Clinical trials: Transplant Complication
Renal Transplantation
Systematic Transplantectomy Versus Conventional Care After Kidney Graft Failure
Our hypothesis is early and systematic transplantectomy under a well-conducted immunosuppression is associated with a decreased risk of anti-HLA immunization against a conservative attitude including a gradual reduction of…
- Trial name
- DESYRE (NCT01817504)
- Testing
- Systematic transplantectomy, Progressive reduction of immunosuppression
- Where
- 9 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant
This phase I/II trial studies whether stopping cyclosporine before mycophenolate mofetil is better at reducing the risk of life-threatening graft-versus-host disease (GVHD) than the previous approach where mycophenolate mofetil…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00078858
- Testing
- fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 37 people
- Sponsor
- Fred Hutchinson Cancer Center
Alveolar Bone Resorption, Graft Overgrowth
Histological and Volumetric Evaluation of Customized Allograft Bone Blocks
Customized bone blocks need CBCT and digital software to design the block needed to rehabilitate. Some advantages are reduced surgical time and better adaptation of the graft, leading to less complications.
- Conditions
- Alveolar Bone Resorption, Graft Overgrowth, Resorption of Bone Graft, Graft Complication
- Trial name
- NCT05937035
- Testing
- Customized allogenic bone block surgery
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Acute Kidney Injury, Ischemia Reperfusion Injury
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients
The purpose of this study is to find out if a drug called valproic acid (VPA) will protect organs (like the kidneys) from harmful effects caused by the temporary drop and then rise of blood flow and oxygen (called ischemia…
- Trial name
- NCT04531592
- Testing
- Valproic acid, Isotonic saline solution
- Where
- 4 sites in United States
- Sponsor
- Westat
Leukemia, Acute Lymphocytic (ALL), Leukemia, Myeloid, Acute(AML)
Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies
Blood and marrow stem cell transplant has improved the outcome for patients with high-risk hematologic malignancies. However, most patients do not have an appropriate HLA (immune type) matched sibling donor available and/or are…
- Conditions
- Leukemia, Acute Lymphocytic (ALL), Leukemia, Myeloid, Acute(AML), Leukemia, Myeloid, Chronic(CML), Juvenile Myelomonocytic Leukemia (JMML)
- Trial name
- NCT00566696
- Testing
- CliniMACS, Stem cell transplantation, Fludarabine
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- St. Jude Children's Research Hospital
Cancer, Leukemia
C-Reactive Protein as a Predictor of Stem Cell Transplant Complications
The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.
- Conditions
- Cancer, Leukemia, Stem Cell Transplantation
- Trial name
- NCT00179868
- Testing
- C-Reactive Protein levels
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Chronic Kidney Disease
Development and Effects of a Structural Education Program in Adult Kidney Transplant Recipients
Kidney transplantation is the treatment of choice for patients with end-stage renal disease. The purpose of this randomized and controlled study is to evaluate the efficacy of a structured education program for adult kidney…
- Trial name
- NCT01630824
- Testing
- Structured education program
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University of Jena
Graft Failure, Donor Site Complication
Arthroscopic Superior Capsular Reconstruction With Fascia Lata Autograft - Survivorship of the Autograft Analysis
An irreparable rotator cuff tear (IRCT) is a challenge, with a controversial definition and different treatment options. None of the latter are exempt of limitations and their survivorship is one of the concerns.
- Conditions
- Graft Failure, Donor Site Complication, Rotator Cuff Tear
- Trial name
- NCT03663036
- Testing
- Magnetic Resonance Imaging of the shoulder
- Where
- Portugal
- Volunteers
- 21 people
- Sponsor
- Clara Isabel de Campos Azevedo
Skin Graft Wounds, Donor Site Complication
Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites
The goal of this clinical trial is to learn if Aloe Vera gel dressing helps reduce pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adult patients aged 18 to 60.
- Conditions
- Skin Graft Wounds, Donor Site Complication, Pain, Postoperative, Skin Transplantation
- Trial name
- AloePaTu (NCT07057557)
- Testing
- Aloe Vera Gel Dressing, Paraffin-Based Tulle Dressing
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- King Edward Medical University
Cancer
High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill…
- Trial name
- NCT00002854
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- City of Hope Medical Center
Disorder Related to Renal Transplantation
Orientation of the Lymphocyte Response to the Occurrence of Atherosclerotic Complications After Kidney Transplantation
The incidence of atherosclerotic complications is increased after kidney transplantation. Traditional risk factors do not fully explain this increased risk.
- Trial name
- ORLY-Est (NCT02843867)
- Testing
- blood sample
- Where
- 7 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Kidney Transplant, Complications
PGDT in Patients Undergoing Kidney Transplant
This study is a multicentric randomized controlled trial comparing two groups of patients undergoing single or dual kidney transplantation from deceased donors.
- Trial name
- PGDT (NCT05035537)
- Testing
- PGDT
- Where
- 2 sites in Italy
- Volunteers
- 181 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Healthy, Lupus
Direct to Patient Minimal Risk Biospecimen and Data Collection Research
This study aims to help researchers better understand health conditions and develop improved tests, treatments, and cures for diseases.
- Conditions
- Healthy, Lupus, Celiac, Kidney Disease
- Trial name
- JBMR (NCT07128966)
- Testing
- Observation
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Joined Bio
Lung Transplant; Complications, Extracorporeal Circulation; Complications
Routine Versus Selective Intraoperative ECMO in Lung Transplant
Intraoperative hemodynamic management is vital in the success of lung transplantation. Significant intraoperative hemodynamic compromise and hypoxic episodes may contribute to an increase in severe postoperative complications…
- Conditions
- Lung Transplant; Complications, Extracorporeal Circulation; Complications, Postoperative Complications
- Trial name
- NCT05505422
- Testing
- Routine ECMO, On demand ECMO
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Kidney Disease, Proteinuria
Angiotensin II Blockade for Chronic Allograft Nephropathy
Chronic allograft nephropathy continues to be a major cause of kidney transplant loss and return to dialysis. Treatment options are limited and the course of the disease tends to be progressive.
- Trial name
- NCT00067990
- Testing
- Losartan 100mg
- Where
- 2 sites in United States
- Volunteers
- 153 people
- Sponsor
- University of Minnesota
Renal Dysfunction, Acute Renal Failure
Prevention Of Nephrotoxicity Following Bone Marrow Transplantation Using Urodilatin and Mannitol
The purpose of the study is to combine Urodilatin (ANP analogue), which will increase glomerular filtration rate (GFR), and mannitol, which will increase the rate of urinary flow and solute excretion.
- Conditions
- Renal Dysfunction, Acute Renal Failure, Mortality
- Trial name
- NCT00390624
- Testing
- URODILATIN (ULARITIDE, ATRIAL NATRIURETIC PEPTIDE), MANNITOL
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rocky Mountain Cancer Centers
Liver Transplant, Hemorrhage, Surgical
Platelet Count and Function After Usage of Two Different Cell Saver Devices During Liver Transplant Surgery
Intraoperative cell salvage is commonly used in surgeries that carry a major hemorrhagic risk to reduce the administration of allogeneic red blood cells and thus improve the outcome for the patient.
- Trial name
- PLFLTS (NCT06357455)
- Testing
- Cell Salvage Autotransfusion: SAME™ device, Cell Salvage Autotransfusion: Autolog™ device
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eduardo Schiffer
Hyperalgesia, Pain
Local Anesthetic Infusion and Sternotomy
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy.
- Trial name
- CARDIODOLAL (NCT00802048)
- Testing
- Local anesthetic (Ropivacaine), Saline
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Transplantation, Acute Renal Failure
Metabolic Pattern of Cyclosporine A and Acute Renal Failure
Following heart transplantation many patients develop acute renal failure in the early posttransplant phase and some are in need of renal replacement therapy for shorter or longer time.
- Trial name
- NCT00264355
- Testing
- cyclosporine A
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo School of Pharmacy