Clinical trials: Transfusions
Non-transfusion-dependent Thalassemia, Low Risk Myelodysplastic Syndrome
A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome
This study will investigate the safety and tolerability of SLN124 in patients with Thalassaemia or patients with Very Low- and Low-risk Myelodysplastic Syndrome (MDS) after single ascending s.c.
- Conditions
- Non-transfusion-dependent Thalassemia, Low Risk Myelodysplastic Syndrome, Very-Low Risk Myelodysplastic Syndrome
- Trial name
- NCT04718844
- Testing
- SLN124
- Where
- 20 sites in Germany, Israel and 5 more
- Volunteers
- 44 people
- Sponsor
- Silence Therapeutics plc
Sickle Cell Disease, Hemoglobin SC
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOP
Patients are being asked to participate in this study because they have severe sickle cell anemia (SCD) with or without the beta thalassemia trait.
- Trial name
- SCALLOP (NCT00578344)
- Testing
- Busulfan, Campath 1H, Cyclophosphamide and MESNA
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Tami D. John
Anemia
INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections
To evaluate the safety and efficacy of red blood cells (RBCs) prepared with the INTERCEPT Blood System for Red Blood Cells Pathogen Reduction Treatment (PRT) in comparison to conventional RBCs in patients who require RBC…
- Trial name
- RedeS (NCT03037164)
- Testing
- INTERCEPT Blood System for Red Blood Cells, Conventional (Control)
- Where
- 16 sites in United States, Puerto Rico and 1 more
- Volunteers
- 692 people
- Sponsor
- Cerus Corporation
Cyanotic Congenital Heart Disease, Anemia
Erythropoietin to Prevent Unnecessary Transfusions In Patients With Cyanotic CHD - A Prospective Control Trial
Cyanotic congenital cardiac patients require higher hemoglobin concentrations (red blood cell levels) for optimal oxygen delivery to the body.
- Conditions
- Cyanotic Congenital Heart Disease, Anemia, Cyanosis, Congenital Heart Disease
- Trial name
- NCT02564796
- Testing
- Epoetin Alfa and Iron, Iron
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Diego
Hemorrhage
Safety and Efficacy of Intravenous Tranexamic Acid in Endoscopic Transurethral Resections in Urology
Transurethral resection of the prostate (TURP) represents the gold standard in the operative management of benign prostatic hyperplasia (BPH) and the transurethral resection of bladder tumor (TURBT) is the first-line surgical…
- Trial name
- NCT02653261
- Testing
- Tranexamic Acid
- Where
- Tunisia
- Volunteers
- 131 people
- Sponsor
- University Tunis El Manar
Surgery, Erythrocyte Transfusion
European Transfusion Practice and Outcome Study
The aim of the ETPOS study is to describe differences in transfusion habits throughout Europe and to correlate these habits to perioperative outcome parameters.
- Conditions
- Surgery, Erythrocyte Transfusion, Habits, Anemia
- Trial name
- ETPOS (NCT01604083)
- Where
- 9 sites in Croatia, Czechia and 6 more
- Volunteers
- 6,066 people
- Sponsor
- European Society of Anaesthesiology
Cancer of the Bone, Limb Salvage
Tranexamic Acid Use to Reduce Blood Transfusion in Pediatric Cancer Patients Undergoing Limb Salvage Procedure
This is a randomized double-blind control trial evaluating the use Tranexamic acid (TXA) to decrease blood loss and transfusion requirements in pediatric and young adult cancer patients undergoing a limb salvage procedure that…
- Trial name
- NCT04410042
- Testing
- Tranexamic Acid, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Jude Children's Research Hospital
Acute on Chronic Liver Failure, Variceal Hemorrhage
Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy
In this project, we plan to evaluate whether a new, rotational thromboelastometry-guided algorithm (ROTEM) to guide hemostatic resuscitation decreases the use of allogeneic blood products, the total amount of bleeding…
- Conditions
- Acute on Chronic Liver Failure, Variceal Hemorrhage, Cirrhosis, Liver, Thromboelastometry
- Trial name
- GOODHEART-ACLF (NCT05124041)
- Testing
- Rotational thromboelastometry
- Where
- India
- Volunteers
- 262 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Anemia, Low Birth Weight
Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women
The purpose of this research is to compare the efficacy of two low-cost low intervention packages to prevent and treat severe anemia in pregnant women in Zanzibar, Tanzania.
- Conditions
- Anemia, Low Birth Weight, Neonatal Mortality
- Trial name
- NCT00148629
- Testing
- multivitamin, mebendazole
- Where
- Tanzania
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Cornell University
Cardiac Surgery, Transfusion
Transfusion Savings in Heart Surgery: Impact of Individual Strategy by Erythropoietin and Metabolic Adjustment (ScvO2)
Preoperative anemia, bleeding and transfusions have been recognized as a "Deadly triad" in cardiac surgery associated with an increased morbidity,mortality, and costs related.
- Conditions
- Cardiac Surgery, Transfusion, Perioperative Anemia
- Trial name
- BLOOCOST (NCT04141631)
- Testing
- EPO (600UI/Kg, sub-cutaneous) and Ferric Carboxymaltose (FCM) (20 mg/kg in 250 mL of saline solution 0.9% over 15 min)
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Montpellier
Neonatal Anemia
Optimized Erythropoietin (EPO) Treatment
Neonatal anemia is the most commonly encountered hematologic problem among all neonates cared for in the neonatal intensive care unit (NICU).
- Trial name
- OETNA (NCT02075970)
- Testing
- Epoetin Alpha
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Iowa
Bleeding in Liver Transplantation
Plasma Transfusion in Liver Transplantation
The aim of the study is to compare the clinical efficacy of three types of plasma secured on the viral level either by quarantine or by chemical treatment in patients undergoing liver transplantation.
- Trial name
- NCT00235183
- Testing
- plasma
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Etablissement Français du Sang
Healthy Volunteers
Adverse Effects of RBC Transfusions: A Unifying Hypothesis
Transfusion of red blood cells is often used in critically ill patients with low red blood cell counts to prevent disease progression and death.
- Trial name
- INOBA (NCT00838331)
- Testing
- Fresh blood, Aged blood
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emory University
Thrombocytopenia
Effects of a Platelet Transfusion Best Practices Alert
This study is to determine the effectiveness of a computerized clinical decision support tool (Best Practice Alert - BPA) in reducing unnecessary platelet transfusions based on guidelines published by national transfusion…
- Trial name
- NCT04155775
- Testing
- Computer electronic health record alert (Best Practice Alert - BPA)
- Where
- United States
- Volunteers
- 446 people
- Sponsor
- Stanford University
Hereditary Anemias
Utility of Fibroscan in Estimating Hepatic Iron Concentration
In patients with hereditary anemias (e.g. thalassemias), defective red blood cells are produced due to an error in the genes, or DNA, that provide the instructions for their synthesis.
- Trial name
- NCT02067130
- Testing
- Fibroscan
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Bleeding
Massive Transfusion Protocol With Coagulation Algorithm
In 2008 at the University Hospital Zurich (USZ) a massive transfusion protocol was introduced. Based on laboratory diagnostics and point of care (POC) devices including ROTEM.
- Trial name
- NCT02350101
- Testing
- Rotational thromboelastometry
- Volunteers
- 243 people
- Sponsor
- University of Zurich
Myelodysplastic Syndromes
Physical Activity in Transfusion Dependent Patients With Myelodysplastic Syndrome
This study assesses feasibility and patient acceptability of using a Fitbit to monitor step count and heart rate in transfusion dependent patients with myelodysplastic syndrome.
- Trial name
- NCT04969367
- Testing
- Medical Device Usage and Evaluation, Biospecimen Collection, Questionnaire Administration
- Where
- United States
- Sponsor
- Thomas Jefferson University
Myeloid Malignancy, Bone Marrow Failure Syndrome
Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation
The purpose of this study is to find out what effects, good and/or bad, the addition of clofarabine, a new chemotherapy agent, to a standard busulfan and fludarabine conditioning treatment has.
- Conditions
- Myeloid Malignancy, Bone Marrow Failure Syndrome, Transfusion-dependent Red Blood Cell (RBC) Defect, Congenital Immunodeficiency
- Trial name
- NCT01596699
- Testing
- Alemtuzumab, Busulfan, Fludarabine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Immune Tolerance
Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation
This research study is to determine if donor blood stem cells given after living, related, HLA antigen (Ag) haplotype match or living, unrelated donor kidney transplantation.
- Trial name
- CIRM (NCT03292445)
- Testing
- Immune tolerance after kidney transplant, Donor blood stem cells and T cells
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Strober
Cirrhosis, Liver
Rotational Thromboelastometry Guided Blood Component Use in Children With Cirrhosis Undergoing Invasive Procedures: A Randomized Controlled Trial
Blood products are commonly used before invasive procedures in patients with end-stage liver diseases despite cirrhosis being a thrombophilic state.
- Trial name
- NCT04460222
- Testing
- Rotational Thromboelastometry to guide blood product transfusion pre invasive procedure, Conventional transfusion methods to guide blood product transfusion pre invasive procedure
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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