Clinical trials: Transfusions
Anemia, Blood Loss, Surgical
An Observational Study of Blood Management Techniques in Oncology Surgical Treatment
The purpose of this study is to observe the methods used to manage blood loss in surgical procedures to remove tumors from patients with cancer and to determine if there is a relationship with the need for blood transfusions.
- Conditions
- Anemia, Blood Loss, Surgical, Neoplasms
- Trial name
- NCT00264095
- Testing
- Oncological surgery
- Where
- 11 sites in Netherlands
- Volunteers
- 488 people
- Sponsor
- Janssen-Cilag B.V.
Disorder, Heart
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on…
- Conditions
- Disorder, Heart, Postoperative, Cardiac Surgery
- Trial name
- TRICS-IV (NCT04754022)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 54 sites in United States, Australia and 14 more
- Volunteers
- 1,440 people
- Sponsor
- Unity Health Toronto
Clinical Safety of a PBM Program
The German Patient Blood Management Network
This epidemiological trial will determine whether the implementation of a PBM program is safe and effective in terms of clinical outcome compared to a pre-implementation cohort Primary endpoint is a composite outcome comprising…
- Trial name
- NCT02147795
- Where
- 2 sites in Germany
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Postoperative; Dysfunction Following Cardiac Surgery, Transfusion Related Complication
Impact of RBC Transfusion Less Than 14 Days on Morbidity and Mortality in Cardiac Surgical Patients
The purpose of the transfusion of packed red blood cell is to overcome acute or chronic anemia cause tissue hypoxia. It increases hemoglobin concentration and consequently increase oxygen delivery to peripheral tissues.
- Trial name
- CGRCard (NCT01915654)
- Testing
- study population
- Where
- France
- Volunteers
- 459 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Trauma
The Effect of Red Blood Cells Transfusion in Trauma Patients
We will evaluate the effect of red blood cell (RBC) transfusion on fatal and non fatal events according to baseline risk of death in an international cohort of trauma patients (CRASH-2 trial).
- Trial name
- NCT01746953
- Volunteers
- 20,211 people
- Sponsor
- Progress
Non-transfusion-dependent Thalassemia, Low Risk Myelodysplastic Syndrome
Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124
The primary purpose of this study is to determine the safety and tolerability of SLN124 for the treatment of non-transfusion-dependent (NTD) β-thalassaemia and low risk myelodysplastic syndrome.
- Trial name
- NCT04176653
- Where
- 5 sites in Bulgaria, United Kingdom
- Sponsor
- Silence Therapeutics plc
Prematurity Complications, Anemia
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood
Long-term morbidities among very low birth weight infants remain a significant challenge. Oxidative stress is a key factor in the pathogenesis of 'free radical (FR) diseases of prematurity,' including retinopathy of prematurity…
- Trial name
- ANH-Prestige (NCT07636473)
- Testing
- Cord Blood Red Blood Cell Transfusion (CB-RBC), Adult Donor Red Blood Cell Transfusion (A-RBC)
- Volunteers
- 200 people
- Sponsor
- University of Parma
Transfusion-dependent α-Thalassemia
A Study Evaluating the Safety and Efficacy of the GMCN-508A Drug Product in Transfusion-dependent α-Thalassemia Participants
This is a non-randomized, open label, single-site, single-dose, phase 1 study in up to 5 participants (between 5 and 35 years of age, inclusive) with Transfusion-dependent α-thalassemia.
- Trial name
- NCT05757245
- Testing
- GMCN-508A Drug Product
- Where
- China
- Volunteers
- 5 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Severe Anemia
Cost Analysis of Therapies for Severe Anemia
The goal of this observational study is to learn about the costs that occur when participants with severe anemia are treated with blood transfusions or with patient blood management (PBM).
- Trial name
- NCT06345469
- Testing
- Patient blood management (PBM), Allogeneic transfusion
- Volunteers
- 640 people
- Sponsor
- Helios Klinik Gotha/Ohrdruf
Thalassemia in Children
Benson's Relaxation Technique, Music Therapy for Children With Thalassemia
The aim of the present study is to determine the effect of Benson's relaxation technique versus music therapy on physiological parameters and stress of children with thalassemia during blood transfusion.
- Trial name
- NCT05730374
- Testing
- Benson's Relaxation technique, Music therapy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Neoplasms, Thrombocytopenia
Safety and Efficacy of (PN-152,243)/PN-196,444 in the Prevention of Thrombocytopenia
Intensive chemotherapy is associated with significant thrombocytopenia, often requiring platelet transfusion to maintain platelet counts. This investigational drug has demonstrated the ability to increase platelet counts.
- Conditions
- Neoplasms, Thrombocytopenia, Multiple Myeloma, Lymphoma, Malignant
- Trial name
- NCT00037791
- Testing
- (PN-152,243)/PN-196,444
- Where
- 9 sites in United States, Argentina and 1 more
- Volunteers
- 180 people
- Sponsor
- Pfizer
Blood Transfusion
Blood Sparing Strategies: Single Shot High Dose Erythropoietin Two Days Before Heart Surgery
All patients operated on at the European Hospital Heart surgery Division will be randomized to either single dose 80.000 UI of Human Recombinant Erythropoietin and intravenous iron or control.
- Trial name
- SHOT (NCT01265680)
- Testing
- Erythropoietin
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Cardiochirurgia E.H.
Preterm Infants
Randomized Study of Weekly Erythropoietin Dosing in Preterm Infants
Preterm infants are a risk for multiple transfusions, and the administration of human recombinant erythropoietin (Epo) has been shown to decrease transfusion requirements.
- Trial name
- NCT01235923
- Testing
- three times weekly Epo, weekly Epo
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of New Mexico
Hematologic Diseases
Clinical Study of Combined Platelet Transfusion
Platelet transfusion is an irreplaceable and important treatment method for clinical prevention and treatment of thrombocytopenia or platelet dysfunction.
- Trial name
- NCT06613425
- Testing
- Combined platelets
- Where
- China
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- The General Hospital of Western Theater Command
Cesarean Section, Infant Conditions
Intact-cord Stabilisation and Physiology-based Cord Clamping in Caesarean Sections
This is a feasibility study with historical control designed to evaluate whether delivery of the placenta prior to umbilical cord clamping at caesarean sections is a feasible, safe and acceptable way of facilitating intact-cord…
- Trial name
- INTACT (NCT05461950)
- Testing
- Extrauterine placental transfusion and physiology-based umbilical cord clamping, Extrauterine placental transfusion, intact cord stabilisation and physiology-based umbilical cord clamping, Delayed umbilical cord clamping
- Where
- Norway
- Volunteers
- 263 people
- Sponsor
- Helse Møre og Romsdal HF
Anemia, Post ICU Syndrome
Iron Deficiency at ICU Discharge
IRON-RECOVERY is a prospective, multicenter, observational cohort study designed to determine the prevalence of iron deficiency at intensive care unit (ICU) discharge and to evaluate its association with post-ICU clinical…
- Conditions
- Anemia, Post ICU Syndrome, Red Blood Cell Transfusions, Iron Deficiencies
- Trial name
- IRON-ICU (NCT07781540)
- Testing
- transferrin saturation
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 462 people
- Sponsor
- Università degli Studi di Ferrara
Blood Loss, Surgical, Postoperative Hemorrhage
Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy
The purpose of this study is to assess if aprotinin (BAYA0128), given intravenously during your surgery, is safe and can help reduce the need for a blood transfusion during bladder surgery.
- Trial name
- NCT00306150
- Testing
- Trasylol (Aprotinin, BAYA0128)
- Where
- 37 sites in United States, Belgium and 5 more
- Volunteers
- 57 people
- Sponsor
- Bayer
Infection After Transfusion
The Immunomodulation Effect of Blood Transfusion in Operative Spine Surgery Patients
The purpose of this study is to investigate the effect of transfusion of allogeneic (homologous) red cells on the immunologic parameters such as T-cells as well as natural killer cell count/function, various interleukins, TNF…
- Trial name
- NCT02069210
- Testing
- Blood transfusion
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Liver Transplantation
Effect of Rapid Transfusion With Fluid Management System 2000® (FMS)
Rapid infusion of red blood cells is known to result in the increase of plasma potassium. The researchers are trying to investigate the change in plasma potassium during rapid infusion of mixed blood components in the reservoir…
- Trial name
- FMS (NCT01448343)
- Testing
- Fluid management system 2000 (FMS)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Non-idiopathic Scoliosis
Non-Idiopathic Scoliosis Treated With Tranexamic Acid
Investigation of tranexamic acid (TXA) for reducing perioperative blood loss and transfusion requirement in pediatric patients with secondary scoliosis undergoing posterior spinal fusion.
- Trial name
- NCT01089140
- Testing
- Tranexamic acid 10mg/kg/hr, Tranexamic acid 100 mg/kg/h infusion, Saline solution
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- The Hospital for Sick Children
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