Clinical trials: Transplant; Failure, Kidney
Chronic Kidney Disease, Diabetes
Improving Chronic Disease Management With Pieces
ICD-Pieces (Parkland Intelligent e-Coordination and Evaluation System) trial is a National Institutes of Health (NIH) Healthcare Systems(HCS) Collaboratory demonstration project to improve management of patients with a triad of…
- Conditions
- Chronic Kidney Disease, Diabetes, Hypertension, High BP
- Trial name
- ICD-Pieces (NCT02587936)
- Testing
- Collaborative Model of Primary care and Subspecialty care
- Where
- 4 sites in United States
- Volunteers
- 18,268 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Kidney Disease stage3
Effect of Intradialytic Exercises in Chronic Kidney Disease Patients
the purpose of this study is to compare between intradialytic aerobic versus resistive exercises on immunity response in patients with chronic kidney disease.
- Trial name
- NCT06293092
- Testing
- leg pedaling cycling device, sand bags, hemodialysis sessions
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Renal Insufficiency
Evaluation of ESPAIR, an Educational Therapy's Program of Patients With Renal Insufficiency Before Kidney Transplant
Treatment care of end-stage renal insufficiency is an important public health issue. The balance between patients waiting for a kidney transplant and available graft raises questions.
- Trial name
- ESPAIR (NCT02468440)
- Testing
- ESPAIR
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Toulouse
Kidney Transplantation, Chronic Kidney Failure
Early Conversion From Tacrolimus to Efalizumab Maintenance Therapy in Kidney Transplant Recipients
The toxicity of calcineurin inhibitors(CNI)is a major factor limiting the success of renal transplantation. This protocol aims to replace the calcineurin inhibitor, tacrolimus, with efalizumab early after transplantation in…
- Trial name
- NCT00472082
- Testing
- efalizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Emory University
Kidney Failure, Chronic, Covid19
Assessment of Immune Response After Vaccination Against COVID-19 in Patients Treated With Renal Replacement Therapy
Chronically dialyzed patients and kidney transplant recipients have been identified as particularly vulnerable to SARS-CoV-2 infection due to unavoidable exposure.
- Conditions
- Kidney Failure, Chronic, Covid19, Vaccine Reaction, Vaccine Adverse Reaction
- Trial name
- COViNEPH-1 (NCT04905862)
- Testing
- Immune response, Solicited common and expected adverse reactions shortly following vaccination (reactogenicity), use of antipyretic or pain medications and unsolicited adverse events and serious adverse events
- Where
- 4 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
Atrial Fibrillation, Acute Kidney Injury
Autonomic State, Cardiovascular Control and Outcomes in Coronary Surgery
Characterization of the perioperative autonomic nervous system state, cardiovascular and cerebrovascular control and microcirculation in order to predict postoperative atrial fibrillation and acute kidney injury in patients…
- Trial name
- NCT03169608
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Transplant Failure
Pilot Study: Interest of Belatacept as a Non-nephrotoxic Immunosuppressive Treatment in Cardiac Transplant Patients at Risk of Chronic Renal Failure (BELACOEUR)
Heart transplantation (TC) is the standard treatment for terminal heart failure. Chronic kidney disease (CKD) is a common complication responsible for increased mortality and morbidity.
- Trial name
- BELACOEUR (NCT04180085)
- Testing
- Belatacept Injection
- Where
- 4 sites in France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Lung Transplant; Complications
Trial Comparing Immediate Versus Extended Release Tacrolimus; Reducing Calcineurin Inhibitor Related Toxicity in Lung Transplantation Patients
Lung transplantation is a life-saving option in patients with end-stage lung disease. The introduction of calcineurin inhibitors has significantly improved long-term outcome in lung transplantation.
- Trial name
- REVOLUTION (NCT05001074)
- Testing
- Extended release tacrolimus, Immediate release tacrolimus
- Where
- Netherlands
- Volunteers
- 145 people
- Sponsor
- Heleen Grootjans
Kidney Diseases, Chronic Kidney Diseases
NAVIGATE Kidney: A Multi-level Intervention to Reduce Kidney Health Disparities
The overarching goal of this project is to refine and adapt previous work on the NAVIGATE-Kidney project for individuals with CKD.
- Trial name
- NAV-Kidney (NCT06810622)
- Testing
- Community health worker intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 448 people
- Sponsor
- University of Colorado, Denver
Multiple Myeloma, End Stage Renal Disease
Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)
The primary objective is to cure multiple myeloma with less toxic allogeneic bone marrow transplantation while inducing renal allograft tolerance through mixed chimerism in patients with end stage renal failure and multiple…
- Trial name
- NCT00854139
- Testing
- Cyclophosphamide, anti-thymocyte globulin, Kidney transplant, Thymic irradiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
End Stage Renal Disease, Antibody Mediated Rejection
Belatacept in Kidney Transplantation of Moderately Sensitized Patients
The purpose of this study is to evaluate the safety and effectiveness of an immunosuppressive medication, Belatacept, as a replacement for a calcineurin inhibitor, in combination with a standard of care regimen of…
- Trial name
- BelatPilot (NCT02130817)
- Testing
- Belatacept, Tacrolimus withdrawal, Plasmapheresis/Intravenous Immunoglobulin G
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Kidney Transplant Failure, Chronic Kidney Failure
Normothermic Machine Perfusion: an Additional Value for Kidney Transplant Outcomes?
This study is a randomised, controlled, phase II trial to assess the efficacy of 2 hours normothermic machine perfusion (NMP) of extended criteria(EC)-DBD (donation after brain death) and DCD (donation after circulatory death)…
- Trial name
- APOLLO (NCT04882254)
- Testing
- Normothermic machine perfusion
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
Cancer
Antithymocyte Globulin, Clofarabine, and Rituximab in Treating Patients After an Unsuccessful Stem Cell Transplant
RATIONALE: Antithymocyte globulin, clofarabine, and rituximab may stop the patient's immune system from rejecting the donor's stem cells when they do not exactly match the patient's blood.
- Trial name
- NCT00617929
- Testing
- anti-thymocyte globulin, rituximab, clofarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Kidney Diseases, End Stage Renal Disease
Ixazomib for Desensitization
The purpose of this research study is to find out how well ixazomib (the study drug) works to desensitize highly sensitized kidney transplant recipients.
- Trial name
- IXADES (NCT03213158)
- Testing
- Ixazomib Oral Capsule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Renal Failure, Hyponatremia
Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation
The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis, hemorrhage, hepatic encephalopathy and hyponatremia) in patients with…
- Conditions
- Renal Failure, Hyponatremia, Sepsis, Hepatic Encephalopathy
- Trial name
- MACHT (NCT00839358)
- Testing
- albumin, Midodrine
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Hospital Clinic of Barcelona
End Stage Renal Disease
Rituximab Desensitization Therapy for Patients on the Waiting List for Kidney Transplant
This is a study of patients who have a high risk of kidney rejection before kidney transplant. The hypothesis is that treatment with a medication called rituximab will make it possible for them to receive a kidney transplant from…
- Trial name
- NCT00167791
- Testing
- rituximab
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Kidney Failure, Chronic
MIC Cell Therapy for Individualized Immunosuppression in Living Donor Kidney Transplant Recipients
A phase- I clinical trial to determine safety and feasibilty of intravenous administration of mitomycin C-treated donor peripheral blood mononuclear cells in patients with chronic kidney disease stage KDIGO 4 or 5 (i.e.
- Trial name
- TOL-1 (NCT02560220)
- Testing
- Mitomycin C-induced peripheral blood mononuclear cells (MICs)
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Heidelberg University
Kidney Transplant, Renal Transplant Failure
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage.
- Conditions
- Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty
- Trial name
- HLA-AB (NCT06025240)
- Testing
- cf-DNA, Immunological Events following renal transplant in older age, Determining Predictive Models for Post-transplant HLA-specific Antibody Formation
- Where
- United Kingdom
- Volunteers
- 282 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
End Stage Renal Disease
Evaluation of the GORE® ACUSEAL Vascular Graft for Hemodialysis Access
This study is a prospective, non-randomized, multi-center evaluation of the performance of the GORE® ACUSEAL Vascular Graft. The study will enroll patients with End-Stage Renal Disease (ESRD), who are either currently receiving…
- Trial name
- ACUSEAL (NCT01173718)
- Testing
- GORE® ACUSEAL Vascular Graft
- Volunteers
- 138 people
- Sponsor
- W.L.Gore & Associates
Arteriovenous Graft, Arteriovenous Fistula
Validation of Arterio Venous Access Stage (AVAS) Classification
VAVASC trial is an observational multicentre study. The aim of this trial is to validate AVAS (arteriovenous vascular access stage) classification.
- Conditions
- Arteriovenous Graft, Arteriovenous Fistula, Dialysis Access Malfunction, Kidney Failure
- Trial name
- VAVASC (NCT04796558)
- Testing
- AVAS Classification
- Where
- Czechia
- Volunteers
- 800 people
- Sponsor
- Vascular surgery, University hospital Královské Vinohrady, Prague