Clinical trials: Transfusions
Beta-thalassemia Major, Hemosiderosis
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)
To allow patients treated with deferasirox in the core study to continue iron chelation therapy for 2 years or until the drug became locally commercially available.
- Conditions
- Beta-thalassemia Major, Hemosiderosis, Iron Overload, Rare Anemia
- Trial name
- ESCALATOR (NCT00171301)
- Testing
- Deferasirox
- Where
- 5 sites in Egypt, Lebanon and 3 more
- Volunteers
- 233 people
- Sponsor
- Novartis Pharmaceuticals
Myelodysplastic Syndrome
Treatment of Myelodysplastic Syndromes Comparing Hydralazine/Ac. Valproic and Supportive Care in Patients Not Candidates, Refractory and/or Intolerant to Intensive Chemotherapy
Transfusional dependence has been associated closely and independently with low survival in patients with myelodysplastic syndrome (MDS), especially in patients at low risk according to IPSS.
- Trial name
- NCT01356875
- Testing
- BSC, HIDRA/VPA
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Basque Health Service
Acute Myeloid Leukaemia
Transfusion Dependency at Diagnosis and Transfusion Intensity During Initial Chemotherapy Are Associated With Poorer Outcomes in Adult Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is a haematological malignant disease characterized by an uncontrolled proliferation of immature hematopoietic cells.
- Trial name
- NCT02844257
- Where
- France
- Volunteers
- 1,067 people
- Sponsor
- Hospices Civils de Lyon
Sickle Cell Disease, Pregnancy Related
Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease
The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of…
- Trial name
- ProTIP (NCT06979492)
- Testing
- Prophylactic Transfusion Intervention group: Transfusion, Control group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
Evaluation of Azacitidine in Transfusion Dependent Patients With Low-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)
Azacitidine has proved prolonged overall survival in patients with high-risk MDS. Minor pilot studies have shown that treatment with Azacitidine can induce transfusion independency in previous transfusion dependent patients with…
- Trial name
- NCT01048034
- Testing
- Azacitidine, Erythropoetin
- Where
- 17 sites in Denmark, Norway and 1 more
- Volunteers
- 30 people
- Sponsor
- Nordic MDS Group
Acute Lung Injury
Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children
Transfusions cause more adverse events in children than in adults. Patients in pediatric intensive care units (PICU) are particularly exposed to transfusions of plasma-rich blood products (red blood cell (RBC), plasma and…
- Trial name
- TRALI (NCT02613377)
- Testing
- Blood transfusion
- Where
- 4 sites in Canada
- Volunteers
- 717 people
- Sponsor
- St. Justine's Hospital
Sepsis, Sepsis and Coagulopathy
Sepsis-associated Thrombocytopenia and Platelet Transfusion （STAPT）
Currently, there are no multicenter studies on platelet transfusion for SAT patients, and the benefits and risks of platelet transfusion still require further validation based on large-sample data.
- Trial name
- NCT07230067
- Testing
- SAT patients
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Beta-Thalassemia, Thalassemia
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
This is a single-dose, open-label study in pediatric participants with TDT. The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (CTX001).
- Conditions
- Beta-Thalassemia, Thalassemia, Genetic Diseases, Inborn, Hematologic Diseases
- Trial name
- NCT05356195
- Testing
- CTX001
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 16 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Graft Versus Host Disease, Hyperkalemia
Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair
Blood transfusions are required for patients undergoing a craniosynostosis repair due to the significant amount of blood loss. Irradiated or non-irradiated transfusions have many risks involved including elevated potassium levels…
- Conditions
- Graft Versus Host Disease, Hyperkalemia, Craniectomy, Synostectomy
- Trial name
- NCT02483702
- Testing
- Irradiated Blood Transfusions, Non-Irradiated Blood Transfusions
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Anemia, Age Problem
Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients
The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion.
- Conditions
- Anemia, Age Problem, Ultrasonography
- Trial name
- Trans-US (NCT06060639)
- Testing
- transthoracic echocardiography
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Blood Transfusion Complication
Can we Transfuse Blood Over Shorter Period ?
Blood transfusion is very lengthy procedure and consumes a substantial time from patients and health care providers. On average, it may take most if not all the working day which leads to significant constrains on hospital bed…
- Trial name
- NCT03444610
- Testing
- Blood transfusion escalation rate
- Sponsor
- King Faisal Specialist Hospital & Research Center
Thalassemia Major
Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation
This study is a multicenter, open-label, two-period crossover design that evaluates the safety, tolerability, pharmacokinetics and preliminary evidence of iron chelating activity of DST-0509 as compared to Jadenu and Exjade in…
- Trial name
- NCT03637556
- Testing
- DST-0509, Jadenu, Exjade
- Where
- 4 sites in United States, Thailand
- Volunteers
- 25 people
- Sponsor
- DisperSol Technologies, LLC
Transfusion-dependent β-thalassemia Patients, Cardiac Iron Overload
Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron Overload
The primary efficacy endpoint of this interventional study was to evaluate the number of patients achieving a complete response (CR), defined as patients switching from intensive deferasirox -DFO treatment, at any time point…
- Trial name
- NCT01459718
- Testing
- Deferasirox, Deferoxamine (DFO)
- Where
- 4 sites in Greece
- Volunteers
- 32 people
- Sponsor
- Novartis Pharmaceuticals
Cardiac Surgery, Erythrocyte Transfusion
Impact of Blood Storage Duration on Physiologic Measures
This study is an ancillary (add-on) study to the clinical trial entitled Red Cell Storage Duration Study (RECESS), which has clinicaltrials.gov identifier NCT00991341.
- Trial name
- RECAP (NCT01274390)
- Where
- 4 sites in United States
- Volunteers
- 390 people
- Sponsor
- Duke University
Arthritis of the Hip, Transfusion Related Complications
Preoperative Versus Postoperative Start With Thromboprophylaxis in THA (Total Hip Arthroplasty)
The purpose of this study is to determine if there are differences in clinical events, i.e bleeding with associated morbidity, if thromboprophylaxis with LMWH (Low Molecular Weight Heparin) is initiated before or after surgery.
- Conditions
- Arthritis of the Hip, Transfusion Related Complications, Infection, Wound Discharge
- Trial name
- NCT01714297
- Testing
- dalteparin 5000 IU s.c.
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Glanzmann Thrombasthenia
Anti-αIIbβ3 Immunization in Glanzmann Thrombasthenia: Prevalence and Associated Risk Factors: Thrombasthenia Anti-αIIbβ3 Antibodies Study (TAAS)
This project aim to correlate risk factors (genetic, therapeutic and socio-demographic factors) to anti-αIIbβ3 antibodies formation following blood products transfusion (platelets or packed red cells) or pregnancy in a national…
- Trial name
- TAAS (NCT04595617)
- Testing
- Antibodies screening
- Where
- 7 sites in France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Bordeaux
Iron Overload, Transfusion-dependent Thalassemia
Endocrine Function During Deferasirox Therapy
A national survey on the prevalence and natural history of endocrine complications in thalassemia transfusion--dependent patients treated with deferasirox was designed, in order to assess a larger population during a longer…
- Conditions
- Iron Overload, Transfusion-dependent Thalassemia, Endocrine; Complications
- Trial name
- NCT04515680
- Where
- Italy
- Volunteers
- 426 people
- Sponsor
- University of Campania Luigi Vanvitelli
Anemia
Iron Prophylaxis for Anemia in Infants With Cyanotic Congenital Heart Disease
Anemia is a common disorder in infants with one working chamber of the heart that pumps blood. Anemia is when the level of healthy blood cells becomes too low.
- Trial name
- NCT00459225
- Testing
- Iron (ferrous sulfate)
- Where
- United States
- Sponsor
- Emory University
Thrombocytopenia
Transfusing Neonates Based on Platelet Mass
Thrombocytopenia (low platelet count) is common in the neonatal intensive care unit. Commonly, the decision of when to transfuse platelets is based on platelet number.
- Trial name
- NCT00759980
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Christiana Care Health Services
Non Traumatic Splenic Rupture
Non-traumatic Rupture of the Spleen. Can Splenectomy be Applied Selectively?
Purpose: Non-traumatic rupture of the spleen should be suspected when patients (especially young men) present with abdominal pain and a history of acute infectious or myeloproliferative disorders.
- Trial name
- NCT01845662
- Testing
- Surgical or non-surgical management
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Ziv Hospital
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