Clinical trials: Transplant, Liver
Chronic Pain, Liver Transplantation
Investigation of Pain Incidence After FK506 Immunosuppressive Therapy in Liver Transplantation Patients
FK506 (tacrolimus), a calcineurin inhibitor, is widely used as an immunosuppressant to lower the risk of organ rejection after organ transplantation, and to treat T cell-mediated diseases such as eczema and atopic dermatitis.
- Trial name
- NCT04559048
- Testing
- FK506
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Second Hospital of Tangshan
Cytomegalovirus Infection, Hepatitis C
Impact of Cytomegalovirus (CMV) Replication Over Hepatitis C Recurrence in Liver Transplant Recipients
The relationship between cytomegalovirus infection and recurrence of hepatitis C in liver transplant recipients remains controversial.
- Trial name
- VHENUS (NCT01473849)
- Where
- 13 sites in Spain
- Volunteers
- 179 people
- Sponsor
- Sociedad Española de Trasplante Hepático
Hepatitis C Virus Infection
Sofosbuvir/Velpatasvir Fixed-Dose Combination in HCV-Infected Adults Who Are Undergoing Liver Transplantation
The primary objectives of this study are to evaluate the antiviral efficacy, safety, and tolerability of sofosbuvir/velpatasvir (SOF/VEL) fixed-dose combination (FDC) in hepatitis C virus (HCV)-infected adults who are undergoing…
- Trial name
- NCT02728206
- Testing
- SOF/VEL
- Where
- New Zealand
- Volunteers
- 9 people
- Sponsor
- Gilead Sciences
Transplant; Failure, Liver
Rapid Assessment of Donor Liver Quality
Aims： 1. Conduct multi-center, prospective and open research on liver quality assessment and establish LSCM liver quality assessment system 2.
- Trial name
- NCT03647059
- Testing
- LSCM examination
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
HIV Infection, Liver Transplant
Expanding HOPE Liver
This is a prospective, multicenter clinical study. The objective is to determine whether a liver transplant from a deceased donor with HIV is associated with an increased risk of opportunistic infection and cancer.
- Trial name
- NCT07778459
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hepatitis C, Evidence of Liver Transplantation
Switch From Tacrolimus to Cyclosporin in the Treatment of Recurrent Hepatitis C After Liver Transplantation
In France, 50% of hepatitis C virus carriers develop chronic clinical hepatitis, which may lead to cirrhosis and liver transplantation.
- Trial name
- NCT00375895
- Testing
- ciclosporin
- Where
- 13 sites in France
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital
Chronic Hepatitis b
Study on Effect of Intestinal Microbiota Transplantation in Chronic Hepatitis B
Chronic hepatitis B(CHB) is a common infectious disease affecting up to 2 billion people worldwide. Around 650 thousand people died of liver failure, cirrhosis and primary liver cancer caused by chronic hepatitis B every year.
- Trial name
- CHB (NCT03429439)
- Testing
- intestinal microbiota transplant, Antiviral Agents
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongshan Hospital Xiamen University
Fungemia, Mycoses
Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients
The aim of the study is to determine viable use of caspofungin in post-OLTx patients, and to demonstrate in particular the effectiveness, understood as the ability to reduce the incidence of invasive fungal infections, and to…
- Trial name
- CPHRLTX (NCT01260974)
- Testing
- Caspofungin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Ospedaliera di Padova
Hepatitis B
A Study to Investigate the Safety and Efficacy of Undiluted Intravenous Infusion of I.V.-Hepabig Inj.
The purpose of this study is to evaluate the efficacy and safety of undiluted intravenous infusion of I.V.-Hepabig inj. in post-liver transplant patients
- Trial name
- NCT05686759
- Testing
- Undiluted I.V.-Hepabig inj(GC5103), Diluted I.V.-Hepabig inj(GC5103)
- Where
- 8 sites in South Korea
- Volunteers
- 105 people
- Sponsor
- GC Biopharma Corp
Liver Transplant
Liver Transplantation With Tregs at MGH
This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.
- Trial name
- LITTMUS-MGH (NCT03577431)
- Testing
- arTreg-CSB, leukapheresis, cyclophosphamide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
End Stage Liver DIsease, Liver Failure
VitaSmart HOPE System: Bridge to HOPE Registry
This is a post-market, multicenter, single-arm, observational registry evaluating real-world use of the VitaSmart HOPE System under standard of care conditions.
- Trial name
- NCT07578441
- Testing
- hypothermic oxygenated perfusion therapy of a donor liver under standard of care conditions
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Bridge to Life Ltd.
Kidney Disease, Liver Transplantation
Evaluation of Kidney Disease in Liver Transplant Recipients
A non-invasive urinary test that detects kidney injuries in liver transplant (LT) candidates would be useful for monitoring of kidney damage.
- Trial name
- NCT00585429
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Hepatitis C Viral Infection
Early Treatment With Sofosbuvir (SOF) and Ledipasvir (LDV) to Prevent HCV Recurrence After Liver Transplantation (OLT)
The study is a single centre, single arm, open-label, proof of concept study enrolling 20 adult primary liver transplant recipients with genotype 1 HCV infection.
- Trial name
- NCT02478229
- Testing
- Sofosbuvir (SOF) and Ledipasvir (LDV)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Hepatitis C, Heart Transplant
Expanding the Pool in Orthotopic Heart Transplantation
This is an open-label, pilot trial to test the safety and efficacy of transplantation of hearts from HCV seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on…
- Conditions
- Hepatitis C, Heart Transplant, Cardiac Transplant
- Trial name
- NCT03222531
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mary E. Keebler, MD
Cirrhosis, Liver
The Establishment of Multiple Point Prediction Model About Tacrolimus Metabolic Differences Based on Genetic Network After Liver Transplantation and the Application of Multicenter
Combined with the clinical data of FK506 and the database of GO and Kyoto Encyclopedia of Genes and Genomes（KEGG）, the investigators aim to carry out the bioinformatic analysis and build a muti-locus genetic model, then…
- Trial name
- NCT02752529
- Testing
- Tacrolimus（FK506）
- Where
- China
- Volunteers
- 415 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Liver Transplant; Complications, Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient
Ischemia and reperfusion injury is unavoidable during a liver transplantation. Remote ischemic preconditioning, a safe and feasible method, has previously been shown to reduce ischemia and reperfusion injury.
- Trial name
- NCT03758352
- Testing
- remote ischemic preconditioning (rIC), non remote ischemic preconditioning (non-rIC)
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Renal Failure, Hyponatremia
Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation
The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis, hemorrhage, hepatic encephalopathy and hyponatremia) in patients with…
- Conditions
- Renal Failure, Hyponatremia, Sepsis, Hepatic Encephalopathy
- Trial name
- MACHT (NCT00839358)
- Testing
- albumin, Midodrine
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplant Recipients, Liver Transplantation
Discovery and Validation of Proteogenomic Biomarker Panels in Liver Transplant Recipients
The main focus of this study is to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had a liver transplant.
- Trial name
- PROGENI-LI (NCT01672164)
- Where
- 6 sites in United States
- Volunteers
- 202 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dyslipidemias, Hyperlipidemias
Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients
To study the efficacy and safety of pitavastatin and PCSK9 inhibitors in liver transplant patients on ongoing immunosuppressive therapy.
- Conditions
- Dyslipidemias, Hyperlipidemias, Liver Transplant Disorder, Immunosuppression
- Trial name
- PINTL (NCT05537948)
- Testing
- Pitavastatin, PCSK9 inhibitor
- Where
- Russia
- Volunteers
- 59 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Liver Transplantation, Clinical Registry
Institutional Registry of Liver Transplantation
The Institutional Registry of Liver Transplantation is a system for data collection related to patients with liver disease who are possible candidates for liver transplantion.
- Trial name
- IRLT (NCT02839616)
- Testing
- orthotopic liver transplantation
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Hospital El Cruce
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