Clinical trials: Transplant Donation
Stem Cell Donors
Impact of Stem Cell Donation on Unrelated and Related Donors' Health.
Haematopoietic stem cell donation represents a unique chance for curing patients affected with onchohaematologic and inherited diseases.If a related donor is unavailable a unrelated donor must be used.
- Trial name
- HPCDON (NCT06905704)
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Organ Transplant
DCD IIT: Evaluating the Safety of Utilizing Donor Hearts From Donation After Circulatory Death (DCD) Donors
The purpose the research is to evaluate whether patients who receive a Donation after Circulatory Death (DCD) heart for cardiac transplantation using either normothermic regional perfusion (NRP) or direct procurement and…
- Trial name
- NCT05462041
- Testing
- DBD Donor Heart Transplantation, DCD Donor Heart Transplantation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Liver Transplantation
Immunometabolism of Machine Perfusion Strategies
There are not enough donated livers for everybody who needs one, and as a result, thousands of patients worldwide are waiting for liver transplants, with many dying while waiting for a life-saving organ.
- Trial name
- iMaps (NCT06371924)
- Testing
- Machine Perfusion
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College Hospital NHS Trust
Liver Diseases, Kidney Diseases
Hypothermic Oxygenated Perfusion Versus Static Cold Storage for Marginal Graft
One of the major challenge in the field of organ transplantation is the shortage of donor organs. Many patients waiting for organ transplantation die during the waiting time and many patients wait for organ transplantation many…
- Trial name
- PIO (NCT03031067)
- Testing
- Machine perfusion
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Matteo Ravaioli
Hematopoietic/Lymphoid Cancer
Hematopoietic Stem Cell Transplantation and Childhood Leukemia Quality of Life in SIbling DONors
The childhood cancer experience necessarily impacts the entire family. In this context, particular attention should be paid to the donor siblings of hematopoietic stem cells in the context of treatment of leukemia by grafting.
- Trial name
- SIDONY (NCT03659071)
- Testing
- questionnaire VSP-A
- Where
- France
- Volunteers
- 1,187 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Kidney Transplant, Renal Transplant
Trial to Define the Benefits and Harms of Deceased Donor Kidney Procurement Biopsies
The purpose of this research study is to compare the impact of the availability of biopsy results at the time of organ offers on the use and outcomes of kidneys from deceased donors.
- Trial name
- NCT03837522
- Testing
- Procurement Biopsy: Frozen section, Procurement Biopsy: Permanent section
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- St. Louis University
Delayed Function of Renal Transplant
Efficacy and Safety of SANGUINATE™ for Reduction of Delayed Graft Function in Patients Receiving a Kidney Transplant
Safety and efficacy study of SANGUINATE on reduction of delayed graft function (DGF) in patients who will be recipients of a donation after brain death (DBD) donor kidney.
- Trial name
- NCT02490202
- Testing
- SANGUINATE, Normal Saline
- Where
- 20 sites in United States
- Volunteers
- 60 people
- Sponsor
- Prolong Pharmaceuticals
Heart Failure
Heart Transplantation Using Normothermic Regional Perfusion Donation After Circulatory Death
Normothermic regional perfusion (NRP) utilizes Extracorporeal Membrane Oxygenation (ECMO) or cardiopulmonary bypass to reperfuse the heart and other organs in situ after isolation and ligation of the cerebral vessels.
- Trial name
- NCT04284319
- Testing
- DCD Heart Transplantation Using NRP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Organ Donation
Donation Advisor Clinical Decision Support Tool Study
Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available.
- Trial name
- NCT04661787
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Hospital Research Institute
Organ Donation
Characterization of Opposition to Organ Donation at Strasbourg University Hospital in 2024-2025
In 2024, 29,000 people are waiting for organ transplants in France, and only 6,034 transplants were performed during the year. 852 people died while waiting for a transplant.
- Trial name
- OPPO-PMO (NCT07345975)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Transplantation
Enhancing Kidney Donation Through Live Organ Video Educated Donors (LOVED) Study Phase
LOVED stands for the Living Organ Video Educated Donors (LOVED) program. It is a culturally tailored program for African Americans to reduce the disparity of low rates of living kidney donation.
- Trial name
- LOVED (NCT03599102)
- Testing
- LOVED Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Kidney Transplantation
Donor Recipient Kidney Function Following Open Surgical vs. Laparoscopic Kidney Donation
This study will evaluate the differences between open surgical kidney donation and laparoscopic kidney donation on kidney donors and recipients.
- Trial name
- NCT00100516
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kidney Transplant, DCD Kidney
NRP + ex Situ HMPO2 vs NRP Alone in DCD Kidney Transplantation
The goal of this clinical trial is to learn if the combination of Normothermic Regional Perfusion (NRP) at the time of organ procurement with ex situ Hypothermic Oxygenated Perfusion (HMPO2) of kidneys recovered from donors after…
- Trial name
- OxyPerf (NCT07779187)
- Testing
- Ex situ hypothermic oxygenated machine preservation
- Where
- 3 sites in Sweden
- Volunteers
- 214 people
- Sponsor
- Karolinska University Hospital
Kidney Disease
Transplant Social Worker Support for Live Kidney Donation in African Americans
Talking About Live Kidney Donation Support (TALKS) will study the effectiveness of education, behavior, and financial support interventions to improve consideration of live kidney transplantation/live kidney donation among…
- Trial name
- TALKS (NCT02369354)
- Testing
- TALKS Social Worker Intervention, Financial Assistance Intervention
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
Hepatocellular Injury, Liver Transplant
HOPE for Human Extended Criteria and Donation After Brain Death Donor (ECD-DBD) Liver Allografts
The purpose of this study is to test the effects of hypothermic oxygenated machine perfusion (HOPE) in a phase-II prospective multicenter randomized clinical trial (RCT) on extended criteria donor allografts (ECD) in donation…
- Trial name
- HOPE-ECD-DBD (NCT03124641)
- Testing
- Hypothermic oxygenated perfusion (HOPE), Conventional cold storage (CCS)
- Where
- 4 sites in Czechia, Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital, Aachen
Kidney Diseases, Kidney Failure
Enhance Access to Kidney Transplantation and Living Kidney Donation
Compared to dialysis, kidney transplantation is associated with improved survival, better quality of life and substantial cost savings to healthcare systems.
- Conditions
- Kidney Diseases, Kidney Failure, End Stage Renal Disease
- Trial name
- EnAKT LKD (NCT03329521)
- Testing
- Multicomponent intervention
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Kidney Donation/Transplantation
"Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail
To compare the renal protective properties of two currently used anaesthetic techniques - a sevoflurane-remifentanil/sufentanil combination with a propofol-remifentanil/sufentanil combination for anaesthesia in patients…
- Trial name
- NCT01248871
- Testing
- procedure:sevoflurane-remifentanil/sufentanil, volatile agent only during reperfusion, propofol-remifentanil/sufentanil
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- University Medical Center Groningen
Liver Transplant Failure
Liver Graft Viability Assessment During Normothermic Regional Perfusion
With the increasing shortage of available donor organs, liver transplantation from donation after circulatory death (DCD) has been established in many countries to offer a therapeutic strategy for patients with end-stage liver…
- Trial name
- MAASTR3BOLOMIC (NCT05361044)
- Testing
- Blood samples Donnor
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Renal Insufficiency, Chronic
Multi-parametric MRI Evaluation of Renal Graft Performance After Living Donor Donation.
The selection of kidneys from living donors is based on strict glomerular filtration rate (GFR) values, in the setting of the increasing proportion of older donors.
- Trial name
- DOVIMIR (NCT06047106)
- Testing
- multiparametric MRI, kidney graft biopsy, blood samples
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Kidney Transplant
Clinical Outcome of Delayed or Standard Prograf Together With Induction Therapy Followed by Conversion to Advagraf in Donation After Cardiac (or Circulatory) Death (DCD) Kidney Transplant Recipients
The purpose of this study is to confirm non-inferiority of delayed Prograf treatment to standard Prograf treatment in the incidence of delayed graft function (DGF) within 1 week between the 2 immunosuppressive (IS) treatment…
- Trial name
- NCT03644485
- Testing
- Tacrolimus immediate-release formulation, Tacrolimus prolonged-release formulation, Induction therapy
- Where
- 14 sites in China
- Volunteers
- 284 people
- Sponsor
- Astellas Pharma China, Inc.