Clinical trials: Transfusions
Atrial Fibrillation
The Influence of Preoperative Warfarin Medication on Thromboelastography and Blood Transfusion
Warfarin therapy is usually monitored using the international normalized ratio (INR), and prolonged INR means coagulation impairment that can leads elevating transfusion requirement after operation.
- Trial name
- NCT02191449
- Where
- South Korea
- Volunteers
- 107 people
- Sponsor
- Konkuk University Medical Center
Post-cardiac Surgery, Blood Transfusion Complication
Perioperative Risk Factors of Outcomes for Cardiac Surgery: A Retrospective Study
Based on a review of about 10,000 patients undergoing cardiac surgery under CPB in West China Hospital of Sichuan University and the Second Affiliated Hospital of Zhejiang University, we try to evalute the effect of blood…
- Conditions
- Post-cardiac Surgery, Blood Transfusion Complication, Prognosis
- Trial name
- NCT04980742
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Severe Anemia
Outcomes of Patient Blood Management in Severely Anemic Patients
The goal of this observational cohort study is to compare patients with very low red blood counts who receive different therapy.
- Trial name
- NCT06345417
- Testing
- Patient Blood Management (PBM), Allogeneic transfusion
- Where
- 2 sites in Germany
- Volunteers
- 20,000 people
- Sponsor
- Helios Klinik Gotha/Ohrdruf
COVID-19
Safety and Efficacy of Convalescent Plasma Transfusion for Patients With COVID-19
This is a multicenter double blinded study to evaluate the efficacy and safety of convalescent plasma from COVID-19 recovered individuals to treat hospitalized patients with severe COVID-19 disease.
- Trial name
- EPCOvid-1 (NCT04388410)
- Testing
- convalescent plasma
- Where
- Mexico
- Volunteers
- 410 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Coagulopathy
Coagulopathy in Acute Aortic Syndrome
The existence of AAS coagulopathy has been reported, related to blood contact with the walls of the non-endothelialized false lumens.
- Trial name
- SAACAOG (NCT05149261)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- European Georges Pompidou Hospital
Very Low Risk, Low Risk, or Intermediate Risk MDS Per IPSS-R
A Study of Etavopivat for the Treatment of Anemia in Patients With Myelodysplastic Syndromes (MDS)
The purpose of this study is to evaluate the safety and efficacy of etavopivat (FT-4202) for the treatment of anemia in adult patients with very low risk, low risk, or intermediate risk MDS.
- Trial name
- NCT05568225
- Testing
- Etavopivat
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 17 people
- Sponsor
- Forma Therapeutics, Inc.
Premature Birth
The Trial of Pessary After Laser for TTTS
Placing a cervical pessary in severe twin-to-twin transfusion syndrome (TTTS) cases treated by fetoscopic laser coagulation (FLC) decreases the spontaneous preterm birth rate.
- Trial name
- PECEPLASER (NCT01334489)
- Testing
- Arabin Cervical Pessary
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 352 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Bleeding, Massive Hemorrhage
Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance
This study is designed to evaluate the effect of early albumin transfusion within massive transfusion protocol on fluid balance and reduced requirement of transfusion.
- Conditions
- Bleeding, Massive Hemorrhage, Massive Transfusion Protocol
- Trial name
- ABSOLUTE (NCT06111261)
- Testing
- Albumin solution, Balanced crystalloid solution
- Volunteers
- 36 people
- Sponsor
- Seoul National University Hospital
Placenta Previa Bleeding
Prediction of Bleeding in Placenta Previa
To assess the ability of clinical and sonographic variables to predict the need of blood transfusion > 4 units of packed RBCS in women undergoing cesarian section for placenta previa .
- Trial name
- NCT05403203
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acceptability of Health Care
Closed-blood Sampling Devices in the Adult Critically Ill Patient
Based on the hypothesis that the strategy of using Closed-Blood Sampling Devices (CSBD, experimental group) compared to the usual practice (waste discard volume, control group), in critically ill adult patients, will decrease the…
- Trial name
- NCT06478160
- Testing
- Closed-Blood Sampling Devices, Waste discard volume
- Where
- 3 sites in Spain
- Volunteers
- 216 people
- Sponsor
- University of Barcelona
Traumatic Brain Injury
Age of Blood in Brain Injury
Donated red blood cells vary in how old they are, that is, how long they have been stored since being collected from donors. Blood that has been donated is stored for a maximum of 42 days, after this time it is expired.
- Trial name
- NCT00141674
- Testing
- Blood Transfusion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
PRBC Transfusion, CABGs
Packed Red Blood Cell Transfusion in Elective Coronary Artery Bypass Graft Surgery in A University Hospital
In Siriraj Hospital, blood consumption in Cardiac surgery is high (units per patient) and frequent (number of patients receiving blood).
- Trial name
- NCT02585310
- Testing
- Packed red blood cell transfusion
- Volunteers
- 300 people
- Sponsor
- Mahidol University
Spinal Disorders, Degenerative Spine Disease
Dose-Dependent Effects of Intraoperative Tranexamic Acid on Surgical Bleeding and Transfusion Requirements in Multilevel Thoracolumbar Spinal Surgery
Multilevel spinal stabilization surgery is frequently associated with substantial blood loss and increased transfusion requirements.
- Conditions
- Spinal Disorders, Degenerative Spine Disease, Blood Loss, Surgical
- Trial name
- NCT07288697
- Testing
- low-dose TXA, high-dose TXA
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Blood Donors, Acquired Immunodeficiency Syndrome
KSHV Infection in Blood Donors From Texas
To determine the seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) in blood donors from Texas. Also to examine the donors' demographic characteristics and to characterize the KSHV using polymerase chain…
- Conditions
- Blood Donors, Acquired Immunodeficiency Syndrome, Blood Transfusion, Herpesvirus, Kaposi Sarcoma-Associated
- Trial name
- NCT00006310
- Sponsor
- The University of Texas Health Science Center at San Antonio
Blood Donation, Blood Transfusion
Donor Lifestyle and Nutritional Status, Blood Component Quality, and Patient Safety (ESENCIA)
The goal of this observational study is to evaluate how blood donors' lifestyle and nutritional status influence the quality of packed red blood cells (pRBCs) during storage and their impact on patient safety in transfused…
- Trial name
- ESENCIA (NCT07558369)
- Where
- Mexico
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Perinatologia
Cardiovascular Disease
Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
To evaluate the efficacy of Hemolink™ in combination with Intraoperative Autologous Donation (IAD) versus control (IAD alone) in facilitating avoidance of allogeneic RBC transfusion during and following primary CABG surgery
- Trial name
- NCT00038454
- Testing
- Hemolink (hemoglobin raffimer IV solution)
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Hemosol
Trauma/Injury Problem
Early Whole Blood in Patients Requiring Transfusion After Major Trauma
The proposal will assess if patients who require massive transfusion can be accurately predicted early after emergency department arrival and assess if the use of stored whole blood during initial resuscitation will reduce…
- Trial name
- NCT01227005
- Testing
- Transfusion of blood products
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- The University of Texas Health Science Center, Houston
Heart Diseases
Hemoderivative Imputable Complications in Initial Uncomplicated Heart Surgery
Observational Study of Hemoderivative Transfusion Imputable Complications in Initial Uncomplicated Heart Surgery. Inclusion criteria are patients who discontinued the mechanical ventilation up to 6 hours after exiting operation…
- Trial name
- NCT01457586
- Testing
- Blood transfusion, No blood transfusion
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital Pitangueiras
Anesthesia
The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty
The current study investigates the effect of hypotensive anesthesia on patient hemoglobin levels during primary total knee arthroplasty.
- Trial name
- NCT05340751
- Testing
- Blood drawn
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hospital for Special Surgery, New York
Sickle Cell Disease
Hydroxyurea and Transfusion
This study will prospectively investigate the feasibility, safety, and transfusion requirements of adding hydroxyurea to simple chronic transfusions for patients with sickle cell anemia already on chronic transfusions.
- Trial name
- HAT (NCT03644953)
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Children's National Research Institute
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