Clinical trials: Transplant, Liver
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Liver Failure
Allogeneic Bone Marrow Mesenchymal Stem Cells Transplantation in Patients With Liver Failure Caused by Hepatitis B Virus (HBV)
Allogeneic Bone Marrow Mesenchymal Stem Cells Transplantation in Patients with Liver Failure Caused by hepatitis B virus (HBV)
- Trial name
- NCT01322906
- Testing
- Group 1, Group 2, Group 3
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Liver Failure, Liver Cirrhosis
Study of Oxidized Albumin in Liver Transplant Patients
The overall goal is to describe the oxidation state of albumin before, during and after liver transplantation. This is a pilot observational study in which the oxidative state in 10 patients undergoing liver transplantation will…
- Conditions
- Liver Failure, Liver Cirrhosis, Liver Transplant Disorder
- Trial name
- SALT (NCT06772298)
- Volunteers
- 10 people
- Sponsor
- Region Stockholm
Organ Transplant, Ischemic Reperfusion Injury
PERTRIAL - Perla® Preservation Solution
Perla® is a Cold Preservation Solution, with purpose to wash out, preserve during transport liver and kidney grafts in optimal conditions from the donor to the recipient.
- Trial name
- NCT05194306
- Testing
- Perla® Cold Preservation solution
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Advanced Life Solutions
Hypertension
Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus Toxicity
Pharmacokinetics of Tacrolimus and Sirolimus alone and in combination in liver transplant recipients.
- Trial name
- Sirolimus (NCT01709136)
- Testing
- Sirolimus
- Volunteers
- 3 people
- Sponsor
- University of Pittsburgh
Liver Transplant Failure
Liver Graft Viability Assessment During Normothermic Regional Perfusion
With the increasing shortage of available donor organs, liver transplantation from donation after circulatory death (DCD) has been established in many countries to offer a therapeutic strategy for patients with end-stage liver…
- Trial name
- MAASTR3BOLOMIC (NCT05361044)
- Testing
- Blood samples Donnor
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Liver Transplant; Complications, Surgical Injury
Magnetic Spiderman for Preparation of Liver Donation
Due to many vascular branches on the supra-hepatic vena cava (SHVC) and infra-hepatic vena cava (IHVC), in the whole procedures of preparation of liver donation, preparation of hepatic vena cava (HVC) is the most key and…
- Trial name
- MSPLD (NCT04182256)
- Testing
- MS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cirrhosis, Liver, Sarcopenia
Body Composition Changes After TIPS and Associated Clinical Outcomes
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients…
- Trial name
- NCT05420753
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Liver Transplant Recipient
Micafungin Versus Fluconazole for Prevention of Invasive Fungal Disease in Living Donor Liver Transplant Recipients
The purpose of this study is to demonstrate non-inferiority of micafungin at a dose of 100 mg/day versus fluconzeole for the prevention of Invasive Fungal Disease, defined according to the revised EORTC/MSG criteria, undergoing…
- Trial name
- KOPIN (NCT01974375)
- Testing
- micafungin, Fluconazole
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Asan Medical Center
Inpatient With End Stage Liver Disease
Is Access to Liver Transplantation Similar in Alcoholic or Not Patients?
The purpose of this study is to determine whether there are reasons other than medical reasons that could limit access to liver transplantation in alcoholic patients.
- Trial name
- TRANSALC (NCT01820819)
- Where
- France
- Volunteers
- 574 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Sclerosing Cholangitis (PSC)
Endoscopy and Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis (PSC) is a chronic, cholestatic, immune-mediated liver disease characterized by segmental inflammation, fibrosis and destruction of the intra and / or extrahepatic biliary tree.
- Trial name
- NCT06686810
- Testing
- Endoscopic Retrogradade CholangioPancreatography (ERCP)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Education
Video-supported Training in Line With the Health Belief Model
Summary The only treatment method for those with incurable, irreversible, progressive, acute or chronic liver disease is liver transplantation.
- Trial name
- NCT06138379
- Testing
- Experimental: 1st Experimental Group, Experimental: 2nd Experimental Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Diseases, Liver Cirrhosis
Intraoperative Phlebotomies and Bleeding in Liver Transplantation
Liver transplantation are surgeries associated with important bleeding and often require perioperative red blood cell (RBC) transfusions.
- Conditions
- Liver Diseases, Liver Cirrhosis, Surgery, Surgery--Complications
- Trial name
- TOF_PHLEBO (NCT04826666)
- Where
- Canada
- Volunteers
- 679 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Immunosuppression
Fibroscan to Guide Post Transplant Immunosuppression Minimization
Following Liver transplantation, recipients remain on life long immunosuppression. Prolonged exposure to immunosuppression is associated with side effects and complications including kidney dysfunction, diabetes, heart disease…
- Trial name
- NCT07206277
- Testing
- Immunosuppression reduction
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Immune Tolerance, Immunosuppression
Efficacy and Safety of Immunosuppressive Withdrawal After Pediatric Liver Transplantation
The goal of this clinical trial is to learn about the efficacy and safety of immunosuppressive withdrawal in pediatric liver transplant recipients.
- Conditions
- Immune Tolerance, Immunosuppression, Liver Transplant; Complications
- Trial name
- NCT06147375
- Testing
- Tacrolimus or Cyclosporine A
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Wei Gao
Liver Preservation
Trial of the TransMedics Organ Care System™ Liver For Preserving and Assessing Donor Livers for Transplantation
A prospective, single-center controlled trial to evaluate the safety and performance of the portable Organ Care System (OCS) Liver for preservation and assessment of donor livers for transplantation.
- Trial name
- REVIVE (NCT02449694)
- Testing
- OCS Liver
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- TransMedics
Cirrhosis, Hepatocellular Carcinoma
Hepatocellular Carcinoma Growth and Molecular Aggressiveness
Our long-term objective is to develop a new tool based on a (molecular-biology) integrated imaging technology able to characterize and categorize hepatocellular carcinoma (HCC) patients in need of liver transplant (LT).
- Trial name
- UniRer (NCT01657695)
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Prof. Facchinetti Fabio
Orthotopic Liver Transplantation
Enteric Microbiome and Liver Transplantation
Liver transplantation (LT) has changed the life expectancy of end-stage liver disease (ELD) patients. However, important issues may hamper the early post-LT period (e.g. graft dysfunctions, infectious complications).
- Trial name
- NCT03666312
- Where
- 3 sites in Italy
- Volunteers
- 275 people
- Sponsor
- Nicasio Mancini
Hepatocellular Carcinoma, Hepatoma
HepATocellular Cancer Hcv Therapy Study
Subjects with Hepatitis C Virus (HCV) infection, genotype 1 or 4 and with hepatocellular carcinoma (HCC) and a complete response to HCC therapy will be randomised to immediate or delayed (6 months) HCV therapy with Elbasvir…
- Conditions
- Hepatocellular Carcinoma, Hepatoma, Liver Cell Carcinoma, Hepatitis C
- Trial name
- HATCHeT (NCT04546802)
- Testing
- Elbasvir / Grazoprevir Oral Tablet
- Sponsor
- Bayside Health
Colorectal Cancer, Liver Metastasis
Liver Transplantation for Colorectal Cancer
This is an observational study that will follow adults with stage IV colorectal cancer whose disease has spread only to the liver (not to other organs) and who are undergoing a liver transplant as part of their cancer treatment.
- Trial name
- NCT07884110
- Testing
- Liver transplantation
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Pontificia Universidad Catolica de Chile
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