Clinical trials: Transgender
Patient Satisfaction, Surgical Wound
Sub vs Trans-umbilical Incision: A Patient's Satisfaction-centered Trial
While some studies have suggested that subumbilical and transumbilical incisions have a similar clinical efficiency and safety, no study has yet evaluated their respective impact on patient's postoperative aesthetic satisfaction.
- Conditions
- Patient Satisfaction, Surgical Wound, Incision, General Surgery
- Trial name
- NCT03026400
- Testing
- Transumbilical incision, Subumbilical incision
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Pre-Exposure Prophylaxis of HIV Infection
Pre-Exposure Prophylaxis Study of Lenacapavir in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People at Risk for HIV Infection
The goal of this study is to evaluate the efficacy of the study drugs, lenacapavir (LEN) in preventing HIV infection, in participants ≥ 16 years of age who have condomless receptive anal sex with partners assigned male at birth…
- Trial name
- PURPOSE 2 (NCT04925752)
- Testing
- Oral Lenacapavir (LEN), F/TDF, Sub-cutaneous (SC) Lenacapavir (LEN)
- Where
- 93 sites in United States, Argentina and 6 more
- Volunteers
- 3,292 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Gender Dysphoria
Comparison of PKs of 17-Beta-Estradiol Via Sublingual Placement Versus Swallowing in Male-to-Female Transgender Patients
This crossover study will investigate the pharmacokinetics of oral versus sublingual administration of 17-beta-estradiol in the trans-female population.
- Trial name
- NCT05428215
- Testing
- 17beta Estradiol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Metabolic Syndrome, Abdominal Obesity
Copenhagen Obesity Risk Assessment Study
The aim of the present study is to assess the effect of a high intake of industrially produced trans fatty acids for 16 weeks on abdominal obesity and risk markers of type 2 diabetes and heart disease in healthy, moderately…
- Conditions
- Metabolic Syndrome, Abdominal Obesity, Heart Disease, Type 2 Diabetes
- Trial name
- COBRA (NCT00655902)
- Testing
- Trans fat (soy bean oil), Control fat (sunflower oil)
- Where
- Denmark
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Migraine Disorders
Transnasal Therapy for Acute Migraine Attack
Migraine is a significant health problem in the United States with 34 million Americans suffering from migraine attacks every year. High-flow oxygen has been successfully used in several clinical studies.
- Trial name
- NCT04129567
- Testing
- Humidified oxygen, Dry oxygen, Humidified air
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Post Operative Analgesia, Opioid Sparing Anaesthesia
To Compare Post-op Analgesic Effectiveness of Ropivicaine+Dexamethasone and Ropivacane+Dexmetomidine in TAP Block in Stoma Reversal Under GA in Terms of Duration of Analgesia.
Controlling pain is of major concern in intra-operative as well as post-operative period inpatients undergoing all surgeries especially abdominal surgeries.Adequate pain control in post-operative period directly effect patient's…
- Conditions
- Post Operative Analgesia, Opioid Sparing Anaesthesia, Hypotension, Controlled, Bradycardia
- Trial name
- NCT07368075
- Testing
- TAP Block with Ropivacaine+Dexamethasone, TAP Block with Ropivacaine+Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Gender Dysphoria
Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans
Transgender Veterans (trans Vets) frequently experience gender dysphoria or distress related to discord between their gender identity and birth sex.
- Trial name
- NCT06615401
- Where
- United States
- Volunteers
- 986 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Human Immunodeficiency Virus, Sexually Transmitted Diseases
A Non-inferiority Randomized Controlled Trial to Evaluate Promoting Condom Use Among MSM and Transgender Individuals in China
This is a pragmatic, non-inferiority, randomized controlled trial comparing the effectiveness of two methods (crowdsourcing versus social marketing) for creating one-minute videos promoting condom use among MSM and TG in China.
- Trial name
- NCT02516930
- Testing
- crowdsourced video, social marketing video
- Where
- China
- Volunteers
- 1,173 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Myopia
Corneal WFG Versus AF Trans PRK in Myopic Patients With High Corneal HOA
compare the efficacy, safety and predictability of corneal wavefront guided (WFG) and aberration free ablation in single-step transepithelial photorefractive keratectomy (TransPRK) in myopic patients with high pre-existing…
- Trial name
- NCT03786861
- Testing
- corneal WFG group, aberration free group
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Distress, Emotional
Expressive Writing Intervention Study
This study aims to test to what extent an expressive writing intervention may reduce internalized anti-TNB (trans and nonbinary) stigma and promote well-being over time.
- Trial name
- NCT05782868
- Testing
- Expressive writing in response to vignette, Expressive writing about events of the day, Letter of Gratitude
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Human Immunodeficiency Virus (HIV) Infections
A Study of Islatravir (MK-8591) in Trans and Gender Diverse Participants (MK-8591-035)
The primary objective of this study is to evaluate the safety and tolerability of Islatravir (ISL) in trans and gender diverse (TGD) participants who are receiving gender-affirming hormone therapy (GAHT) and are at low-risk for…
- Trial name
- NCT05130086
- Testing
- Islatravir
- Volunteers
- healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Prostate CA
Trans and Non-binary Prostate-Specific Antigen Reference Interval Determination Study
The prostate specific antigen (PSA) blood test can help diagnose prostate problems, including cancer. The prostate is an organ in the pelvis. It is found in cisgender men, transgender (trans) women and some non-binary people.
- Trial name
- TransPRIDE (NCT06987045)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Obesity, Insulin Resistance
Resveratrol and the Metabolic Syndrome
Metabolic syndrome is a serious health condition that affects about 35 percent of adults and places them at higher risk of cardiovascular disease, diabetes, stroke and diseases related to fatty buildups in artery walls.
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT01714102
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
HIV Infections, Sexually Transmitted Diseases
Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment
The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Stigma, Social
- Trial name
- NCT03678181
- Testing
- Information Resources, Social Support, HIV Testing
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Gender Dysphoria
The Strategic Use of Hyaluronic Acid Fillers and Neurotoxin to Influence Gender Perception in Transgender Individuals
Observational survey study of transgender individuals who have undergone cosmetic neurotoxin and soft tissue filler for the purpose of influencing gender perception.
- Trial name
- NCT04478214
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mountain Dermatology Specialists
Glaucoma
Comparing Conscious Sedation to Retrobulbar Block Anesthetics During Trans-scleral Diode Laser
This is a non-inferiority trial with a prospective randomized controlled design assessing patient satisfaction and complications associated with both retrobulbar block anesthetics (current gold standard) and conscious IV sedation…
- Trial name
- NCT03646500
- Testing
- Retrobulbar Block, Remifentanil
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Queen's University
HIV Infections, HIV Primary Infection
A Couples-based Intervention for Transgender Women and Their Partners
This project seeks to test the efficacy of a couples-based HIV prevention program in large-scale randomized controlled trial (RCT) to reduce HIV risk among transgender woman and their partners.
- Trial name
- T2 (NCT04067661)
- Testing
- CHIP, Control
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cognitive Performance, Mood
Cognitive Effects of 500mg Trans-resveratrol
This study investigated the potentially cognitive enhancing effects of 500mg trans-resveratrol in healthy, young humans.
- Trial name
- NCT01794351
- Testing
- Trans-resveratrol
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Contact With or Exposure to Human Immunodeficiency Virus
ImPrEP LEN Brasil: Twice-Yearly Lenacapavir for HIV Prevention
The goal of this study is to learn how well long-acting lenacapavir works to prevent human immunodeficiency virus (HIV) infection in people at higher risk of getting HIV in Brazil.
- Trial name
- ImPrEP LEN (NCT07497594)
- Testing
- Lenacapavir long-acting, Tenofovi-Emtricitabine (TDF/FTC) tablet
- Where
- 8 sites in Brazil
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
HIV Infections
The Implementation of Pre-exposure Prophylaxis of Injectable Cabotegravir
Although CAB LA PrEP has been proven efficacious in blinded randomized controlled clinical trials, additional research is needed to evaluate effectiveness in real world settings as well as to identify effective implementation…
- Trial name
- ImPrepCab (NCT05515770)
- Testing
- Cabotegravir Injection
- Where
- Brazil
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Evandro Chagas National Institute of Infectious Disease