Clinical trials: Transient Neurologic Syndrome
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Biomarkers in Neurodegenerative Diseases
The general purpose of this observational study is to examine biomarkers associated with the pathology of neurodegenerative diseases to potentially develop novel therapeutic approaches.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer Disease (AD), Dementia With Lewy Bodies (DLB), Frontotemporal Lobar Degeneration (FTLD)
- Trial name
- NCT04055532
- Testing
- Neuraceq
- Where
- United States
- Sponsor
- University of Minnesota
Primary Central Nervous System Lymphoma
A Prospective Clinical Study of BTK Inhibitor, PD-1 and Formustine in the First-line Treatment of Primary Central Nervous System Lymphoma
To observe the efficacy and safety of a new generation of BTK inhibitor Orelabrutinib combined with PD-1 and fotemustine in the treatment of patients with primary central nervous system lymphoma (PCNSL).
- Trial name
- NCT04831658
- Testing
- the dose-escalation phase
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Mingzhi Zhang
Silver Russell Syndrome, Beckwith-Wiedemann Syndrome
IDMet (RaDiCo Cohort) (RaDiCo-IDMet)
The goal of this observational study is to describe the natural history of imprinting disorders (IDs) according to their metabolic profile in all patients (adults and children) affected with an ID regardless of the severity of…
- Conditions
- Silver Russell Syndrome, Beckwith-Wiedemann Syndrome, Transient Neonatal Diabetes Mellitus, Angelman Syndrome
- Trial name
- IDMet (NCT05945576)
- Where
- 20 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Transient Global Amnesia
PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at…
- Trial name
- PROTOS (NCT06903026)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Diastolic Dysfunction, Neonatal Encephalopathy
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography
The goal of this single-centre longitudinal observational study is to create reference values for diastolic function parameters in neonates born at 35 weeks' gestation or above, and to assess the influence of pre-defined…
- Conditions
- Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
- Trial name
- DiFuSE (NCT06200519)
- Where
- Ireland
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University College Cork
Sleep Apnea Syndromes, Sleep Initiation and Maintenance Disorders
Sleep Deficiency and Stroke Outcome
Deficient sleep duration and sleep disturbances - such as insomnia, sleep disordered breathing (SDB) and restless legs syndrome (RLS)- are associated with hypertension and cardio-cerebrovascular morbidity and mortality.
- Conditions
- Sleep Apnea Syndromes, Sleep Initiation and Maintenance Disorders, Insomnia, Restless Legs Syndrome
- Trial name
- NCT02559739
- Where
- 2 sites in Switzerland
- Volunteers
- 447 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Tourette Syndrome, Tourette's Disorder
Assessment of Children With Tic Onset in the Past 6 Months
The purpose of this research is to study why most children who have tics never develop Tourette syndrome but some do. In other words, we aim to find features that may predict whose tics will go away and whose tics will continue…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor or Vocal Tic Disorder, Transient Tic Disorder
- Trial name
- NewTics (NCT01177774)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Washington University School of Medicine
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
Transient Neurologic Syndrome
Intrathecal Magnesium for Same-day-surgery
5% hyperbaric lidocaine has lost its usefulness for same-day-surgery (SDS) anaesthesia because it has been blamed responsible for the so-called transitory neurological syndrome (TNS).
- Trial name
- MAGLIDIT (NCT01794247)
- Testing
- Magnesium sulfate, Fentanyl, Lidocaine
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Hospital General de Ciudad Real
Cervical Pain, Vasculitis
TransIent Perivascular Inflammation of the Carotid Artery (TIPIC) Syndrome: Clinical and Radiological Follow-up
TIPIC syndrome (previously called carotidynia) is a rare entity of unknown cause, where the patient has a temporary cervical pain associated with a suggestive inflammation around the carotid artery.
- Trial name
- TIPIC-UNV (NCT03804112)
- Testing
- Ultrasound exam with Doppler, Blood samples
- Where
- 6 sites in France
- Volunteers
- 47 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Transient Ischemic Attack, Stroke
Post-stroke Triage "DOC": Simple Screening for Depression, Obstructive Sleep Apnea and Cognitive Impairment
The purpose of this study is to determine whether simple, evidence-based clinical screening be quickly and feasibly implemented (>85% of patients in an average of <6 minutes) in large-volume urgent transient ischemic attack…
- Conditions
- Transient Ischemic Attack, Stroke, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02007265
- Where
- Canada
- Volunteers
- 1,504 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stroke, Transient Ischemic Attack
SLEep APnea Screening Using Mobile Ambulatory Recorders After TIA/Stroke
Obstructive sleep apnea (OSA) is common after stroke/TIA and, left untreated, is associated with recurrent vascular events, poor functional outcomes, and long-term mortality.
- Conditions
- Stroke, Transient Ischemic Attack, Obstructive Sleep Apnea
- Trial name
- SLEAP SMART (NCT02454023)
- Testing
- Portable sleep monitor (ApneaLink Air), In-laboratory polysomnography
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Sunnybrook Health Sciences Centre
Apnea, Sleep Apnea Syndromes
Oropharyngeal Exercises and Post-Stroke Obstructive Sleep Apnea
This study evaluates the feasibility and effectiveness of an oropharyngeal exercise (O-PE) regimen in treating post-stroke obstructive sleep apnea, as an alternative therapy to continuous positive airway pressure (CPAP).
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Stroke
- Trial name
- NCT04212260
- Testing
- Oropharyngeal exercises
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sleep Apnea, Obstructive, Fatty Liver
Prevalence of Non-alcoholic Fatty Liver Disease Among Non-obese Obstructive Sleep Apnea by Using Transient Elastography
Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both common diseases related to metabolic diseases with potential cardiovascular consequences and liver complications respectively.
- Trial name
- NCT05351515
- Where
- Hong Kong
- Volunteers
- 861 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Bradycardia; Syncope, Bradyarrhythmia
Temporary Transvenous Pacemaker Placement by Intracavitary Electrocardiogram Monitoring
Traditional temporary pacing catheter insertion by intracavitary electrocardiogram (IC-ECG) monitoring which only monitoring tip polar, the negative one.
- Conditions
- Bradycardia; Syncope, Bradyarrhythmia, Brady-tachy Syndrome, Tachycardia Bradycardia
- Trial name
- NCT04905199
- Testing
- Temporary transvenous cardiac pacing
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hunan Provincial People's Hospital
Antiphospholipid Syndrome, Ischemic Stroke
Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin as Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE
Antiphospholipid syndrome (APS) has a close association with ischemic stroke; however, the optimal treatment strategy for APS-related stroke has yet to be established.
- Conditions
- Antiphospholipid Syndrome, Ischemic Stroke, Transient Ischemic Attack, Cerebrovascular Disease
- Trial name
- APS-STROKE (NCT05995600)
- Testing
- Antiplatelet Drug, Warfarin
- Where
- 32 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Irritable Bowel Syndrome, Colonic Diseases, Functional
fMRI and Visceral Perception Upon Capsaicin Infusion
Brain imaging has shown abnormal brain activations in response to visceral stimulation in patients with the Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD).
- Conditions
- Irritable Bowel Syndrome, Colonic Diseases, Functional, Dyspepsia, Gastrointestinal Diseases
- Trial name
- NCT02551029
- Testing
- Capsaicin
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Ischemic Stroke, Transient Ischemic Attack (TIA)
Addressing Sleep Apnea Post-Stroke/TIA
Effectively identifying and treating risk factors for ischemic stroke and transient ischemic attack (TIA) is important to patients, their family members, and healthcare systems.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Obstructive Sleep Apnea
- Trial name
- ASAP (NCT04322162)
- Testing
- ASAP Intervention Quality Improvement Protocol
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development