Clinical trials: Transfusions
Coagulopathy, Blood Transfusion Complication
Thromboelastography Normal Reference Values in China Hunan Province
The purpose of this study was to establish the normal reference range of Thrombelastogram parameters in Hunan by a multicenter study, and to analyze the specificity of Thrombelastogram detection and the influence of gender, age…
- Trial name
- NCT03146455
- Testing
- no intervention
- Where
- China
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Twin to Twin Transfusion Syndrome, Congenital Diaphragmatic Hernia
Automated Myocardial Performance Index Using Samsung HERA W10
Researchers are using Myocardial performance index (MPI) to assess fetal cardiac function before, during, and after fetal surgery in order to gain more knowledge about fetal cardiac function in high risk pregnancies and the…
- Conditions
- Twin to Twin Transfusion Syndrome, Congenital Diaphragmatic Hernia, Neural Tube Defects, Lower Urinary Tract Infection
- Trial name
- NCT04140669
- Testing
- Automated Myocardial Performance Index (MPI)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Healthy Volunteer Red Blood Cell Labeling Study; Not Disease Focused
Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion
This research is being done to compare the red blood circulation survival in healthy adult volunteers between the 51 chromium (51Cr) red blood cell (RBC) labeling method and the Biotin (BioRBC) red blood cell (RBC) labeling…
- Trial name
- NCT07446647
- Testing
- Biotinylated Red Blood Cells (BioRBC), Irradiated Biotinylated Red Blood Cells (Irradiated BioRBC), 51 Chromium Labeled Red Blood Cells (51Cr RBC)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jose Cancelas
Chronic Granulomatous Disease, Infection
NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)
Background: CGD is caused by a gene mutation. For people with CGD, their cells cannot kill germs well, so they can get frequent or life-threatening infections.
- Trial name
- NCT05189925
- Testing
- gp91 Grans
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
Database of Monochorionic Pregnancies
The purpose of this study is to collect and analyze data regarding natural history, indications for fetal interventions, and maternal and fetal/neonatal outcomes associated with complicated monochorionic twin pregnancy.
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Twin; Complicating Pregnancy, Twin to Twin Transfusion Syndrome
- Trial name
- NCT05543499
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Miami
Anemia
ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion
The purpose of this study is to determine if there is a difference in outcomes between liberal transfusion (transfusing when hemoglobin drops below a set higher value number) and conservative transfusion (transfusing when…
- Trial name
- ORACL (NCT02972593)
- Testing
- Blood and blood products for transfusion
- Volunteers
- 161 people
- Sponsor
- Indiana University
Sickle Cell Disease, Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies
A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine that uses genetic material (mostly DNA) from the patient to treat his or her own disease.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0), Beta-Thalassemia, Transfusion Dependent Beta-Thalassaemia
- Trial name
- NCT06647979
- Testing
- autologous bone marrow derived CD34+ HSPCs electroporated with BCL11A enhancer targeting Cas9 ribonucleoprotein, Sequencing Assay for Variant rs114518452
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Daniel Bauer
Premature Infant, Umbilical Cord
Umbilical Cord Milking vs Delayed Cord Clamping in Preterm Infants Born by Cesarean Section
The purpose of this study is to determine whether the umbilical cord milking in preterm infants born by cesarian section less than 34 weeks is more effective than delayed cord clamping to obtain higher levels of hemoglobin.
- Conditions
- Premature Infant, Umbilical Cord, Milking, Delayed Clamping
- Trial name
- NCT02187510
- Testing
- Umbilical cord milking, Delayed cord clamping
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Anemia of Prematurity
Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants
To compare the effect of restrictive versus liberal red blood cell transfusion thresholds on long-term neurodevelopmental outcome in extremely low birth weight infants.
- Trial name
- ETTNO (NCT01393496)
- Testing
- red blood cell transfusion
- Where
- 32 sites in Denmark, Germany
- Volunteers
- 1,013 people
- Sponsor
- University Hospital Tuebingen
Pregnant With Complication
Feto-Fetal Transfusion Syndrome in Multiple Pregnancies
Objectives: Twin-to-twin transfusion syndrome (TTTS) generates high risk for one of the twins, may lead to preterm delivery and is also associated with neurodevelopmental deficits.
- Trial name
- NCT04148859
- Testing
- amnioreduction
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sickle Cell Disease, Transfusion-dependent Beta-Thalassemia
A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301
The purpose of this study is to evaluate the long-term safety and efficacy of EDIT-301 in participants with severe sickle cell disease (SCD) or transfusion-dependent β-thalassemia (TDT) who have received EDIT-301.
- Conditions
- Sickle Cell Disease, Transfusion-dependent Beta-Thalassemia, Hemoglobinopathies
- Trial name
- NCT06363760
- Testing
- Safety and efficacy assessments
- Where
- 18 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Editas Medicine, Inc.
Twin Twin Transfusion Syndrome
Renal Artery Dopplers in Twin Twin Transfusion Syndrome
Twin-twin transfusion syndrome (TTTS) is a complication affecting 10-15% of monochorionic, diamniotic (MCDA) twin pregnancies. Unevenly distributed blood flow across a shared placental circulation results in a volume-restricted…
- Trial name
- NCT03449823
- Testing
- Doppler ultrasound of fetal renal artery
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Sickle Cell Disease, Thalassemia
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused Recipients
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused recipients (RBC-IMPACT) is an observational cohort study to assess donor, component, and recipient factors that contribute to RBC efficacy in chronically and…
- Conditions
- Sickle Cell Disease, Thalassemia, Pediatric Cancer
- Trial name
- RBC-IMPACT (NCT05255445)
- Testing
- Red Blood Cell (RBC) Transfusion
- Where
- 14 sites in United States, Brazil
- Volunteers
- 157 people
- Sponsor
- Westat
Individualized Transfusion Strategy, Red Blood Cell
Individualized Strategies of Red Blood Cell Transfusion for Perioperative Pediatric Patients
The individualized strategies of red blood cell for perioperative pediatric patients are made based on the comparison between the clinical condition score and the Hb concentration.
- Conditions
- Individualized Transfusion Strategy, Red Blood Cell, Perioperative Pediatric Patient, Clinical Outcome
- Trial name
- NCT04537000
- Testing
- clinical condition score
- Sponsor
- Children's Hospital of Fudan University
Disorder Related to Renal Transplantation, Transfusion Reaction
Old Red Blood Cell In Renal Transplantation
Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population.
- Trial name
- ORBIT (NCT02841111)
- Volunteers
- 12,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Blood Platelet Transfusion, Blood Clotting
Study to Reveal if Fibrinogen Treatment Effects Blood Clotting Better Than a Platelet Transfusion
Patients with need of platelet transfusion for any reason will participate in this study. Directly before the start of infusion and one hour after the end of platelet transfusion blood samples will be drawn and treated with…
- Trial name
- FiT2012 (NCT01955811)
- Testing
- Administration of platelet concentrate and taking blood samples
- Where
- 5 sites in Austria, Denmark
- Volunteers
- 130 people
- Sponsor
- Medical University Innsbruck
Critical Care, Anemia
Insufficient Cellular Oxygen in ICU Patients With Anaemia
The purpose of this study is whether the mitochondrial oxygenation tension (mitoPO2) is a feasible and reliable tool in ICU patients with anaemia undergoing red cell transfusion to ultimately personalize blood transfusion…
- Conditions
- Critical Care, Anemia, Erythrocyte Transfusion, Oxygen
- Trial name
- INOX ICU-2 (NCT03092297)
- Where
- 2 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Severe Anaemia
Study of Safe Blood Transfusion Volumes to Correct Acute Severe Anaemia
Greater volume of whole blood(30mls/kg compared to 20mls/kg) following standard calculations, given to children with severe anaemia will be beneficial in haematological correction and can be given safely since respiratory…
- Trial name
- Tx30 (NCT01461590)
- Testing
- Whole blood
- Where
- 2 sites in Uganda
- Volunteers
- 160 people
- Sponsor
- Prof Kathryn Maitland
Gastrointestinal Hemorrhage
Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding
The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements.
- Trial name
- NCT01005147
- Testing
- tranexamic acid
- Sponsor
- University of Oklahoma
Resectable Pancreatic Carcinoma
Red Blood Cell Transfusion Thresholds for Improved Quality of Life for Patients Undergoing a Pancreatectomy for Pancreatic Cancer
This clinical trial tests the the feasibility of testing a red blood cell transfusion threshold for improved quality of life for patients undergoing a pancreatectomy for pancreatic cancer.
- Trial name
- NCT05841706
- Testing
- Arm I Packed Red Blood Cell Transfusion (Hgb < 7 g/dL), Arm II Packed Red Blood Cell Transfusion (Hgb < 9 g/dL), Computed Tomography
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Jonsson Comprehensive Cancer Center
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