Clinical trials: Transplant, Liver
Liver Transplantation, Low-weight Children
Outcomes of Liver Transplantation in Low Weight Children After Reducing the Lateral Segment of a Living Donor, Adapting the Shape and Size of the Graft to the Needs of the Recipient
The shortage of organs has always been a problem in pediatric liver transplants due to the lack of donors with an adequate size.
- Conditions
- Liver Transplantation, Low-weight Children, Hyper-reduced Liver Grafts
- Trial name
- NCT03594864
- Testing
- Liver transplantation with hyper-reduced grafts
- Where
- Argentina
- Volunteers
- 58 people
- Sponsor
- Hospital Italiano de Buenos Aires
Liver Transplantation, Pain Management
Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors
Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes.
- Trial name
- NCT07123740
- Testing
- Intrathecal Morphine, Bi-level Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Liver Transplantation, Living Donor
Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors
Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia…
- Conditions
- Liver Transplantation, Living Donor, Postoperative Pain
- Trial name
- NCT07233096
- Testing
- Rectus Intercostal Plane Block, Control (No Block)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
Vitamin D Deficiency, Hepatocellular Carcinoma
The Effect of Vitamin D Repletion in Patients With Hepatocellular Carcinoma on the Orthotopic Liver Transplant List
The purpose of this study is to investigate the effect of two different doses of vitamin D3 (2000 IU vs. 4000 IU) on serum 25-hydroxyvitamin D (25OHD) levels in patients with hepatocellular carcinoma on the liver transplant list.
- Trial name
- NCT01575717
- Testing
- Vitamin D3 4000 IU, Vitamin D3 2000 IU
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Andrea Branch
Liver Disease
Evaluation of EV1000™/volumeView™ for Cardiac Output Monitoring in Liver Transplantation
The investigators are trying to evaluate the agreement of cardiac output measurements taken using the specific thermistor-tipped arterial catheter ( the VolumeView ™ catheter) and the EV1000 ™ monitoring platform ( Edward…
- Trial name
- NCT02306018
- Testing
- EV1000™/volumeView™
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samsung Medical Center
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Myocardial Perfusion Imaging, Liver Failure
Myocardial Perfusion Imaging in Liver Transplantation Candidates
The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear.
- Trial name
- ExSPECT (NCT03864497)
- Testing
- Myocardial perfusion imaging
- Volunteers
- 403 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Liver Transplantation
To Evaluate the Efficacy and Safety of ADVAGRAF® After Treatment With a Tacrolimus in New Liver Transplant Recipients
This study's objective is to evaluate the incidence rate of acute rejection reactions after 24 weeks treatment with ADVAGRAF® following 3 months treatment with tacrolimus in new liver transplant recipients.
- Trial name
- NCT03423225
- Testing
- ADVAGRAF®
- Volunteers
- 31 people
- Sponsor
- Kim, Seoung-Hoon
MRI Scans
Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy
The overall goal of this research is to help develop a new magnetic resonance (MR) method, Quantitative Susceptibility Mapping (QSM), to improve the measurement of liver iron concentrations without the need for a liver biopsy.
- Trial name
- NCT04171635
- Testing
- Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI), R2* Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
End Stage Liver DIsease
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.
Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors).
- Trial name
- DCDNet (NCT04744389)
- Testing
- Hypothermic Machine Perfusion, Normothermic Machine Perfusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Liver Transplant; Complications, Neurologic Complication
Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation
Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation.
- Conditions
- Liver Transplant; Complications, Neurologic Complication, Postoperative Complications
- Trial name
- NCT04188717
- Volunteers
- 253 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplanatation
Remote Ischemic Preconditioning in Liver Transplantation
Remote (upper arm) ischemic preconditioning in the donor of living donor liver transplanta to ameliorate the effect of reperfusion injury in recipients.
- Trial name
- RIRI (NCT02534025)
- Testing
- Ischemia preconditioining
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Alcohol Related Liver Disease, Orthotopic Liver Transplantation
Risk and Protective Factors for Relapse to Alcohol Use in Patients With Liver Disease Undergoing Liver Transplantation
This is an observational, monocentric study, consisting of both a retrospective and a prospective component. The aim of the study is to identify risk and protective factors for alcohol relapse in patients with alcohol-related…
- Trial name
- NCT06749990
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
End Stage Liver DIsease
Adding Specialist Palliative Care to Transplantation Pilot Trial
Specialist palliative care has been shown to be beneficial for patients experiencing serious illness, but has not been studied for patients being evaluated for liver transplantation.
- Trial name
- ASPECT-Pilot (NCT05147935)
- Testing
- Palliative Care Consultation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Cirrhosis, Registered on Transplant List
Evaluation of Cirrhotic Cardiomyopathy by Cardiac MRI in Patients Waiting for Liver Transplant.
The aim of this multicenter prospective interventional pilot study is to describe the evolution of myocardial fibrosis in cirrhotic patients before and after liver transplantation (LT).
- Trial name
- CARDIOFIBROCIR (NCT06327308)
- Testing
- MRI, Blood sampling
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hepatocellular Carcinoma
Safety Study of NK Cells From Sibship to Treat the Recurrence of HCC After Liver Transplantation
The purpose of this study is to explore the safety of NK cells from Sibship in patients with recurrent hepatocellular carcinoma after liver transplantation.
- Trial name
- NCT02399735
- Testing
- Low Dose NK cells ×4 times, Normal Dose NK cells ×4 times, Normal Dose NK cells ×8 times
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Failure, Mesenchymal Stem Cells
Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantation
The study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after single transplantation with autologous marrow mesenchymal stem cells (MMSCs).
- Trial name
- NCT00956891
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Sun Yat-sen University
Liver Failure
Hepatocyte Transplantation in Liver Failure
The investigators research will examine the safety and efficacy of hepatocyte transplantation in the patient with acute liver failure without history of chronic disease.
- Trial name
- NCT00805610
- Testing
- Hepatocyte Transplantation
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Liver Transplant Infection
Evaluation of Procalcitonin (PCT) as a Marker of Infection Post Living Donated Liver Transplant
, the study aimed at assessing the frequency of rising procalcitonin associated with infectious complications in immunosuppressed LDLTRx.
- Trial name
- NCT03389360
- Testing
- procalcitonin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
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