Clinical trials: Transplant, Liver
Hepatic Veno-Occlusive Disease
Pediatric Trial Investigating the Incidence & Outcome of Veno-Occlusive Disease With the Prophylactic Use of Defibrotide
The aim of this trial is to evaluate whether the prophylactic use of Defibrotide (DF) in pediatric patients (age less than 18 years) undergoing stem cell transplantation and who are at high risk of developing hepatic…
- Trial name
- VOD-DF (NCT00272948)
- Testing
- Defibrotide
- Where
- 30 sites in Austria, France and 8 more
- Volunteers
- 360 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Hepatitis B, Chronic
KRN7000 in Chronic Hepatitis B
The purpose of this trial is to determine the safety, tolerability and effectiveness of KRN7000 for chronic hepatitis B infection.
- Trial name
- NCT00363155
- Testing
- KRN7000
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Foundation for Liver Research
Venous Thromboembolism, Liver Transplantation
Risk Factors and a nOmogram of Venous thromboEmbolism in Patients After liveR Transplantation(ROVER Study)
Liver transplantation is currently an effective treatment for end-stage liver disease. The high incidence of thrombotic related complications in the early postoperative period after orthotopic liver transplantation(OLT) has been…
- Trial name
- NCT05209048
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Hepatitis B
Evaluating Blood Glucose Levels During Infusion With HepaGam B (HBIG) in Post-liver Transplant Patients
HepaGam B Hepatitis B Immune Globulin (HBIG) solution contains 10% maltose, which could possibly interfere with the measurement of glucose levels when using glucose non-specific tests.
- Trial name
- NCT00998426
- Testing
- glucose monitoring before and after HepaGam B administration, HepaGam B (Hepatitis B Immune Globulin (HBIG))
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Georgetown University
Hepatitis B, Chronic
Nabi-HB Administered Subcutaneously in Patients With Hepatitis B Virus Post Liver Transplantation
A phase 3, multicenter, open label study to assess the safety and efficacy of Nabi-HB, administered subcutaneously in patients with Hepatitis B Virus Associated Liver Disease who underwent liver transplantation.
- Trial name
- Nabi-HB-SC (NCT00800787)
- Testing
- Nabi-HB
- Sponsor
- Biotest Pharmaceuticals Corporation
Liver Transplant Disorder, Self Efficacy
Effectiveness of Intelligent Case Manage Platform in Liver Transplant Recipients
This study is a prospective, quasi-experimental design, with an experimental group and a control group, will be created. The aims of this study are as follows: 1.
- Conditions
- Liver Transplant Disorder, Self Efficacy, Quality of Life
- Trial name
- ICMP (NCT05953948)
- Testing
- Intelligent Case Manage Platform (ICMP) and self-management program
- Where
- Taiwan
- Volunteers
- 333 people
- Sponsor
- Chang Gung University
Liver Transplant, Hepatitis C
Liver Fibrosis in Patients Transplanted for Hepatitis C Receiving Either Cyclosporine Microemulsion or Tacrolimus
Following a transplant for hepatitis C cirrhosis, the infection comes back in 70-90% of cases and over time causes fibrosis and eventually cirrhosis of the new liver.
- Trial name
- NCT00260208
- Testing
- Cyclosporine A, Tacrolimus
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 361 people
- Sponsor
- Novartis Pharmaceuticals
Acute-On-Chronic Liver Failure, Acute Liver Failure
The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) refers to a liver failure syndrome in which some patients with chronic liver disease with relatively stable liver function suffer from acute liver decompensation and liver failure due to the…
- Trial name
- NCT05940610
- Testing
- MSC-EVs
- Where
- China
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Transplant; Complications, Neurologic Complication
Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation
Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation.
- Conditions
- Liver Transplant; Complications, Neurologic Complication, Postoperative Complications
- Trial name
- NCT04188717
- Volunteers
- 253 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplant
Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function.
- Trial name
- ELIMINATE (NCT06280950)
- Testing
- Everolimus, Tacrolimus (continued reduction), Tacrolimus (maintain 50% reduction)
- Where
- 12 sites in United States
- Volunteers
- 340 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Dysfunction
Influence of CYP3A5 Polymorphism on Liver Function Abnormality and the Trough Level Change After Conversion
This study is a multicenter, single-arm, open-label, 24 weeks, and investigator-initiated clinical trial to assess the influence of CYP3A5 polymorphism on liver function abnormality and the trough level change after conversion to…
- Trial name
- NCT02882113
- Testing
- Advagraf
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Liver Transplantation
Viability Testing and Transplantation of Marginal Livers
This study is designed to determine if a rejected liver is viable using normothermic machine liver perfusion (NMLP). It aims to 1.
- Trial name
- VITTAL (NCT02740608)
- Testing
- OrganOx metra
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Birmingham
Hypotension After Reperfusion in Liver Transplantation
Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the…
- Trial name
- NCT01080625
- Testing
- phenylephrine, epinephrine
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seoul National University Hospital
Liver Diseases, Kidney Diseases
Clinical Trial of New Hypothermic Oxygenated Perfusion System Versus Static Cold Storage
With the present study the investigators will evaluate the benefit of end-ischemic HOPE on ECD grafts (livers and kidneys) as compared to SCS.
- Trial name
- NCT03837197
- Testing
- Kidney-Hypothermic oxygenated, Liver-Hypothermic oxygenated
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Bologna
Liver Disease
Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus…
- Trial name
- NCT01958190
- Testing
- Tacrolimus and Sirolimus, Tacrolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Foundation for Liver Research
Liver Transplantation
Hypothermic Oxygenated Perfusion for Extended Criteria Donors in Liver Transplantation (HOPExt)
Given the scarce donor supply, an increasing number of so-called marginal or extended criteria donor (ECD) organs have been used for liver transplantation.
- Trial name
- HOPExt (NCT03929523)
- Testing
- End-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE), classic static cold storage
- Where
- 8 sites in France
- Volunteers
- 266 people
- Sponsor
- Hospices Civils de Lyon
HBV, Kidney Transplantation
Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
Solid Organ Transplantation (SOT) is made possible by the use of a lifelong immunosuppressive treatment. This treatment limits the response of the immune system, enabling long-term survival of the transplanted organ, but also…
- Conditions
- HBV, Kidney Transplantation, Liver Transplantation
- Trial name
- VITAMIN (NCT06307808)
- Testing
- Tacrolimus, Belatacept
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Liver Transplantation, Immunosuppression
Extracorporeal Photopheresis in Liver Transplantation. Phase II Clinical Trial in Safety and Efficacy in Patients With Gradual Decrease of Immunosuppression.
The purpose of this study is to evaluate the safety of extracorporeal photopheresis in patients with long-standing liver transplantation subjected to a progressive reduction of immunosuppression by complications arising from its…
- Trial name
- FEC-TH (NCT01824368)
- Testing
- Extracorporeal Photopheresis Procedure (FEC)
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Red de Terapia Celular
Living Donor Liver Transplantation Recipients
Pressure Controlled Versus Volume Controlled Mechanical Ventilation During Anesthesia for Living Donor Liver Transplantation Recipients
pressure controlled ventilation will improve oxygenation indices , hemodynamics during anesthesia for living donor liver transplantation recipients ,improving postoperative graft function and decreasing postoperative pulmonary…
- Trial name
- NCT01865019
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Transplantation, Liver
A Trial to Assess Campath-1H and Tacrolimus Followed by Immunosuppression Withdrawal in Liver Transplantation
This is a prospective, multicenter open-label single arm trial in which recipients of liver allograft will receive uniform immunosuppressive induction and maintenance regimens.
- Trial name
- NCT00166556
- Testing
- Campath-1H and Tacrolimus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
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