Clinical trials: Transfusions
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Leukemia
Eculizumab in Treating Patients With Paroxysmal Nocturnal Hemoglobinuria
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of eculizumab may prevent leukemia and stop the destruction of red blood cells in patients with paroxysmal…
- Trial name
- NCT00112983
- Testing
- eculizumab
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Anemia (Diagnosis), Iron-deficiency
Transfusion Rates in Total Hip Replacement Before/After the Implementation of a Patient Blood Management Program.
Retrospective observational study: impact of a peri-operative patient blood management program (PBM) on transfusion rates of patients undergoing elective hip replacement.
- Conditions
- Anemia (Diagnosis), Iron-deficiency, Transfusion, Arthroplasty
- Trial name
- pbm-hip (NCT04398238)
- Testing
- evaluation by transfusion medicine specialist
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Ortopedico Rizzoli
Hemorrhage
Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage
CRASH 2 is a large pragmatic randomised placebo controlled trial of the effects of the early administration of the antifibrinolytic agent tranexamic acid on death, vascular events and transfusion requirements.
- Trial name
- NCT00375258
- Testing
- Tranexamic acid, Sodium Chloride 0.9%
- Where
- United Kingdom
- Volunteers
- 20,211 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Thalassemia Major
NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major
The effect of N_acetylcystein as an antioxidant on iron overload and frequency of blood transfusion in β-thalassemia major patients at Assiut Childern Hospital University And its cosubmitted for partial fulfillment of master…
- Trial name
- NCT05777733
- Testing
- n-acetylcystine
- Volunteers
- 100 people
- Sponsor
- Assiut University
Iron Overload
Safety and Efficacy of Ferriprox™ (Deferiprone) Oral Solution in Iron Overloaded Pediatric Patients
The primary objective is to assess the safety of Ferriprox oral solution for the treatment of iron overload in pediatric patients with transfusion-dependent anemia.
- Trial name
- NCT00529152
- Testing
- Deferiprone
- Where
- 4 sites in Egypt, Indonesia and 1 more
- Volunteers
- 100 people
- Sponsor
- ApoPharma
COVID-19
Safety in Convalescent Plasma Transfusion to COVID-19
There is currently no specific vaccine or treatment to treat critically ill patients with COVID-19. Different therapies are still under investigation and are use in different health institutions, however, a significant proportion…
- Trial name
- NCT04333355
- Testing
- Convalescent Plasma
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- TecSalud Investigación Clínica
Hemorrhage, Cancer Surgery
AutoTransfusion Versus TRAnsfusion in Cancer Surgery
Acute bleeding is one of the most frequent intraoperative adverse events and is burdened with a significant morbidity and mortality rate.
- Conditions
- Hemorrhage, Cancer Surgery, Transfusion
- Trial name
- ATTRACS (NCT05452538)
- Testing
- Transfusion
- Where
- France
- Volunteers
- 5,808 people
- Sponsor
- Centre Leon Berard
Blood Coagulation Disorders, Trauma
Evaluating URMC's Massive Transfusion Protocol
The purpose of the study is to evaluate the efficacy of the University of Rochester Medical Center's current Massive Transfusion Protocol.
- Conditions
- Blood Coagulation Disorders, Trauma, Acute Coagulopathy
- Trial name
- MTP-TEG (NCT02083549)
- Testing
- Blood collection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Rochester
Transfusion Related Complication
Transfusion Strategy in Hematological Intensive Care Unit
Patients with acute hematological disease (acute leukemia, aplastic anemia, hematopoietic stem cells autologous or allogeneic ...) and hospitalized in an intensive care unit hematology require compensation of anemia and…
- Trial name
- 1VERSUS2CGR (NCT02461264)
- Testing
- Single red blood packed cells Transfusion, Two packed red blood cells Transfusion
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Caen
Erythroblastosis, Fetal, Erythroblastosis Fetalis, Rh Disease
EPO-4-Rhesus Study
Up to 80% of infants with hemolytic disease due to maternal alloimmunization, treated with IUT, require at least one top-up transfusion for late anemia during the first 3 months of life.
- Conditions
- Erythroblastosis, Fetal, Erythroblastosis Fetalis, Rh Disease, Erythroblastosis Fetalis Due to RH Antibodies, Erythroblastosis Fetalis Due to Isoimmunization
- Trial name
- EPO-4-Rhesus (NCT03104426)
- Testing
- Darbepoetin Alfa
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Cardiac Surgery Under Extra Corporeal Circulation, Cardiac Surgery Requiring Cardiopulmonary Bypass
Comparison of the Performance and Effectiveness of Two Transfusion-Saving Devices: Cell-Saver and SAME
An observational study comparing two systems of perioperative blood recovery in cardiac surgery, one system allowing red blood cell reinfusion and one system allowing red blood cell and platelet reinfusion.
- Trial name
- SAME-CELL (NCT06766032)
- Testing
- CELL-Saver, SAME
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Nantes University Hospital
Twin to Twin Transfusion as Antepartum Condition, Monochorionic Diamniotic Placenta
Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome
The purpose of this study is to evaluate the use of diode laser photocoagulation of the communicating vessels in twin-to- twin transfusion syndrome (TTTS) with respect to maternal, fetal and neonatal outcomes.
- Trial name
- NCT05008744
- Testing
- Fetoscopic laser ablation
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital
VV ECMO, Bleeding
Incidence of Bleeding, Thrombosis and Transfusion Requirements in ICU Patients With COVID-19 Supported With Veno-venous Extracorporeal Membrane Oxygenation
The investigators aim to assess the risk of bleeding and thrombo-embolic complications as well as benefit and harm of blood product transfusion and anticoagulation therapy in adult ICU patients with COVID-19 supported with V-V…
- Conditions
- VV ECMO, Bleeding, Thrombosis, Transfusion Adverse Reaction
- Trial name
- NCT07352072
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Arthroplasty, Hip
Liberal Versus Restrictive Transfusion During Symptomatic Moderate Anemia After Hip Arthroplasty
The purpose of this study is to evaluate the effects of transfusion of red blood cells in treating postoperative dizziness in patients with moderate postoperative anemia after total hip arthroplasty.
- Trial name
- NCT01452581
- Testing
- Red blood cell transfusion, Voluven
- Where
- 2 sites in Denmark
- Volunteers
- 5 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiac Surgery, Cardiopulmonary Bypass
Restrictive Transfusion StratEgy Adjusted by SvO2 During Cardiac Surgery
The goal of the clinical trial is to evaluate whether a restrictive transfusion strategy adjusted by SvO2 during the perioperative period of cardiac surgery may reduce the incidence of red blood cell transfusion.
- Trial name
- RETSEACSII (NCT05740059)
- Testing
- Adjusted Transfusion
- Where
- France
- Volunteers
- 676 people
- Sponsor
- University Hospital, Montpellier
Myelodysplastic Syndromes, Transfusion-dependent Anemia
Impact of 2 Transfusion Strategies on Quality of Life of Multitransfused Patients With Low-risk Myelodysplastic Syndrome
Myelodysplastic syndromes (MDS) are heterogeneous malignant bone marrow disorders characterized by ineffective haematopoiesis, peripheral blood cytopenias and variable risk of leukaemia transformation.
- Trial name
- SMD-transfu (NCT03643042)
- Testing
- Transfusion
- Where
- 19 sites in France
- Volunteers
- 11 people
- Sponsor
- Lille Catholic University
Transfusion Related Complications
Clinic Trial for West China Perioperative Transfusion Score (WCPTS)
Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the…
- Trial name
- WCPTS (NCT01597232)
- Testing
- Transfusion trigger based on WCPTS, Maintenance of hemoglobin level more than 10g/dL, Transfusion trigger based on experience
- Where
- China
- Volunteers
- 1,351 people
- Sponsor
- West China Hospital
Thrombocytopenia, Transfusion
Study Comparing Platelet Transfusion Volumes in Premature Babies
Platelet transfusions can help clotting but may also have risks. Currently when babies get platelet transfusions they get as much as three times (per kilogram of body weight) as much as adults do.
- Trial name
- PlaNeT-3 (NCT06095648)
- Testing
- Dose of platelet transfusion
- Where
- Ireland
- Volunteers
- 370 people
- Sponsor
- University College Dublin
Thrombocytopenia, Neonatal
Neonatal Platelet Transfusion Threshold Trial
The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without…
- Conditions
- Thrombocytopenia, Neonatal, Platelet Transfusion, Infant, Newborn, Diseases
- Trial name
- NeoPlaTT (NCT06676904)
- Testing
- Higher Platelet Transfusion Threshold, Lower Platelet Transfusion Threshold
- Where
- 20 sites in United States
- Volunteers
- 2,433 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
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