Clinical trials: Transplant, Liver
Biliary Atresia, Fibrosis, Liver
Stem Cell Applications in Biliary Atresia Patients
Recently, mesenchymal stem cell (MSC) transplantation has emerged as a promising treatment for liver cirrhosis in adults. Additionally, bone marrow-derived stem cell transplantation has shown success in treating children with…
- Conditions
- Biliary Atresia, Fibrosis, Liver, Stem Cell
- Trial name
- NCT06564740
- Testing
- Stem Cell, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Necmi Kadıoğlu Hospital
End Stage Liver DIsease
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.
Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors).
- Trial name
- DCDNet (NCT04744389)
- Testing
- Hypothermic Machine Perfusion, Normothermic Machine Perfusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Alcoholic Liver Cirrhosis
Long-Term Follow-up of Patients With Alcoholic Liver Cirrhosis Treated With Cellgram-LC
The goal of this observational study is to learn about the long-term safety of Cellgram-LC in patients with alcoholic liver cirrhosis who previously received Cellgram-LC in the PMC-P-07 study.
- Trial name
- NCT05093881
- Where
- 14 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Pharmicell Co., Ltd.
Hemorrhage
TachoSil® Versus Surgicel® Original for the Secondary Treatment of Local Bleeding in Adult and Pediatric Patients Undergoing Hepatic Resection Surgery
The efficacy and safety of TachoSil® as secondary hemostatic treatment in hepatic resection surgery will be compared to the standard USA licensed hemostatic agent, Surgicel® Original.
- Trial name
- NCT01192022
- Testing
- TachoSil®, Surgicel® Original
- Where
- 17 sites in United States
- Volunteers
- 253 people
- Sponsor
- Takeda
Liver Transplantation
To Evaluate the Efficacy and Safety of ADVAGRAF® After Treatment With a Tacrolimus in New Liver Transplant Recipients
This study's objective is to evaluate the incidence rate of acute rejection reactions after 24 weeks treatment with ADVAGRAF® following 3 months treatment with tacrolimus in new liver transplant recipients.
- Trial name
- Assign (NCT04761731)
- Testing
- ADVAGRAF®
- Volunteers
- 31 people
- Sponsor
- Linical Korea
Evidence of Liver Transplantation
Cefepime Pharmacokinetics in Liver Transplant Recipients in an Intensive Care Unit
The purposes of this study are to: I. Characterize the plasma concentration-time profile of cefepime in liver transplant patients to determine the pharmacokinetic parameters in this patient population. II.
- Trial name
- NCT00177931
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Cirrhosis, Hepatocellular Carcinoma
Hepatocellular Carcinoma Growth and Molecular Aggressiveness
Our long-term objective is to develop a new tool based on a (molecular-biology) integrated imaging technology able to characterize and categorize hepatocellular carcinoma (HCC) patients in need of liver transplant (LT).
- Trial name
- UniRer (NCT01657695)
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Prof. Facchinetti Fabio
Liver Transplantation
Role of Human Leukocyte Antigen Matching in Liver Transplantation and Its Relation to Outcomes
The study aimed to assess HLA compatibility, HLA antibodies and cross matching in liver transplantation recipients and their relation to acute rejection, CMV infection, and recurrence of HCV.
- Trial name
- NCT03094728
- Testing
- HLA cross matching
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Liver Transplant; Complications
Lung Ultrasound as a Point of Care Test for Living Donor Liver Transplant Recipients.
Liver transplant is now a standard treatment for end-stage liver disease patients. Pulmonary complications are common in the perioperative period and are associated with adverse outcomes.
- Trial name
- NCT04413695
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatocellular Carcinoma, Portal Vein Tumor Thrombus
Lenvatinib Following Liver Transplantation in Patients of Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
The aim of this study is to observe the efficacy and safety of lenvatinib in preventing recurrence of hepatocellular carcinoma patients with portal vein tumor thrombus after liver transplantation.
- Conditions
- Hepatocellular Carcinoma, Portal Vein Tumor Thrombus, Liver Transplantation
- Trial name
- LLTHVV (NCT04319484)
- Testing
- lenvatinib
- Volunteers
- 108 people
- Sponsor
- RenJi Hospital
Hepatitis C
Outcomes in Hepatitis C After Living Donor Liver Transplantation in Association With Interleukin 28 B
Hepatitis C is the leading cause of liver transplants in the USA. Given that there is a national organ shortage, living donor liver transplantation has became a viable option for patients with end stage liver disease who are not…
- Trial name
- NCT01429155
- Testing
- Interleukin 28B genotype
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Henry Ford Health System
Liver Cancer
DEB-TACE Prior to Liver Transplantation in the Treatment of HCC
The goal of the study is to explore whether the usage of DEB-TACE (Drug-Eluting Bead Transarterial Chemoembolization) prior to living donor liver transplantation can prolong the recurrence-free survival in patients with…
- Trial name
- NCT06353126
- Testing
- DEB-TACE
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Liver Cirrhosis
Difference in Efficacy Between Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients
The current treatment methods of liver cirrhosis are limited ,including antiviral therapy,supportive therapy and liver transplantation.
- Trial name
- NCT01718587
- Testing
- stem cell transplantation through interventional procedure, antiviral therapy (lamivudine, other antiviral drugs)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Opioid Use, Auriculotherapy
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear.
- Conditions
- Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain
- Trial name
- NCT05506878
- Testing
- NSS-2 BRIDGE
- Where
- 4 sites in United States
- Volunteers
- 286 people
- Sponsor
- Jacques E. Chelly
Post Liver Transplant Infection
Effect of Preoperative Vitamin D Supplementation in Liver Transplant Recipients With Vitamin D Deficiency on Post Transplant Outcomes
Liver transplantation (LT) remains the ultimate option to cure intractable end stage liver disease. Vitamin D deficiency is very common in these subsets of patients.
- Trial name
- NCT06736093
- Testing
- Vitamin D3
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Non-Alcoholic Fatty Liver Disease, Renal Transplant Complication Pre-Existing Disease
Transient Elastograghy to Detect Non Alcoholic Fatty Liver Disease in Renal Transplantation Recipients.
a. Primary (main): The presence of non alcoholic fatty liver disease in post renal transplantation recipients by non invasive methods as transient elastograghy b-Secondary (subsidiary): to evaluate if transient elastograghy could…
- Trial name
- NCT05894993
- Testing
- transient elastograghy
- Volunteers
- 50 people
- Sponsor
- Amany Khaled Ali Ahmed
Liver Transplantation (LT)
Physical Activity and Quality of Life After Liver Paired Exchange Transplantation
This prospective longitudinal observational study evaluated changes in physical activity, cognitive function, functional exercise capacity, and health-related quality of life in adult recipients following liver paired exchange…
- Trial name
- NCT07863349
- Testing
- Post-Transplant Follow-up Assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- İlker DEMİR
Cirrhosis, Liver, End Stage Liver DIsease
Angiotensin 2 for AKI After OLT
Kidney injury is a common complication following liver transplantation and is associated with a higher complication rate and increased risk of death.
- Conditions
- Cirrhosis, Liver, End Stage Liver DIsease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- NCT04592744
- Testing
- Angiotensin II, Norepinephrine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Liver Disease, Liver Transplantation
Peripheral Immunologic Response of Solid Organ Transplant Recipients to Depletion Versus Non-depletion Protocols
Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune…
- Trial name
- NCT00839709
- Testing
- blood sampling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Hepatitis C, Chronic, Lung Transplant
Lung Transplantation in Chronic HCV Infection With Post Transplant EPCLUSA Treatment
The purpose of this study is to evaluate whether treatment with Epclusa (sofosbuvir/velpatasvir) after lung transplantation in individuals with chronic hepatitis C infection is feasible, safe and effective at curing HCV.
- Trial name
- NCT03207399
- Testing
- Epclusa
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
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