care Health Services
Gastric Cancer, Anemia, Iron Deficiency
Implementation of a Patient Blood Management Program in Gastric Cancer Surgery
Retrospective evaluation on a prospective cohort of patients undergoing curative gastric cancer resection to evaluate the impact of a patient blood management (PBM) program on transfusion rate and clinical outcomes.
- Conditions
- Gastric Cancer, Anemia, Iron Deficiency, Surgery--Complications, Transfusion Related Complication
- Trial name
- IPAT (NCT04286984)
- Testing
- unified protocol of Patient Blood Management measure
- Volunteers
- 1,063 people
- Sponsor
- Hospital Universitari de Bellvitge
Myeloid Malignancy, Bone Marrow Failure Syndrome
Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation
The purpose of this study is to find out what effects, good and/or bad, the addition of clofarabine, a new chemotherapy agent, to a standard busulfan and fludarabine conditioning treatment has.
- Conditions
- Myeloid Malignancy, Bone Marrow Failure Syndrome, Transfusion-dependent Red Blood Cell (RBC) Defect, Congenital Immunodeficiency
- Trial name
- NCT01596699
- Testing
- Alemtuzumab, Busulfan, Fludarabine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Blood Loss, Surgical, Transfusion
Blood Loss Evaluation Using a Novel Device
The study´s aim is to evaluate the clinical applicability of the Feature Extraction Technology (FET) during a simulated blood loss scenario.
- Conditions
- Blood Loss, Surgical, Transfusion, Patient Blood Management
- Trial name
- NCT04245995
- Testing
- Feature Extraction Technology
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
C.Surgical Procedure; Cardiac, Blood Transfusion
Cost-Utility Analysis of Management of Peri Operative Haemorrhage Following Cardiac Surgery With Cardiopulmonary Bypass
Peri operative haemorrhage following cardio Pulmonary Bypass may occur in 5 to 10% of cardiac surgical interventions. Treatment of such complication often necessitates various combinations therapeutic intervention including…
- Conditions
- C.Surgical Procedure; Cardiac, Blood Transfusion, Blood Coagulation Disorders, Bypass, Cardiopulmonary
- Trial name
- IMOTEC (NCT02972684)
- Testing
- Thrombo-elastometry POC testing
- Where
- 15 sites in France
- Volunteers
- 1,098 people
- Sponsor
- Nantes University Hospital
Transfusion-dependent Iron Overload
A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-dependent Iron Overload
This study uses a single arm, multi-center, open-label trial design. The study will assess the efficacy and safety of 52 weeks of treatment with deferasirox (ICL670) in patients with evidence of transfusion induced iron overload.
- Trial name
- NCT00171821
- Testing
- Deferasirox
- Where
- 97 sites in Australia, Austria and 21 more
- Volunteers
- 1,784 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplantation, Postoperative Renal Complication
Postoperative Complications After Liver Transplantation
Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver transplantation are not well defined.
- Conditions
- Liver Transplantation, Postoperative Renal Complication, Postoperative Pulmonary Complication, Postoperative Cardiovascular Complication
- Trial name
- NCT02761109
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Transfusion Reaction, Anemia
POOLED Red Blood Cells Prepared From Pooling 5 Leukoreduced, Irradiated RBC Units
The purpose of the study is to determine the safety of pooled red blood cells (RBCs) compared to standard leukoreduced RBC products stored in additive solution.
- Trial name
- Pooled RBCs (NCT03056378)
- Testing
- Standard RBCs
- Where
- United States
- Sponsor
- New York Blood Center
Anemia
INTERCEPT Safety Evaluation in Anemic Patients
The pathogen reduction (PR) system for Whole Blood (WB) using Amustaline (S-303) and Glutathione (GSH) has a potential to decrease transfusion-transmitted infection.
- Trial name
- POINT1africa (NCT03486054)
- Testing
- INTERCEPT, Standard of Care
- Sponsor
- Swiss Transfusion SRC
Healthy, Transfusion Reactions
Effects of Antibodies to White Blood Cells on Platelet Transfusion Patients
This study will determine if transfusion of platelets containing HLA antibodies (certain antibodies to white blood cells) are more likely to cause transfusion reactions than transfusion of platelets that do not contain HLA…
- Trial name
- NCT00460122
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Transfusion Related Complications
Clinic Trial for West China Perioperative Transfusion Score (WCPTS)
Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the…
- Trial name
- WCPTS (NCT01597232)
- Testing
- Transfusion trigger based on WCPTS, Maintenance of hemoglobin level more than 10g/dL, Transfusion trigger based on experience
- Where
- China
- Volunteers
- 1,351 people
- Sponsor
- West China Hospital
Post-partum Hemorrhage, Blood Transfusion
Risk Factors, Management and Complications of Severe Post-partum Hemorrhage
The incidence of severe post-partum hemorrhage has been increasing in developed countries. The reason for this is at least partially unknown.
- Trial name
- PPH-REG (NCT02815605)
- Where
- Finland
- Volunteers
- 9,000 people
- Sponsor
- Tampere University Hospital
Premature Birth of Newborn, Infant, Very Low Birth Weight
Delayed Cord Clamping in Preterm Neonates
Delayed cord clamping (DCC) from 30 to 60 seconds allows blood to continue to flow from the placenta through the umbilical cord to the infant, thus resulting in a placental transfusion.
- Conditions
- Premature Birth of Newborn, Infant, Very Low Birth Weight, Delayed Separation of Umbilical Cord, Placental Transfusion
- Trial name
- DCC (NCT02478684)
- Testing
- 30 Seconds of placental blood transfusion, 60 Seconds of placental blood transfusion
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Weill Medical College of Cornell University
Transfusion-dependent β-thalassemia Patients, Cardiac Iron Overload
Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron Overload
The primary efficacy endpoint of this interventional study was to evaluate the number of patients achieving a complete response (CR), defined as patients switching from intensive deferasirox -DFO treatment, at any time point…
- Trial name
- NCT01459718
- Testing
- Deferasirox, Deferoxamine (DFO)
- Where
- 4 sites in Greece
- Volunteers
- 32 people
- Sponsor
- Novartis Pharmaceuticals
Non-transfusion Dependent Thalassemia
Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent Thalassemia
Assessed the efficacy of deferasirox in patients with non-transfusion dependent thalassemia based on change in liver iron concentration from baseline after 52 weeks of treatment.
- Trial name
- THETIS (NCT01709838)
- Testing
- deferasirox
- Where
- 11 sites in China, Greece and 6 more
- Volunteers
- 134 people
- Sponsor
- Novartis Pharmaceuticals
Mitral Valve Replacement, Transfusion Reaction
Blood Transfusion Management in Patients With Mitral Valve Replacement in China
The evaluation uses ΔHb as an independent factor combined with artificial intelligence (AI) to predict its impact on the prognosis and blood transfusion of patients undergoing cardiac surgery, thereby guiding perioperative…
- Conditions
- Mitral Valve Replacement, Transfusion Reaction, Blood Transfusion Complication
- Trial name
- NCT03885570
- Testing
- Mitral valve replacement
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Sickle Cell Disease, Pregnancy, High Risk
TAPS2 Transfusion Antenatally in Pregnant Women With SCD
Sickle Cell Disease (SCD) is a serious inherited blood disorder affecting red blood cells. When oxygen levels drop the red cells become abnormally shaped and unable to move through the blood vessels easily.
- Conditions
- Sickle Cell Disease, Pregnancy, High Risk, Blood Transfusion Complication
- Trial name
- TAPS2 (NCT03975894)
- Testing
- Serial prophylactic exchange blood transfusion (SPEBT).
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Knee Osteoarthritis, Blood Clot
Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement.
This study compares two oral medications (tranexamic acid and aminocaproic acid) as hemostatic agent administered in patients undergoing total knee replacement.
- Conditions
- Knee Osteoarthritis, Blood Clot, Transfusion Related Complication, Blood Loss
- Trial name
- NCT03365999
- Testing
- Oral Tranexamic Acid, Oral Aminocaproic Acid
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Platelet Transfusion, Hematological Malignancy
Comprehensive Study of Social Representation of Platelet Transfusion in Patients Followed for Advanced Hematological Malignancies (R-PLQ)
Limited data is available for end of life care in hematologic malignancies, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its…
- Conditions
- Platelet Transfusion, Hematological Malignancy, Palliative Care
- Trial name
- R-PLQ (NCT03806712)
- Testing
- multi method questionary (developped by De Rosa, in 1995 and 2014)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Platelet Transfusion, Critical Illness
Platelet Transfusions in Critically Ill Patient
Between 10 and 15% of critically ill patients require platelet transfusion within their intensive care unit (ICU). Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat bleeding as part of massive…
- Trial name
- RE-CCIP (NCT03325140)
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest