Clinical trials: Transplant, Liver
Liver Transplantation
Endotracheal Cardiac Output Monitor (ECOM) for Patients Undergoing Liver Transplantation
The purpose of this study is to determine whether the endotracheal cardiac output monitor (ECOM) is accurate and predictive in liver failure patients with hyperdynamic circulatory changes.
- Trial name
- NCT01299441
- Testing
- ECOM ETT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Hepatocellular Carcinoma (HCC), Living Donor Liver Transplantation
Efficacy of Loco-regional Treatment for Hepatocellular Carcinoma Prior to Living Donor Liver Transplantation in Egypt
This study aimed to analyze the outcomes of loco-regional treatment prior Living Donor Liver Transplantation in patients with HCC.
- Trial name
- NCT02990351
- Testing
- loco regional therapies for HCC
- Volunteers
- 29 people
- Sponsor
- Ain Shams University
Chronic Liver Disease
Comparing Portal Vein Assessment by Intraoperative Doppler and Transesophageal Echocardiography
Liver transplantation is usually associated with hemodynamic instability. TEE allows for a real time monitoring of cardiac structures and has become a standard of care for liver transplant patients.
- Trial name
- NCT06909175
- Testing
- Transesophageal echocardiography
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Intraoperative Bleeding
The Efficacy of the Administration of Fibrinogen in Liver Transplantation
Objective: To evaluate the efficacy of preoperative administration of fibrinogen in liver transplantation by maintaining a preoperative plasma level equal to 2.9 g / L compared with placebo, reflecting a reduction in the number…
- Trial name
- FibstudLT (NCT01539057)
- Testing
- Fibrinogen, Saline
- Where
- 4 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Liver Transplant; Complications
Darbepoetin in Patients Candidates for Liver Transplant. (EPO-LT Trial)
This is a national multicenter, randomized clinical trial to evaluate the the efficacy and safety of DP administration in patients on the liver transplant waiting list to reduce intraoperative red blood cell concentrate…
- Trial name
- EPO-LT (NCT07169643)
- Testing
- Darbepoetin (DP)
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Liver Failure
Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients
The purpose of this study is to demonstrate the pharmacokinetics (PK, measuring the amount of medication in blood samples) and safety of a new medicine, LCP-Tacro™ tablets, and Prograf® capsules, a drug commonly taken by…
- Trial name
- NCT00772148
- Testing
- LCP -Tacro, Prograf
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Veloxis Pharmaceuticals
Transplantation
Hepatitis E Virus Infection in Pediatric Transplantation, a Prevalence Study
Hepatitis E virus (HEV) is an emerging disease. The genotype 1 and 2 are predominant in Asia and Africa, and are responsible for recurrent epidemics.
- Trial name
- HEV (NCT02809885)
- Testing
- Hepatitis E serology
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
Mindfullnes-Based Cognitive Therapy and Adherence to Immunosuppressive Therapy
Mindfullnes-Based Cognitive Therapy Effect
Objective: In this study, the effect of mindfulness-based cognitive therapy on compliance with immunosuppressive therapy in liver transplant patients was evaluated.
- Trial name
- [Mindfullnes] (NCT05995938)
- Testing
- Mindfullnes-Based Cognitive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- SEMRA BÜLBÜLOĞLU
Liver and Biliary Tract Disorders in Duration of Pregnancy, Other End-stage Liver Diseases in Children
Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study
The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort.
- Trial name
- NCT06045949
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Huiwu Xing
Postoperative Ileus
Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation
Postoperative ileus is a common after abdominal surgery. Multifactorial etiology such as surgical trauma, bowel manipulation and perioperative opioids contributes to delayed return of normal gut function Chewing gum has recently…
- Trial name
- NCT01956643
- Testing
- gum chewing, Control
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Liver Transplantation
Reduction in the Risk of Rejection by Mycophenolate Mofetil Dose Adjustment in Liver Transplant Patients With Side Effects Caused by the Calcineurine Inhibitors
The aim of this project is to determine whether, in liver transplant patients with side effects due to ICN, the use of MMF in monotherapy can be optimised by dose adjustment based on the area under the curve (AUC) of mycophenolic…
- Trial name
- MONOCEPT (NCT00456235)
- Testing
- Mycophénolate Mofétil, Ciclosporine A, Tacrolimus
- Where
- 17 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Limoges
Hepatocellular Carcinoma (HCC), Liver Transplantation
Validation of the TRAIN-AI for the Risk of HCC Recurrence After Liver Transplantation
Liver transplantation (LT) is the best treatment option for patients with early stages of hepatocellular carcinoma (HCC).1 However, the use of LT depends on maintaining a balance between the risk of post-transplant recurrence or…
- Conditions
- Hepatocellular Carcinoma (HCC), Liver Transplantation, Deep Learning Model
- Trial name
- TRAIN-AI (NCT06799468)
- Testing
- liver transplantation
- Volunteers
- 1,769 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Non-Alcoholic Fatty Liver Disease, Non Alcoholic Steatohepatitis
Fecal Microbiota Transplantation for the Treatment of Non-Alcoholic Steatohepatitis
Human microbiota is the set of microorganisms that, in a symbiotic way, coexist and develop in the different surfaces (skin and mucous membranes) of the human body.
- Trial name
- FMT-NASH (NCT03803540)
- Testing
- Fecal Microbiota Transplantation
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Puerta de Hierro University Hospital
Recurrent Liver Cancer After Liver Transplantation
Hepatic Arterial Infusion Chemotherapy in Combination With Atezolizumab and Bevacizumab for Second-line Treatment of Patients With Recurrent Liver Cancer After Liver Transplantation
For patients with recurrent liver cancer after liver transplantation, the median survival time is low and the prognosis is often poor.
- Trial name
- NCT05833126
- Testing
- Hepatic arterial infusion chemotherapy + Atezolizumab and bevacizumab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shuhong Yi
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Carcinoma, Hepatocellular
Safety and Efficacy of Everolimus Treatment in Liver Transplantation for Liver Cancer
This study is a prospective Phase IV study to determine if the use of Everolimus results in lower liver tumor recurrence and improved patient and graft survival after liver transplant for hepatocellular carcinoma (HCC).
- Trial name
- NCT02081755
- Testing
- Everolimus, Tacrolimus, Myfortic
- Where
- 9 sites in United States
- Volunteers
- 336 people
- Sponsor
- Baylor Research Institute
Liver Transplantation
A New Prediction Mode for Predicting the Risk of Pressure Injury in Patients Undergoing Liver Transplantation
Pediatric population is at a high-risk of pressure injury (PI). Patients undergoing liver transplantation are more prone to PIs compared with other types of surgery.
- Trial name
- PMPRPIULT (NCT05588271)
- Testing
- Exposures
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Liver Transplantation
A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Liver Transplant Patients
A study to assess the pharmacokinetics, safety and effectiveness of tacrolimus in stable liver transplant patients converted from a tacrolimus (Prograf®) based immunosuppression regimen to a modified release tacrolimus based…
- Trial name
- NCT00282243
- Testing
- tacrolimus modified release (MR), tacrolimus
- Where
- 10 sites in United States
- Volunteers
- 70 people
- Sponsor
- Astellas Pharma Inc
Thrombocytopenia
Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation
This project is a pilot randomized controlled trial aimed at investigating the potential of Carica Papaya Leaf Extract, available in a marketed pill formulation, in increasing platelet counts in live donor liver transplant…
- Trial name
- NCT05360134
- Testing
- Carica Papaya Leaf Extract
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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