Clinical trials: Transmission
Cytomegalovirus Retinitis, HIV Infections
A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes
To investigate the efficacy and safety of RS-79070 when used as induction therapy in patients with newly diagnosed peripheral retinitis.
- Trial name
- NCT00002377
- Testing
- Valganciclovir, Ganciclovir
- Where
- 19 sites in United States, Canada
- Sponsor
- Hoffmann-La Roche
Human Immunodeficiency Virus Type 1
A Study With TMC125 in Human Immunodeficiency Virus (HIV) Type 1 Infected Patients, Who Were Treated With TMC125 Arm in a Sponsor-Selected TMC125 Study
The purpose of this study is to evaluate the long-term safety and tolerability of etravirine, administered as part of an individually optimized antiretroviral therapy (ART), in human immunodeficiency virus Type 1 (HIV-1) infected…
- Trial name
- NCT00128830
- Testing
- Etravirine (ETR), Nucleotide reverse transcriptase inhibitors (NRTIs), Protease inhibitors (PIs)
- Volunteers
- 211 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
HIV Infections, Lipid Metabolism
Pravastatin for Hyperlipidaemia in HIV.
This study is a randomised, placebo-controlled study of the effect of treatment with the HMG-CoA reductase inhibitor, pravastatin, in HIV-infected, protease inhibitor treated patients with high serum cholesterol.
- Conditions
- HIV Infections, Lipid Metabolism, Glucose Metabolism, Metabolic Abnormality
- Trial name
- NCT00227500
- Testing
- Pravastatin
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Kirby Institute
Hearing-Impairment
Telephone vs. Voice Over IP Speech Comprehension in Hearing Aided Subjects.
Despite modern hearing aids such as cochlear implants, speech comprehension during telephone conversation is challenging for hearing-impaired patients.
- Trial name
- NCT03005912
- Testing
- Conventional acoustic telephony, Conventional bluetooth telephony, VoIP acoustic telephony
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
HIV Infections
A Phase II Efficacy Study Comparing 2',3'-Dideoxyinosine (ddI) (BMY-40900) and Zidovudine Therapy of Patients With HIV Infection Who Have Been on Long Term Zidovudine Treatment
To compare the effectiveness and toxicity of didanosine (ddI) and zidovudine (AZT) in patients with AIDS or advanced AIDS-related complex (ARC) who have tolerated AZT therapy for 12 months or longer.
- Trial name
- NCT00000671
- Testing
- Zidovudine, Didanosine
- Where
- 71 sites in United States, Puerto Rico
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections, Cytomegalovirus Retinitis
A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection
The purpose of this study is to understand how changes in the immune system of HIV-infected patients affect their risk for 3 serious infections: Pneumocystis carinii pneumonia (PCP), cytomegalovirus (CMV) retinitis, or CMV organ…
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Retinitis, Pneumonia, Pneumocystis Carinii, HIV Infections
- Trial name
- NCT00005572
- Where
- 16 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults
Background: Malaria is caused by small germs carried by mosquitoes. People can get malaria if an infected mosquito bites them. Malaria destroys red blood cells and reduces oxygen in the blood.
- Trial name
- NCT01988636
- Testing
- PfSPZ Vaccine
- Where
- Mali
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Papillomavirus Infection
Promoting HPV Vaccination Among Young Adults in Texas
This clinical trial studies how to improve the human papillomavirus (HPV) vaccination rate in young adults in Texas. This trial aims to learn more about how researchers and health care providers can increase HPV vaccination among…
- Trial name
- NCT05057312
- Testing
- Enhancing Accessibility to Health Care, Informational Intervention, Interview
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Opiate Dependence, HIV Seropositivity
Comparison of HIV Clinic-based Treatment With Buprenorphine Versus Referred Care in Heroin-dependent Participants
The purpose of this study is to compare the effectiveness of two approaches to treating HIV-infected patients who are addicted to opioid drugs (e.g., heroin) in an inner-city HIV clinic.
- Conditions
- Opiate Dependence, HIV Seropositivity, HIV Infections
- Trial name
- NCT00130819
- Testing
- Clinic-based substance abuse treatment with buprenorphine, Case management and referred substance abuse treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
AIDS Dementia Complex
Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS
This project will investigate the ability of a novel MRI contrast agent to identify and quantitate ongoing monocyte/macrophage (M/MΦ)-mediated inflammation in the brains of HIV-infected individuals.
- Trial name
- NCT02678767
- Testing
- Ferumoxytol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beau Nakamoto
Transmission, Other/Miscellaneous
Slippers to Reduce Transfer From Floors to Surfaces
The goal of this study is to determine if wearing slippers will reduce transfer of bacteriophage MS2 from hospital room floors to surfaces in the room and hands of patients.
- Trial name
- NCT04935892
- Testing
- Slippers
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Louis Stokes VA Medical Center
Papillomavirus Infections, Pregnancy Complications
Human Papillomavirus (HPV) Infection in Pregnancy
The purpose of this study is to determine if maternal infection with human papillomavirus (HPV) is associated with pregnancy complications including spontaneous preterm delivery (sPTD), severe preeclampsia (PE), and poor fetal…
- Trial name
- NCT00194311
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Infections, HIV
Using Mobile Technology and Incentives With Men Who Have Sex With Men and Transgender Women for HIV Prevention
This project called Mobile Technology and Incentives (MOTIVES) aims to increase engagement with HIV prevention information and improve testing frequency among Latino/a men who have sex with men (MSM) and transgender women (TGW).
- Trial name
- MOTIVES (NCT03144336)
- Testing
- Information provision, Weekly quizzes, Rewards for testing HIV-negative
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- RAND
Human Immunodeficiency Virus, Neurocognitive Impairment
Brain Imaging for HIV-Associated Thinking and Mood Disorders
Background: Human immunodeficiency virus (HIV) infection appears to cause problems with blood vessel function. These problems may add to some thinking and mood disorders found in people with HIV infection.
- Trial name
- NCT01692236
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections
Evaluation of an Intervention on Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV Infected Adults
It is known successful HIV therapy depends on the patients' ability to take their medicine regularly. This study is designed to find out if an intervention designed to help patients remember to take their medication is effective.
- Trial name
- NCT00203853
- Testing
- pillbox, wristwatch
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
HIV Infections, Smallpox
Safety Study of MVA Smallpox Vaccine in HIV-positive Subjects Who Are Vaccinia Naive
The purpose of this study is to assess the safety and immunogenicity of two MVA smallpox vaccine injections in healthy adults that are 18-35 years of age with HIV infection
- Trial name
- NCT00282581
- Testing
- MVA Smallpox Vaccine
- Where
- 6 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Human Immunodeficiency Virus, Hepatitis B
Notification of Donors With Positive Microbiology Markers
Each year around 200 blood donors in the UK are found to be infected with blood-borne diseases (HIV, hepatitis B, hepatitis C, and HTLV), while several others have been identified as having an increased risk of variant…
- Conditions
- Human Immunodeficiency Virus, Hepatitis B, Hepatitis C, Human T-lymphotropic Virus I & II
- Trial name
- NCT01050881
- Where
- United Kingdom
- Volunteers
- 217 people
- Sponsor
- NHS Blood and Transplant
HIV Infection
Single DermaVir Immunization in HIV-1 Infected Patients on HAART
DermaVir is a plasmid DNA-containing synthetic nanomedicine. It is administered topically with DermaPrep to target Langerhans cells.
- Trial name
- GIHU004 (NCT00712530)
- Testing
- DermaVir, HAART
- Where
- Hungary
- Volunteers
- 9 people
- Sponsor
- Genetic Immunity
HIV Infection
Intermittent Versus Continuous Medication in the Treatment of HIV
Although highly active antiretroviral therapy (HAART) has been successful in suppressing plasma HIV RNA levels in infected patients, it has not resulted in eradication of virus.
- Trial name
- NCT00001967
- Testing
- HAART
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Safety of AMD070 When Administered Alone or Boosted With Low-Dose Ritonavir in HIV Uninfected Men
Most currently approved anti-HIV drugs work by stopping the replication of HIV after it has entered cells. AMD070 (also known as AMD11070) is designed to block HIV from entering cells and may be effective in treating patients who…
- Trial name
- NCT00063804
- Testing
- Ritonavir, AMD070
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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