Clinical trials: Transfusions
Acquired Immunodeficiency Syndrome, Blood Transfusion
Viral Activation Transfusion Study (VATS)
The purpose of the trial was to determine if transfusion of allogeneic blood to HIV-1 infected persons led to immune activation and consequent induction of HIV-1 or /or Cytomegalovirus (CMV) replication, and whether this…
- Conditions
- Acquired Immunodeficiency Syndrome, Blood Transfusion, Cytomegalovirus Infections, HIV Infections
- Trial name
- NCT00000593
- Testing
- blood transfusion
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage: Red Blood Cell Transfusion and Outcome
The purpose of this study is to determine the feasibility of conducting a large trial examining the effect on clinical outcome of a liberal red blood cell (RBC) transfusion strategy compared to a restrictive strategy (usual care)…
- Trial name
- SAHaRA Pilot (NCT02483351)
- Testing
- Liberal Red Blood Cell Transfusion Strategy, Restrictive Red Blood Cell Transfusion Strategy
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Recurrent Urinary Tract Infection, Safety Issues
Controlled Human Urine Transfusion for UTI
The primary objective of this pilot study is to investigate the safety and tolerability of controlled human urine transfusion in female patients with recurrent UTI's.
- Trial name
- SHUTUP (NCT03142295)
- Testing
- urine transfusion
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Leiden University Medical Center
Traumatic Brain Injury, Subarachnoid Hemorrhage
Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients
Neurocritical ill patients are frequently transfused. Red blood cell transfusion (RBCT) in these patients has been associated with deleterious effects, including higher rates of nosocomial infections, multi-organ failure, and…
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT00566709
- Testing
- Red blood cells transfusion
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Healthy
Feasibility Study of Mirasol-Treated Whole Blood Red Cell Recovery and Survival
Feasibility trial to evaluate recovery and survival of red blood cells (RBCs) from Mirasol-treated whole blood
- Trial name
- IMPROVE (NCT00742001)
- Testing
- Mirasol System for Whole Blood.
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio
Primary Myelofibrosis, MPN-associated Myelofibrosis
Study of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion-Dependence
The objective of this study is to determine whether pomalidomide is safe and effective in reversing red blood cell (RBC)-transfusion-dependence in persons with myeloproliferative neoplasm (MPN)-associated myelofibrosis (global…
- Trial name
- RESUME (NCT01178281)
- Testing
- Pomalidomide 0.5 mg, Pomalidomide
- Where
- 87 sites in United States, Australia and 14 more
- Volunteers
- 267 people
- Sponsor
- Celgene
Allogenic Transfusion, Perioperative Anaemia
Cross Iron (Comparative Randomized Oral Versus Systemic IRON)
Patients were recruited at the scheduled preoperative visit for hip or knee arthroplasty. If the haemoglobin (Hb) level was below 13 g/dl with no contraindication to iron supplementation the patients were randomized to the oral…
- Conditions
- Allogenic Transfusion, Perioperative Anaemia, Knee Arthroplasty, Hip Arthroplasty
- Trial name
- Cross Iron (NCT02496377)
- Testing
- ferrous glycine sulfate Tardyferon, Epoetin Alfa, ferric carboxymaltose Ferinject
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Myocardial Infarction
Myocardial Ischemia and Transfusion
MINT: A pilot, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in patients with myocardial infarction.
- Trial name
- MINT (NCT02619136)
- Testing
- Transfusion
- Where
- 4 sites in Canada
- Volunteers
- 3,501 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Transfusion Related Complication
Transfusion Strategy in Hematological Intensive Care Unit
Patients with acute hematological disease (acute leukemia, aplastic anemia, hematopoietic stem cells autologous or allogeneic ...) and hospitalized in an intensive care unit hematology require compensation of anemia and…
- Trial name
- 1VERSUS2CGR (NCT02461264)
- Testing
- Single red blood packed cells Transfusion, Two packed red blood cells Transfusion
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Caen
Blood Transfusion, Infection
Granulocyte Transfusion Study
To evaluate granulocyte transfusion therapy with respect to its prophylactic and therapeutic effectiveness to prevent and aid recovery from infection. The study trials were conducted simultaneously.
- Trial name
- NCT00000581
- Testing
- leukocyte transfusions
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Aneurysm, Abdominal, Arterial Occlusive Diseases
Plasma Transfusion in Major Vascular Surgery
BACKGROUND Major blood loss is frequent in open repair of ruptured and intact abdominal aortic aneurysm (AAA) as well as in aorto-bifurcated prosthesis insertion due to aortoiliac occlusive disease.
- Trial name
- NCT04514575
- Testing
- Plasma transfusion
- Where
- Denmark
- Volunteers
- 17,000 people
- Sponsor
- Naestved Hospital
Disorder Related to Renal Transplantation, Transfusion Reaction
Old Red Blood Cell In Renal Transplantation
Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population.
- Trial name
- ORBIT (NCT02841111)
- Volunteers
- 12,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Lupus Nephritis
Mesenchymal Stem Cell Transfusion for the Treatment of Refractory Lupus Nephritis
Lupus nephritis (LN) is the most common and serious complication of systemic lupus erythematosus (SLE), which can lead to permanent kidney injury and uremia.
- Trial name
- LN (NCT06485648)
- Testing
- Umbilical cord mesenchymal stem cells, Normal saline
- Volunteers
- 96 people
- Sponsor
- Chinese PLA General Hospital
Anaemia
Preoperative Intravenous Iron to Treat Anaemia in Major Surgery
Anaemia is a common problem in patients undergoing surgery. About half of patients undergoing a major operation have anaemia, often a consequence of the disease requiring surgery. Anaemia causes patients to feel tired and unwell.
- Trial name
- PREVENTT (NCT01692418)
- Testing
- Ferric carboxymaltose, Normal saline
- Where
- 28 sites in United Kingdom
- Volunteers
- 487 people
- Sponsor
- University College, London
Tranexamic Acid, Trauma
Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery
This study was done to evaluate the efficacy of Tranexamic Acid (TXA) in reducing blood transfusion requirement in patients of lower limb trauma undergoing surgery.
- Conditions
- Tranexamic Acid, Trauma, Lower Extremity Fracture
- Trial name
- NCT04986813
- Testing
- Tranexamic acid injection, Normal Saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Jaspreet Singh
Premature Birth
The Trial of Pessary After Laser for TTTS
Placing a cervical pessary in severe twin-to-twin transfusion syndrome (TTTS) cases treated by fetoscopic laser coagulation (FLC) decreases the spontaneous preterm birth rate.
- Trial name
- PECEPLASER (NCT01334489)
- Testing
- Arabin Cervical Pessary
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 352 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Degenerative Joint Disease, Osteoarthritis
Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)
You are being asked to take part in this research study because you are scheduled to have total hip replacement (arthroplasty) surgery.
- Trial name
- NCT01391182
- Testing
- EACA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Non-idiopathic Scoliosis
Non-Idiopathic Scoliosis Treated With Tranexamic Acid
Investigation of tranexamic acid (TXA) for reducing perioperative blood loss and transfusion requirement in pediatric patients with secondary scoliosis undergoing posterior spinal fusion.
- Trial name
- NCT01089140
- Testing
- Tranexamic acid 10mg/kg/hr, Tranexamic acid 100 mg/kg/h infusion, Saline solution
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- The Hospital for Sick Children
Hemorrhage
Predictions of Bleeding During Liver Transplantation With Thromboelastometry
Patients with cirrhosis present complex coagulation defects. Conventional coagulation tests (INR, platelets count) can not predict bleeding or blood product requirements during liver transplantation.
- Trial name
- NCT02356068
- Testing
- ROTEM analysis
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
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