Clinical trials: Transplant, Liver
Hepatocellular Injury, Liver Transplant Disorder
Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation
The common practice of conventional cold storage (CCS) organ preservation has changed little since the initial introduction of the original University of Wisconsin (UW) organ preservation solution in the late 1980s.
- Trial name
- HOPE-NMP (NCT04644744)
- Testing
- Hypothermic oxygenated perfusion (HOPE), Normothermic machine perfusion (NMP)
- Where
- 4 sites in Germany
- Volunteers
- 213 people
- Sponsor
- Charite University, Berlin, Germany
Mucopolysaccharidosis Disorders, Hurler Syndrome
MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis
This single-institution, phase II study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) using busulfan- and fludarabine-based…
- Conditions
- Mucopolysaccharidosis Disorders, Hurler Syndrome, Hunter Syndrome, Maroteaux Lamy Syndrome
- Trial name
- NCT02171104
- Testing
- Stem Cell Transplantation, IMD Preparative Regimen, Osteopetrosis Only Preparative Regimen
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hepatocellular Carcinoma
Intravascular Ultrasound for Hepatocellular Carcinoma Staging
To diagnose hepatocellular carcinoma (HCC) and to determine the extent of the disease, a triphasic CT scan or a magnetic resonance imaging are required.
- Trial name
- NCT00474734
- Testing
- Intravascular ultrasound of the liver
- Where
- Switzerland
- Sponsor
- University Hospital, Geneva
Coagulopathy, Liver Transplantation
Clinical Evaluation of the Hemosonics Quantra® Coagulation Monitor in Liver and Multivisceral Transplantation
Severe coagulopathy and operative bleeding are common in liver and multivisceral transplant recipients. This is related to reduced synthesis and function of clotting proteins in end-stage liver disease, thrombocytopaenia…
- Trial name
- NCT04274699
- Testing
- Hemosonics Quantra coagulation monitor
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Chronic Graft-Versus-Host Disease (cGVHD)
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD.
- Trial name
- NCT06619561
- Testing
- Vimseltinib
- Where
- 26 sites in United States
- Volunteers
- 48 people
- Sponsor
- Deciphera Pharmaceuticals, LLC
Liver Transplantation
Post-Static Cold Storage Hypothermic Oxygenated Perfusion in Bergamo Liver Transplant Program
In light of the widespread organ shortage, dynamic preservation by means of Machine Perfusion (MP) has been proposed as a strategy to increase the pool of suitable grafts for liver transplantation.
- Trial name
- NCT03098043
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Papa Giovanni XXIII Hospital
Hepatocellular Carcinoma, Cirrhosis
The Dual Impact of Cirrhosis on Transplantation for Hepatocellular Carcinoma：a Two-center Retrospective Cohort Study in China
Background: This study aims to investigate the correlation between cirrhosis and hepatocellular carcinoma (HCC) recurrence after Liver Transplantation.
- Trial name
- NCT06420791
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Xiao Xu
Sarcopenia
Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation After Liver Transplantation
Sarcopenia is an independent predictor of morbidity and mortality in cirrhotic patient before and after liver transplantation. Beta-hydroxy-beta-methyl butyrate (HMB) is a leucine metabolite with potential efficacy in increasing…
- Trial name
- HMB (NCT03234920)
- Testing
- BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB)
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- University of Roma La Sapienza
Evidence of Liver Transplantation
Changes of Macrophage Migration Inhibitory Factor During Orthotopic Liver Transplantation
Collecting blood, graft liver effluent and urine samples from patients undergoing orthotopic liver transplantation.
- Trial name
- NCT02695979
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Liver Transplantation
Evaluation of Pulmonary Complications in Liver Transplantation Patients Based on Machine Learning
The main objective of this study is to develop a machine learning model that predicts moderate-severe prediction model of pulmonary complications in liver transplantation patients within 14 postoperative day using a real-world…
- Trial name
- NCT06534840
- Where
- China
- Volunteers
- 400 people
- Sponsor
- West China Hospital
Zhejiang University
Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and…
- Trial name
- NCT06359496
- Testing
- No intervention factor
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Hepatocellular Carcinoma
Genetic Profiling of Liver Cancer in Patients Undergoing Liver Transplantation
The purpose of this study is to determine whether genetic markers unique to liver cancer are present and to assess usefulness as a diagnostic tool.
- Trial name
- NCT02412579
- Testing
- None - Standard of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Transplant; Failure, Heart, Hepatitis C
The Hepatitis C Transplant Collaborative
In this study we seek to test the hypothesis that safety and clinical outcomes after cardiac transplantation utilizing HCV NAT+ donor organs as currently performed are acceptable.
- Trial name
- NCT04493385
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Hepatocellular Carcinoma Recurrent, Hepatocellular Carcinoma
Association Between Pre-op Non-Selective Beta-Blockers and Hepatocellular Carcinoma Recurrence Post-Liver Transplant
The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver…
- Trial name
- NCT06233708
- Testing
- Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use
- Volunteers
- 2,092 people
- Sponsor
- Asan Medical Center
Tissue and Organ Harvesting, Liver Transplantation
Evaluation of Liver Grafts With FibroScan® Before Organ Retrieval in Patients With Brain Death
According to the French Biomedicine Agency annual report on retrieval activities and transplants, 1,164 liver transplants were performed in 2011 and 1,161 in 2012.
- Conditions
- Tissue and Organ Harvesting, Liver Transplantation, Brain Death
- Trial name
- FIBROSCAME (NCT02460250)
- Testing
- Fibroscan
- Where
- 19 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Limoges
Hepatocellular Carcinoma, Liver Transplantation
Relenvatinib in the Tatment of Recurrence of Hepatocellular Carcinoma After Liver Transplantation
The aim of this study is to evaluate the efficacy and safety of lenvatinib in the treatment of recurrence of hepatocellular carcinoma after liver transplantation.
- Trial name
- RRHCCLT (NCT04237740)
- Testing
- relenvatinib
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Evidence of Liver Transplantation, Arterial Occlusive Diseases
Clinical Benefits of B-Flow Ultrasound
The goals of this study are to evaluate the efficacy of the B-flow capability on the LOGIQ E9 system in three clinical focus areas. 1.
- Conditions
- Evidence of Liver Transplantation, Arterial Occlusive Diseases, Hypertension, Pregnancy, High Risk
- Trial name
- NCT02008097
- Testing
- GE LOGIQ E9 Ultrasound System
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Washington
Hepatocellular Carcinoma
Phase 1-2 Trial HCQ Plus TACE in Unresectable HCC
Primary Phase I:To determine dose limiting toxicities and maximum tolerated dose (MTD) of the oral administration of hydroxychloroquine (HCQ) in conjunction with transarterial chemoembolization (TACE) in treating hepatocellular…
- Trial name
- NCT02013778
- Testing
- HCQ
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Liver Transplant Infection
Impact of a TDM-guided ECPA Program for Optimizing Pharmacodynamic Target Attainment of Continuous Infusion Beta-lactam-based Regimen
Previous studies have clearly demonstrated a significant impact of optimised antibiotic therapy based on a TDM-guided approach in reducing the clinical and microbiological failure rate and in improving the achievement of an…
- Trial name
- NCT06718517
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Transplant
Outcomes and Risk Factors for Liver Transplantation Using Significant Fibrotic Grafts
This is a multi-center study to investigate the impact of fibrotic liver greafts in liver transplant recipient.
- Trial name
- NCT07101718
- Testing
- No intervention
- Where
- China
- Volunteers
- 25,419 people
- Sponsor
- Zhejiang University
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