Clinical trials: Transfusions
Hemorrhage, Valvular Heart Surgery
Dose-ranging Study of Tranexamic Acid in Valve Surgery
Cardiac surgical procedures account for a large amount of allogeneic transfusion. Tranexamic acid (TA), a synthetic antifibrinolytic drug, has been shown to reduce blood loss and transfusion requirements in cardiac surgery with…
- Trial name
- NCT01191554
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hip Fractures Pathologic, Anemia
HiFIT Study : Hip Fracture: Iron and Tranexamic Acid
Fractures of the upper end of the femur, called commonly "Hip fractures" are very common, with an incidence of approximately 1.6 million cases per year worldwide.
- Trial name
- HiFIT (NCT02972294)
- Testing
- Iron Isomaltoside 1000, Tranexamic Acid
- Where
- 13 sites in France
- Volunteers
- 419 people
- Sponsor
- University Hospital, Angers
Bleeding, Central Line Complication
Bleeding Events Before vs After Lowering Departmental Platelet Transfusion Trigger
Central venous catheters are essential when administering treatment for hematological conditions. Many patients have a decreased platelet count which increases the risk for bleeding complications. Baarle et al.
- Conditions
- Bleeding, Central Line Complication, Thrombocytopenia, Hematologic Diseases
- Trial name
- OBS-PLATE (NCT06187831)
- Where
- Sweden
- Volunteers
- 927 people
- Sponsor
- Thomas Kander
Oncologic Disorders, Hematologic Diseases
Clinical Use of Pathogen Reduced Red Blood Cell Suspension
The aim of the study is to evaluate the effectiveness and safety of the application of pathogen inactivated RBC suspension in children with oncological and hematological diseases.
- Trial name
- NCT03426553
- Testing
- Riboflavin+UV RBC, irradiated RBC
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Iron Deficiency, Anemia
Effect of Infant Placement on Iron Stores in Infancy: A Pilot Study
This is a pilot study designed to assess the safety of placing an infant on the mother's abdomen at the time of delivery, prior to clamping the umbilical cord and the effect of placing the infant on the mother's abdomen on the…
- Trial name
- NCT00675337
- Testing
- perineum maintained, abdominal placement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Davison, James, D.O.
Healthy, Transfusion Reactions
Effects of Antibodies to White Blood Cells on Platelet Transfusion Patients
This study will determine if transfusion of platelets containing HLA antibodies (certain antibodies to white blood cells) are more likely to cause transfusion reactions than transfusion of platelets that do not contain HLA…
- Trial name
- NCT00460122
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Thalassemia, Iron Overload
Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded Patients
The safety and efficacy of CN128 is studied in thalassaemia with sever liver iron overloaded patients.
- Trial name
- NCT05355766
- Testing
- CN128 Tablets
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Hangzhou Zede Pharma-Tech Co., Ltd.
Hemolysis
R-FACT Study:Risk Factors for Alloimmunization After Red Blood Cell Transfusions
Alloantibodies can lead to serious clinical consequences and logistic problems like obtaining properly and timely matched blood for the patients who do develop these antibodies.
- Trial name
- R-FACT (NCT01616329)
- Where
- Netherlands
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Liver Cirrhosis, Coagulopathy
Prevention of Bleeding in Patient With Cirrhosis Undergoing Dental Extraction
The purpose of this study is to investigate how effective and cost saving 1-deamino-8-D-arginine vasopressin (desmopressin, DDAVP) is as opposed to the transfusion of blood products in preventing bleeding after teeth extraction…
- Trial name
- NCT00816127
- Testing
- Desmopressin, blood transfusion
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anemia, Sickle Cell, Transfusion Hemosiderosis
Clinical Importance of Treating Iron Overload in Sickle Cell Disease
Hypothesis: The investigators suspect that significant degrees of iron overload in subjects with SCD result in decreased red cell survival, abnormal endothelial function and markedly dysregulated autonomic function.
- Trial name
- NCT00981370
- Testing
- deferasirox
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Los Angeles
Transfusion
Use of Cell Salvage Post-operatively in Infants to Decrease Use of Allogeneic Blood Product Transfusions
Transfusion of washed intra-operative cell salvage post-operatively in the PCICU can be performed safely without increased risk of bleeding or release of inflammatory mediators.
- Trial name
- cell salvage (NCT01211366)
- Testing
- Cell Saver RBCs, Conventional volume infusion
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Rochester
Prostatic Neoplasms, Anemia
Effect of Darbepoetin Alfa (Aranesp®) on Anemia in Patients With Advanced Hormone Independent Prostate Cancer
The purpose of this study is to determine whether or not Aranesp® (Darbepoetin Alfa), administered every fourth week, is effective in the treatment of blood shortage (anemia) compared to standard care of treatment (blood…
- Trial name
- NCT00381836
- Testing
- Darbepoetin Alfa
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus
Healthy
Feasibility Study of Mirasol-Treated Whole Blood Red Cell Recovery and Survival
Feasibility trial to evaluate recovery and survival of red blood cells (RBCs) from Mirasol-treated whole blood
- Trial name
- IMPROVE (NCT00742001)
- Testing
- Mirasol System for Whole Blood.
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio
Transfusion Reactions
Mild Pulmonary Function Changes With Transfusion
The purpose of the study is to determine whether transfusion is associated with mild pulmonary changes.
- Trial name
- NCT00681954
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of California, San Francisco
Hip Fractures, Intertrochanteric Fractures
Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement
Intertrochanteric hip fractures typically result in blood loss from the fracture and require surgery that can cause further blood loss.
- Trial name
- NCT03182751
- Testing
- Tranexamic Acid (TXA)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Mayo Clinic
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Affecting Blood Constituents
Antibiotic Concentrations After MassivE Transfusion Study
Combat and civilian trauma frequently result in open wounds that are at risk for infection. Data from the Department of Defense Trauma Registry demonstrate that 74% of combat trauma casualties have an open wound.
- Trial name
- ACME (NCT06699901)
- Testing
- Massive Transfusion Group, Control Group
- Where
- 2 sites in United States
- Volunteers
- 417 people
- Sponsor
- Brooke Army Medical Center
Myocardial Injury, Acuter Kidney Injury
Impact of Perioperative Allogeneic Red Blood Cell Transfusion on Postoperative Myocardial Injury After Liver Resection
We aimed to explore the influence of ABT on the incidence of MINS, AKI, and overall prognosis among advanced-age HCC patients who underwent hepatectomy
- Trial name
- NCT07125612
- Volunteers
- 487 people
- Sponsor
- Hao Li
Cardiovascular Diseases
Use of the Quantra QPlus Sytem in Cardiac Surgery
Single center retrospective study evaluating the impact of using the Quantra QPlus System to guide transfusion decisions on postoperative outcomes in patients undergoing cardiac surgery.
- Trial name
- NCT05501730
- Testing
- Quantra QPlus System
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- HemoSonics LLC
Hemolytic Disease of the Newborn, Fetal Anemia
Neonatal Outcomes on Direct Fetal Intravenous Immunoglobulin During Intrauterine Transfusion for Rhesus Isoimmunization
The goal of this clinical trial is to learn if giving intravenous immunoglobulin directly to the fetus during intrauterine transfusion can improve newborn outcomes in pregnancies affected by rhesus isoimmunization.
- Conditions
- Hemolytic Disease of the Newborn, Fetal Anemia, Rhesus Isoimmunization, Erythroblastosis Fetalis Due to RH Antibodies
- Trial name
- NCT07885592
- Testing
- Intrauterine Transfusion, Intravenous immunoglobulin (IVIG)
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Anemia
A Phase 1 Safety Study of SANGUINATE™ In Patients With Acute Severe Anemia.
In this open-label study, eligible and consenting adult patients admitted to the hospital for critical care that have acute severe anemia, defined as a blood hemoglobin level ≤ 5 g/dL, but who are unwilling or unable to receive…
- Trial name
- NCT02754999
- Testing
- SANGUINATE™
- Where
- 32 sites in United States
- Volunteers
- 103 people
- Sponsor
- Prolong Pharmaceuticals
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