Clinical trials: Transplant, Liver
Liver Transplant Disorder, Liver Cirrhosis
Totally Extraperitoneal Repair of Groin Hernia in Liver Transplanted Patients
Liver transplant recipients share the risk with cirrhotic patients for the development of inguinal hernias, but their liver failure pathophysiology has reversed following transplantation.
- Conditions
- Liver Transplant Disorder, Liver Cirrhosis, Groin Hernia
- Trial name
- TOHER (NCT05378451)
- Testing
- Totally Extraperitoneal Groin Hernia Repair
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplant Disorder
Perioperative Factors and Living Donor Liver Transplantation
Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis.
- Trial name
- NCT06312098
- Testing
- remote ischemic preconditioning (RIPC)
- Volunteers
- 533 people
- Sponsor
- Min Suk Chae
Liver Transplant; Complications
Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation
The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion.
- Trial name
- NCT06307158
- Volunteers
- 998 people
- Sponsor
- Zhejiang University
Liver Transplantation, Transplant Recipients
A Cohort Study on the Pathogen Spectrum of Liver Transplant Recipients Complicated With Infection
The goal of this observational study is to map the pathogen profile of secondary infections in liver transplant recipients, to correlate the basic immune status with the characteristics of the secondary infection pathogen…
- Trial name
- NCT06279884
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang University
Liver Transplant; Complications
Use of Fibrin Sealant Patch for Vein Anastomosis During Deceased Donor Liver Transplantation- Randomized Clinical Trial
The study aims to evaluate the effect of the hemostatic matrix with fibrinogen and thrombin (TachoSil®) on vena cava inferior anastomoses during liver transplantation from a deceased donor.
- Trial name
- HemoCava (NCT06124209)
- Testing
- TachoSil
- Where
- Poland
- Volunteers
- 170 people
- Sponsor
- Medical University of Warsaw
Rheumatoid Arthritis, Psoriatic Arthritis
Vaccine Response to COVID-19 Vaccines in Patients Using Immunosuppressive Medication
The purpose of this study is to assess the strength and duration of the immunological response to COVID-19 vaccines in patients treated with immunosuppressive and/or immunomodulating medication for immune-mediated inflammatory…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Spondyloarthritis, Crohn Disease
- Trial name
- Nor-vaC (NCT04798625)
- Where
- 2 sites in Norway
- Volunteers
- 2,300 people
- Sponsor
- Diakonhjemmet Hospital
Eating Behaviour, Liver Transplant
Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients
Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in…
- Trial name
- GREFFE (NCT02859506)
- Testing
- Respiratory quotient, Olfactory liking
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sinusoidal Obstruction Syndrome, Complications of Bone Marrow Transplant
Using Ultrasound Elastography to Predict Development of SOS
Sinusoidal obstruction syndrome (SOS) is a potentially fatal hepatic veno-occlusive disease-affecting children following bone marrow transplantation (BMT).
- Trial name
- NCT02483481
- Testing
- shear wave ultrasound elastography
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Mercy Hospital Kansas City
Hepatocellular Carcinoma, Liver Transplant; Complications
Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver Transplantation
The use of devices for liver grafts perfusion before transplantation, either hypothermic (HOPE) or normothermic (NMP), is rapidly spreading thanks to the promising results obtained so far in terms of graft survival and…
- Trial name
- NCT06236568
- Testing
- D-HOPE machine perfusion, Liver transplantation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Liver Transplant; Complications
High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation A Randomized, Controled, Open and Unicentric Trial.
LIVER PAM A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.
- Trial name
- LIVER-PAM (NCT05068713)
- Testing
- Usual Care + High Target of Mean Arterial Pressure, Usual Care
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- University of Sao Paulo General Hospital
Liver Transplant
OCS Liver PROTECT Continuation Post-Approval Study
Post-approval observational study of subjects that were enrolled and transplanted in the OCS Liver PROTECT Trial.
- Trial name
- NCT05096741
- Testing
- OCS Liver
- Where
- 17 sites in United States
- Volunteers
- 300 people
- Sponsor
- TransMedics
Liver Transplant
PREPARE- Prehabilitation for Patients Awaiting Liver Transplantation: Feasibility and Acceptability Testing.
This is a study developing a prehabilitation intervention and then testing the acceptability and feasibility of the intervention.
- Trial name
- PREPARE (NCT06036225)
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Belfast Health and Social Care Trust
Liver Transplant
Safety and Efficacy of Perioperative Remodulin® in Orthotopic Liver Transplant Recipients
Patients undergoing orthotopic liver transplant will experience some degree of clinical and/or biochemical hepatic dysfunction. This early injury is known as primary graft dysfunction and varies from minor abnormalities to…
- Trial name
- NCT01884038
- Testing
- treprostinil sodium
- Where
- United States
- Sponsor
- United Therapeutics
Immune Tolerance, Liver Transplant; Complications
Immune Tolerance After Pediatric Liver Transplantation
Immunosuppressive (IS) agents are effective treatment to avoid acute or chronic rejection after pediatric liver transplantation.
- Trial name
- NCT05501301
- Testing
- IS weaning off
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Liver Transplant
OCS Liver PROTECT Continued Access Protocol (CAP) Continuation Post-Approval Study
Post-approval observational study of subjects that were enrolled and transplanted in the OCS Liver PROTECT CAP.
- Trial name
- NCT05096754
- Testing
- OCS Liver
- Where
- 11 sites in United States
- Volunteers
- 74 people
- Sponsor
- TransMedics
Immune Tolerance, Immunosuppression
Efficacy and Safety of Immunosuppressive Withdrawal After Pediatric Liver Transplantation
The goal of this clinical trial is to learn about the efficacy and safety of immunosuppressive withdrawal in pediatric liver transplant recipients.
- Conditions
- Immune Tolerance, Immunosuppression, Liver Transplant; Complications
- Trial name
- NCT06147375
- Testing
- Tacrolimus or Cyclosporine A
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Wei Gao
Liver Transplant; Complications, Vaccination; Complications
VACcination of LIver Transplantation Candidates
Chronic hepatic disease, and especially cirrhosis, are associated to a global dysfunction of the immune system. Liver transplantation represents the only replacement therapy for end-stage liver disease and a curative means of…
- Conditions
- Liver Transplant; Complications, Vaccination; Complications, Cirrhosis, Chronic Hepatitis
- Trial name
- VacLit (NCT04446832)
- Testing
- Vaccine immunogenicity
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Liver Transplant; Complications
Hepatitis B Virus Reactivation: a Cautionary Event After Liver Transplantation for Patients With Hepatocellular Carcinoma
Highly active hepatitis B virus (HBV) is known to be associated with poor outcomes in patients with hepatocellular carcinoma (HCC).
- Trial name
- NCT06114251
- Testing
- Diagnosis of postoperative recurrence of liver cancer
- Volunteers
- 920 people
- Sponsor
- Zhejiang University
Liver Transplant; Complications, Transplant; Failure, Liver
Liver Transplantation After ex Vivo Liver Perfusion
Today, it is difficult to predict liver function after transplantation and therefore livers where poor function is assumed (marginal livers) become discarded.
- Conditions
- Liver Transplant; Complications, Transplant; Failure, Liver, Transplant Dysfunction, Transplant; Complication, Rejection
- Trial name
- EVOLVE (NCT05951231)
- Testing
- Liver transplantation
- Volunteers
- 22 people
- Sponsor
- Oslo University Hospital