Clinical trials: Transplant, Liver
Liver Transplantation
The Effect of Exercises on Pain and Kinesiophobia in Transplant Patients
Liver transplantation is a treatment method used in acute and chronic liver failure. Progressive Relaxation Exercises, which are non-pharmacological methods aimed at minimizing complications and improving the quality of life…
- Trial name
- NCT06085599
- Testing
- Progressive relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Gurkan KAPIKIRAN
End Stage Liver Disease
Procurement of Leukapheresis Products From End Stage Liver Disease (ESLD) Patients for Immunological Studies
Regulatory CD4+CD25+ T cells (Treg) derived from the thymus and/or periphery can control immune responsiveness to auto- and allo-antigens.
- Trial name
- NCT02447926
- Testing
- Leukapheresis
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Liver Cancer, Tumor Recurrence
HOPE to Reduce Tumour Recurrence After LT In Patients With HCC
Hypothermic oxygenated ex-situ machine perfusion (HOPE) is a dynamic preservation method that has been developed to reduce the incidence and severity of ischaemia-reperfusion injury and to improve outcomes after liver…
- Conditions
- Liver Cancer, Tumor Recurrence, Hepatocellular Carcinoma, Liver Transplantation
- Trial name
- POTERE (NCT05876052)
- Testing
- Hypothermic oxygenated Perfusion - HOPE
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- University of Bologna
Lymphopenia
Persistent Lymphopenia in Liver Transplantation and Its Molecular Insights for Hepatocellular Carcinoma
A total of 145 Liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) were retrospectively enrolled at Kaohsiung Chang Gung Memorial Hospital between 2006 and 2019.
- Trial name
- NCT06368349
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Liver Failure
Hepatocyte Microbeads for Acute Liver Failure
Acute Liver Failure in children is associated with high mortality without liver transplantation. In addition, donor organ shortage makes it difficult to provide this treatment to every potential patient.
- Trial name
- HELP (NCT05491135)
- Testing
- HMB002
- Volunteers
- 17 people
- Sponsor
- King's College Hospital NHS Trust
Liver Transplant, Hemorrhage, Surgical
Platelet Count and Function After Usage of Two Different Cell Saver Devices During Liver Transplant Surgery
Intraoperative cell salvage is commonly used in surgeries that carry a major hemorrhagic risk to reduce the administration of allogeneic red blood cells and thus improve the outcome for the patient.
- Trial name
- PLFLTS (NCT06357455)
- Testing
- Cell Salvage Autotransfusion: SAME™ device, Cell Salvage Autotransfusion: Autolog™ device
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eduardo Schiffer
Hepatitis B, Cirrhosis
Phase III, Study to Evaluate the Efficacy of Two Different HBV Vaccination Schemes in Patients With Hepatic Cirrhosis
The objective of this clinical trial is to compare the response rate obtained with two different vaccination schemes against HBV in cirrhotic patients.
- Conditions
- Hepatitis B, Cirrhosis, Awaiting Organ Transplant
- Trial name
- NCT01884415
- Testing
- HBV vaccine
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Liver Transplantation, Hepatocellular Carcinoma (HCC)
Survival and Recurrence After ABO-Incompatible Living Donor Liver Transplantation for Hepatocellular Carcinoma
This retrospective cohort study aimed to evaluate long-term oncologic outcomes after ABO-incompatible living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC).
- Trial name
- HCC (NCT07703735)
- Volunteers
- 371 people
- Sponsor
- Seoung Hoon Kim
Colon Adenocarcinoma, Liver Metastasis Colon Cancer
LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis
This study is an interventional open label prospective study that aims to assess both overall and disease-free survival of patients treated with LDLT, partial or whole graft LT from deceased donors for unresectable CRLM.
- Trial name
- LIVERMORE (NCT05186116)
- Testing
- Living donor liver transplant, Split liver transplant, RAPID, DDLT
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Chronic HCV Infection
Ledipasvir/Sofosbuvir Fixed-Dose Combination Plus Ribavirin in Participants With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant
This study will evaluate ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) plus ribavirin (RBV) in participants with advanced liver disease or posttransplant and chronic genotype 1 or 4 hepatitis C virus (HCV)…
- Trial name
- NCT02010255
- Testing
- LDV/SOF, RBV
- Where
- 34 sites in Australia, Austria and 10 more
- Volunteers
- 334 people
- Sponsor
- Gilead Sciences
Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease
Positive Association of US-FLI With the Severity of CAD
As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD).
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease, SYNTAX Score, Ultrasonography
- Trial name
- NCT06541132
- Testing
- Observational study without human intervention
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Liver Transplant, Hepatocellular Carcinoma
Efficacy and Safety of Liver Transplantation for Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: a Single-arm, Multicenter, Prospective Study (HCC-BDTT in LT)
The prognosis for patients diagnosed with hepatocellular carcinoma with bile duct tumor thrombus (BDTT-HCC) remains notably grim, as there are presently no universally accepted treatment guidelines in place to address this…
- Conditions
- Liver Transplant, Hepatocellular Carcinoma, Bile Duct Tumor Thrombus
- Trial name
- NCT06928415
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Haemopoietic Stem Cell Transplantation, Allograft
Impact of a Fourth Hexavalent Vaccine After Hematopoietic Stem Cell Transplantation
It is recommended for patients who underwent an hematopoietic stem cell transplantation to receive 6 months after the graft 3 injections of hexavalent vaccine (diphteria-tetanus- poliomyelitis-pertussis-Hib-HBV) within 2 months…
- Trial name
- EVaxAll (NCT03402776)
- Testing
- 4th dose of hexavalent vaccine 1 month after the 3rd dose
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Liver Transplant Disorder, Sleep
The Effect Of Therapeutic Touch and Music Rest on Sleeping Applied to Children With Liver Transplantation
Today, the demand for liver transplantation is increasing day by day, since liver transplantation is considered the most effective treatment for end-stage liver disease.
- Trial name
- NCT05108636
- Testing
- Therapeutic Touch, Music Rest
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Maksude YILDIRIM
GI Disturbance
Myfortic Conversion Trial in OLT Recipients With GI Intolerance
Liver transplant patients often require multimodal immunosuppressive therapy to minimize their risk for rejection. In our regimen, MMF (mycophenolate mofetil) is often added to lower the side effects of the calcineurin…
- Trial name
- NCT00619216
- Testing
- Mycophenolic Acid (Myfortic)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of North Carolina, Chapel Hill
Focus : To Study the Differences in Patient Compliance to Immunosuppressive Treatments and Patient Preference.
Adherence to Immunosuppressive Therapy Liver Transplant Recipients
Immunosuppressive therapy is fundamental in post-liver transplant patients to prevent and reduce the incidence of acute cellular rejection. Non-compliance to treatment leading to graft rejection is a well-recognized event.
- Trial name
- AIM (NCT01959308)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Biliary Anastomotic Stenosis
Plastic Stenting Versus Retrievable Metallic Stenting for Biliary Anastomotic Stricture After Liver Transplantation
Liver transplantation is the best treatment option for patients with end-stage liver disease and early unresectable hepatocellular carcinoma.
- Trial name
- LT (NCT04144504)
- Testing
- Retrievable metallic stenting, Plastic stenting
- Where
- Hong Kong
- Volunteers
- 64 people
- Sponsor
- The University of Hong Kong
Liver Fibrosis After Liver Transplantation, Multiparameter Magnetic Resonance Imaging
Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation
It is an open label observation clinical trial, all participants are liver transplant patients. The investigators deem to make a better criteria for assessing liver fibrosis after liver transplantation.
- Trial name
- NCT05292885
- Testing
- Gadopentetate Dimeglumine Injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Alcoholic Hepatitis
Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis.
Alcoholic hepatitis (AH) is the most severe form of acute alcohol-related liver disease. Maddrey's discriminant function (mDF) >32 defines the severe form of AH, which is associated with a high mortality.
- Trial name
- AH2023 (NCT05883891)
- Testing
- prothrombin time
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatic Encephalopathy
Efficacy and Safety of Fecal Microbiota Transplant for Secondary Prophylaxis of Hepatic Encephalopathy
Despite standard of care, the recurrence of hepatic encephalopathy remains the primary cause for readmissions in individuals with cirrhosis.
- Trial name
- NCT05229289
- Testing
- Standard Medical Treatment, Fecal Microbiota Transplant
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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