Clinical trials: Transmission
Malaria Falciparum, Malaria Infection
Experimental Malaria Infection of Healthy Malaria-Naive Adults by Mosquito Bite With the Genetically Modified Plasmodium Falciparum NF54/iGP3 GAP
The goal of this clinical trial is to learn if the genetically-modified malaria parasite NF54/iGP3 will safely infect humans with malaria.
- Conditions
- Malaria Falciparum, Malaria Infection, Malaria Transmission
- Trial name
- iGP3-SWITCH (NCT06881732)
- Testing
- NF54/iGP3
- Where
- Australia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Risk Reduction, Occupational Exposure
Aerosol Generation in Dental Clinics
The study examines 4 different methods to reduce dental bioaerosol spread in orthodontic procedures.
- Conditions
- Risk Reduction, Occupational Exposure, Dentist-Patient Transmission
- Trial name
- NCT05468099
- Testing
- Chlorhexidine mouthwash and Povidone-Iodine, High volume evacuator, High volume evactuator and saliva ejector
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Hepatitis D Infection, Fibrosis, Liver
Find HDV and Determine Its Status in Turkey
The aim of these study to determine the prevalence of hepatitis Delta virus (HDV) infections and the prognosis of HDV patients in Turkey's southeast.
- Conditions
- Chronic Hepatitis D Infection, Fibrosis, Liver, Hepatocellular Carcinoma, Cirrhosis, Liver
- Trial name
- SITUHDVATION (NCT06248580)
- Testing
- Anti Delta
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Yaşar Bayındır, MD
Respiratory Tract Infections, Transmission
Transmission Of Respiratory Tract microOrganisms In a School Environment
Through contact with peers in daycare and (primary)school young children play a large role in spreading respiratory pathogens. In this study the investigators will investigate this transmission, the subsequent colonization and…
- Conditions
- Respiratory Tract Infections, Transmission, Microbial Colonization, Viral Respiratory Tract Infection
- Trial name
- TORTOISE (NCT06248983)
- Where
- 2 sites in Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Gut Microbiome, Mother to Child Transmission
Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function.
- Trial name
- NCT04117321
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Controlled Human Malaria Infection, Induced Blood Stage Malaria Infection
In-vivo Transmission Model in Semi-immune Adults
Controlled human malaria infection (CHMI) has revolutionized the development of malaria vaccines. It involves the administration of either known numbers of sporozoites or infected erythrocytes to healthy human volunteers under a…
- Conditions
- Controlled Human Malaria Infection, Induced Blood Stage Malaria Infection, Malaria Transmission, Malaria Challenge
- Trial name
- NCT06172686
- Testing
- Piperaquine tablets , which will be administered orally as a single dose of 480mg (320mg+160mg)., Doxycycline (100mg tablets strength as Doxycycline Hyclate) will also be administered orally and will be given as 1 tablet (100mg) Once daily for 7 days.
- Where
- Tanzania
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ifakara Health Institute
Malaria, Malaria,Falciparum
Attractive Targeted Sugar Bait Phase III Trial in Zambia
The trial will evaluate the efficacy of ATSB deployment plus universal coverage of a WHO core vector control (VC) interventions over two transmission seasons on a minimum 30% reduction in cohort clinical disease incidence…
- Conditions
- Malaria, Malaria,Falciparum, Vector-Borne Transmission of Infection
- Trial name
- NCT04800055
- Testing
- Attractive Targeted Sugar Bait
- Where
- Zambia
- Volunteers
- 3,480 people, healthy volunteers welcome
- Sponsor
- PATH
HIV Infections, Pregnancy Related
DTG Plus 3TC for Prophylaxis of Mother-to-child Transmission of HIV Infection in Pregnant Women
The study aims to evaluate the safety and efficacy of a 2 drugs ART regimen (lamivudine plus dolutegravir) for prevention of mother to child transmission in pregnant women with HIV.
- Conditions
- HIV Infections, Pregnancy Related, Mother to Child Transmission
- Trial name
- PREGNANCY (NCT04808973)
- Testing
- Dolutegravir plus lamivudine in a FDC
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundação Bahiana de Infectologia
Passive Transmission of Maternal and Infant Antibodies
Passive Transmission of COVID-19 Antibody From Mother to Infant
At present, there is no relevant research focusing on children's acquisition of novel coronavirus antibodies through maternal passive transmission.
- Trial name
- NCT05851911
- Testing
- sars-cov-2 vaccine or infection
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Covid19, SARS-CoV Infection
Effectiveness of a Novel Respirator With Chitosan Nanoparticles
The use of nanomaterials in semi-facial respirators could decrease the permeability of particles and promote a biocidal effect compared to conventional respirators (N95) and, therefore, to enhance the filtering power, aiming to…
- Conditions
- Covid19, SARS-CoV Infection, Worker-Patient Transmission, Healthcare
- Trial name
- NCT04490200
- Testing
- VESTA respirator, Conventional N95 respirator
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Helicobacter Pylori Infection, Transmission
Epidemiology of Helicobacter Pylori Infection in Children From Slovenia
The epidemiology of H. pylori infection among children in Slovenia has not been investigated. Therefore, we are conducting a study to examine the epidemiology of H. pylori and associated risk factors among children in Slovenia.
- Trial name
- NCT05846061
- Testing
- Prevalence study population
- Where
- Slovenia
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Transmission, Patient-Professional
The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations
Due to the concerns of virus transmission during COVID-19 pandemic, multiple respiratory societies postpone or limit pulmonary function test, especially cardiopulmonary exercise test (CPET), as patients may generate large amount…
- Trial name
- NCT04526925
- Testing
- Respiratory filter in-line placed with the standard mouthpiece, Standard mouthpiece
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Infections, Respiratory, Healthcare Worker Patient Transmission
Evaluation of the National Tool for Observation of Infection Prevention Measures in the Healthcare (NOST)
The Norwegian Institute of Public Health (NIPH) is introducing a new electronic tool for direct observation of compliance with recommended infection prevention and control measures in healthcare.
- Trial name
- NCT05721183
- Testing
- NOST
- Where
- Norway
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Human Immunodeficiency Virus Transmission
PC4PrEP: Integrating PrEP Into Primary Care
Oral pre-exposure prophylaxis (PrEP) has been proven effective in reducing HIV infection in high-risk men who have sex with men, heterosexually active women and men, and injecting drug users.
- Trial name
- PC4PrEP (NCT03617874)
- Testing
- PC4PrEP- Intervention Clinics, Standard of Care Clinics
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Blood Loss, Repeat Cesarean Section
Cesarean Scar Pregnancy and Clinical Outcomes
This study is a prospective cohort study, led by Prof. Zhao Yangyu, from the Department of Gynecology \& Obstetrics, Peking University Third Hospital.
- Conditions
- Blood Loss, Repeat Cesarean Section, Maternal Transmission, Hysterectomy
- Trial name
- NCT05481606
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Health Care Worker Patient Transmission
Decontamination of Incubators in a NICU (Neonatal Intensive Care Unit)
Nosocomial infections are responsible for morbidity and mortality in hospitalized neonates. The environment of the neonates and especially the incubators can constitute the reservoir of pathogenic bacteria.
- Trial name
- DECONTA (NCT04337307)
- Testing
- Skin sampling of the hands of the healthcare workers involved in the decontamination of incubators
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Staphylococcus Aureus, Health Care Associated Infection
Reducing Perioperative S. Aureus Transmission
The purpose of this study is to prevent the spread of S. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery.
- Conditions
- Staphylococcus Aureus, Health Care Associated Infection, Health Care Worker Patient Transmission
- Trial name
- NCT03638947
- Testing
- Swab and decolonization using povidone-iodine cleansing
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Randy Loftus
Close Contact Transmission
Exploratory Study of Aerosol Inhalation of FB2001 for Post-exposure Prophylaxis of COVID-19 Close Contacts
This is a single-arm, open-label, dose ramp-up exploratory clinical trial to evaluate the efficacy, safety and tolerance of aerosol inhalation of FB2001 as post-exposure prophylaxis among close contacts of COVID-19 patients.
- Trial name
- NCT05415241
- Testing
- FB2001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Hepatitis C, Transmission, Intravenous Drug Abuser
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
The principle is to propose dedicated monthly screening days bringing together the health personnel involved (hepatologist, addictologist, nurse in charge of the program, addictology nurse and social worker) and to propose…
- Conditions
- Hepatitis C, Transmission, Intravenous Drug Abuser, Addiction, Alcohol, Addiction Opiate
- Trial name
- SCANVIR (NCT05361603)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Transmission, Blood, Recipient/Donor
Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder
This study evaluates whether whole blood transferred through the new POLFA needle assembly meets supernatant hemoglobin acceptability standards.
- Trial name
- NCT02476851
- Testing
- POLFA (Needle Assembly), Kawasumi (Needle Assembly)
- Where
- 3 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation