Clinical trials: Transition
Graft Dysfunction, Interstitial Fibrosis
Novartis Everolimus Transition
Transition from tacrolimus based triple therapy with Mycophenolate Mofetil (MMF) and steroids in stable renal transplant patients to low intensity tacrolimus, everolimus and prednisone will be associated with improvement in…
- Trial name
- NCT02096107
- Testing
- Everolimus, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Relapsing Multiple Sclerosis
Transition to Rebif New Formulation
To assess patient satisfaction with respect to the incidence of flu-like symptoms (FLS) in patients with multiple sclerosis transitioned from current Rebif (subcutaneously injected interferon beta-1a, 44 mcg three-times-weekly)…
- Trial name
- TRANSFER (NCT00619307)
- Testing
- Rebif New Formulation + prophylactic Ibuprofen, Rebif New Formulation + ibuprofen PRN
- Where
- 2 sites in France, Germany
- Volunteers
- 117 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Dental Implant, Single-Tooth, Esthetics, Dental
Periimplant Mucosa Dynamics Around Divergent and Concave Atlantis Abutment Transition Profiles
The purpose of this study is to compare the effect of two different implant abutment designs on gum tissue volume changes over time after implant placement.
- Trial name
- NCT01871220
- Testing
- Concave Transition Profile, Divergent Transition Profile
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Christopher Barwacz
Coronary Artery Disease (CAD)
Cangrelor to Clopidogrel or Prasugrel Transition Study
There are two separate objectives in this study: 1. To demonstrate the pharmacodynamic (PD) profile when participants treated with cangrelor are switched to oral prasugrel 60 mg administered 30 minutes (min) after cangrelor…
- Trial name
- BRIDGE (NCT01979445)
- Testing
- Cangrelor, Clopidogrel, Prasugrel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Medicines Company
Type 1 Diabetes
Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose
This study evaluates direct switching vs use of a bridging dose from insulin glargine to insulin degludec in type 1 DM patients.
- Trial name
- GLIDING (NCT04623086)
- Testing
- Insulin Degludec, Insulin Glargine
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Washington
Presbyopia
Multifocal Visual Performance Study
The purpose of this trial was to compare the functional visual performance of Precision Profile Multifocal (MF) contact lenses to Progressive Addition Lens (PAL) spectacles in a presbyopic population.
- Trial name
- NCT03757039
- Testing
- Multifocal soft contact lenses, Progressive addition lens spectacles
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 42 people
- Sponsor
- Alcon Research
College Student Drinking
Adaptive Preventive Intervention for College Alcohol Use
This research project is designed to promote health among first-year college students by implementing an adaptive sequence of preventive intervention strategies to motivate heavy-drinking college students to access existing…
- Trial name
- NCT03930524
- Testing
- Personalized Normative Feedback (PNF), Self-Monitoring (SM), Web-BASICS
- Where
- United States
- Volunteers
- 891 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Non-Small Cell Lung Cancer
Phase 2 Study of MGCD265 in Patients With Non-Small Cell Lung Cancer With Activating Genetic Alterations in MET
MGCD265 is an orally administered receptor tyrosine kinase inhibitor that targets MET and other receptors. This study is a Phase 2 trial of MGCD265 in patients with locally advanced, unresectable or metastatic non-small cell lung…
- Trial name
- NCT02544633
- Testing
- MGCD265
- Where
- 94 sites in United States, Australia and 7 more
- Volunteers
- 68 people
- Sponsor
- Mirati Therapeutics Inc.
Psychotic Disorders
Mobile After-Care Intervention to Support Post-Hospital Transition (MACS)
This study examines the feasibility and acceptability of a mobile device-delivered app, called Mobile After-Care Support (MACS), to improve patients' coping and treatment adherence following a hospitalization related to their…
- Trial name
- MACS (NCT03769493)
- Testing
- Mobile After-Care Support (MACS) app
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Butler Hospital
Heart Failure
Nurse-Led Heart Failure Care Transition Intervention for African Americans: The Navigator Program
Heart failure (HF) affects over 5 million Americans with HF morbidity reaching epidemic proportions. Annual rates of new and recurrent HF events including hospitalization and mortality are higher among African Americans.
- Trial name
- NCT01141907
- Testing
- Heart Failure Self Care Support, Usual heart failure care
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Stroke
Community Participation Transition After Stroke
Stroke is one of the most serious, disabling health conditions in the United States. Patients who undergo rehabilitation treatment for stroke have a high rate of disability.
- Trial name
- COMPASS (NCT02396589)
- Testing
- Education Group, Home Modifications Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injury
Brain Injury Rehabilitation Improving the Transition Experience
Each year, about 2.8 million people sustain a traumatic brain injury (TBI) in the United States, and at least 25 percent of these injuries are classified as moderate to severe.
- Trial name
- BRITE (NCT03422276)
- Testing
- Rehabilitation Discharge Plan, Rehabilitation Transition Plan
- Where
- 6 sites in United States
- Volunteers
- 1,555 people
- Sponsor
- University of Washington
Rheumatoid Arthritis
A Phase III Transition Study of DRL Rituximab to Reference Medicinal Products
The objective of the current study is to assess the immunogenicity and safety of transitioning subjects with RA to DRL_RI from US-rituximab/EU-rituximab to continued treatment with US-rituximab/EU-rituximab.
- Trial name
- RI-01-007 (NCT04268771)
- Testing
- Experimental: Arm A: DRL_RI, Arm B: Rituxan®/Mabthera®
- Where
- 26 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Type 2 Diabetes Mellitus
Veterans Inpatient Insulin Study and Transition to Outpatient Therapy
Volunteers are being invited to take part in a research study about insulin therapy of diabetes. They are being invited to take part in this research study because they have diabetes and have an illness requiring hospitalization.
- Trial name
- VIISTA (NCT00821795)
- Testing
- NPH/Regular 70/30 mix, insulin aspart protamine/insulin aspart 70/30 mix
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Dennis G. Karounos, M.D.
Non-small Cell Lung Cancer
Phase II of Neoadjuvant and Adjuvant Capmatinib in NSCLC
This study was planned to determine if neoadjuvant capmatinib could improve the major pathological response (MPR) in patients with Stage IB-IIIA, N2 and selected IIIB (T3N2 or T4N2) lung cancers with Mesenchymal Epithelial…
- Trial name
- Geometry-N (NCT04926831)
- Testing
- capmatinib
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Depression, Stress Disorders, Post-Traumatic
Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs
Electronic screening is effective for timely detection of, and intervention for, suicidal ideation and other mental health symptoms.
- Conditions
- Depression, Stress Disorders, Post-Traumatic, Suicide
- Trial name
- NCT04506164
- Testing
- eScreening, Screening As Usual
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cancer, Pediatric Cancer
Education Tools to Support Pediatric Survivor Care
This study aims to evaluate the impact of electronic educational materials on adolescent and young adult (AYA) survivors' knowledge about late effects, perceived benefits, self-efficacy, and intentions to engage in lifelong…
- Trial name
- NCT04257058
- Testing
- Electronic educational material
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Emory University
Substance Use Disorder, Posttraumatic Stress Disorder
Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults
The purpose of the study is to determine the safety and efficacy of an integrated treatment for substance abuse and posttraumatic stress disorder for young adults.
- Trial name
- NCT02667119
- Testing
- Prolonged Exposure with Contingency Management, Standard Care
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- UConn Health
Acute Decompensated Heart Failure
Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure
The purpose of this prospective, randomized, open-label study is to compare two diuretic strategies in patients with acute decompensated heart failure (ADHF): the addition of an oral thiazide diuretic to intravenous bolus (IVB)…
- Trial name
- NCT00904488
- Testing
- Addition of oral Metolazone, Furosemide dose escalation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Sub-acute Back Pain
Effect of L-dopa In Subacute Back Pain Population
This study aims to determine if early treatment with Carbidopa/Levodopa and Naproxen in individuals with sub-acute back pain (SBP) is associated with changes in blocking transition to chronic back pain (CBP).
- Trial name
- NCT01951105
- Testing
- Naproxen, Carbidopa/Levodopa
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University