Clinical trials: Transplant Donation
Anal Carcinoma, Hematopoietic and Lymphoid Cell Neoplasm
Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers
This study collects blood and tissue samples for research of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)-related cancers.
- Conditions
- Anal Carcinoma, Hematopoietic and Lymphoid Cell Neoplasm, HIV Infection, Kaposi Sarcoma
- Trial name
- NCT05663502
- Testing
- Biospecimen Collection
- Where
- 8 sites in United States
- Volunteers
- 200 people
- Sponsor
- AIDS Malignancy Consortium
Kidney Diseases, Kidney Transplant Failure and Rejection
The Microbiota in Kidney Donation and Transplantation
The human gastrointestinal tract harbours ~40 trillion microbial cells, far outnumbering the cell number, and therefore the genetic content of its host.
- Conditions
- Kidney Diseases, Kidney Transplant Failure and Rejection, Urinary Tract Infections
- Trial name
- NCT04388930
- Testing
- Pre-operative assessment - blood, urine, & faecal sample, Post-operative day 3 assessment - blood, urine, & faecal sample, Post-operative week 4-6 assessment - blood, urine, & faecal sample
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Brain Death, Organ Donation
Deceased Organ Donor Interventions to Protect Kidney Graft Function
To protect kidney function during the transplantation process by comparing mild hypothermia in the deceased organ donor before organs are recovered and pulsatile perfusion of the kidney after recovery and prior to transplantation.
- Conditions
- Brain Death, Organ Donation, Organ Transplant Failure or Rejection, Delayed Graft Function
- Trial name
- NCT02525510
- Testing
- Pump Eligible - Normothermia - Pump Both Kidneys, Pump Eligible - Hypothermia and Pump Right Kidney, Pump Eligible - Hypothermia and Pump Left Kidney
- Where
- 7 sites in United States
- Volunteers
- 1,427 people
- Sponsor
- University of California, San Francisco
Liver Transplantation, Hepatocellular Carcinoma
Prognosis Analysis of Elderly Donor Liver in Liver Transplantation
Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering.
- Conditions
- Liver Transplantation, Hepatocellular Carcinoma, Survival
- Trial name
- NCT05355662
- Testing
- Age
- Volunteers
- 11,569 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Kidney Failure, Surgery
Effect of Lost Wage Reimbursement to Kidney Donors on Living Donation Rates
The study is designed as a randomized controlled trial. The investigators hypothesize that kidney transplant recipient candidates whose donors are offered reimbursement of lost wages (treatment arm) will have a higher probability…
- Conditions
- Kidney Failure, Surgery, Renal Failure
- Trial name
- NCT03350269
- Testing
- Information provision
- Where
- 6 sites in United States
- Volunteers
- 1,310 people
- Sponsor
- Arbor Research Collaborative for Health
Chronic Kidney Disease
Culturally Sensitive Behavioral Interventions to Enhance Living Kidney Donation / Living Kidney Transplantation
Title: Culturally tailored behavioral interventions to enhance living kidney donation/living kidney transplantation Applicants: Johns Hopkins Medical Institutions, National Kidney Foundation of Maryland Principal Investigator…
- Trial name
- TALK (NCT00932334)
- Testing
- TALK PLUS, TALK Standard, Usual Care
- Volunteers
- 145 people
- Sponsor
- Johns Hopkins University
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Kidney Transplant Donor
Modifiable Factors Affecting Racial Disparities in Kidney Donation
While many people offer to be evaluated at transplant centers as potential living donors to donate one kidney to someone they know, few ultimately donate. Racial/ethnic minorities are less likely to become living donors.
- Trial name
- NCT07793877
- Testing
- Not applicable- observational study
- Volunteers
- 2,332 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Transplant Recipient, Transplant Donation
University of Minnesota Transplant Registry
Under Transplant Information Services (TIS), the University of Minnesota Transplant Registry (UMTR) will serve as the repository for core research data.
- Trial name
- NCT01062581
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Minnesota
Reperfusion Injury, Hypothermic Oxygenated Machine Perfusion
Hypothermic Oxygenated Machine Perfusion of Extended Criteria Kidney Allografts From Brain Death Donors
Kidney transplantation (KT) has emerged as the mainstay of treatment for end-stage kidney disease. In an effort to address the widening gap between demand and supply of donor organs, there has been an increase in the numbers of…
- Trial name
- NCT03378817
- Testing
- HOPE, Conventional cold storage
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University Hospital, Aachen
Transplant Donation
Information-Assisted Intervention for Potential Living Kidney Donors
This study aims to evaluate the effectiveness of an information-assisted intervention in enhancing knowledge, decision self-efficacy, and reducing decisional conflict among potential living kidney donors.
- Trial name
- NCT07243717
- Testing
- Information-Assisted Intervention
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Hepatocellular Injury, Liver Transplant Disorder
Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation
The common practice of conventional cold storage (CCS) organ preservation has changed little since the initial introduction of the original University of Wisconsin (UW) organ preservation solution in the late 1980s.
- Trial name
- HOPE-NMP (NCT04644744)
- Testing
- Hypothermic oxygenated perfusion (HOPE), Normothermic machine perfusion (NMP)
- Where
- 4 sites in Germany
- Volunteers
- 213 people
- Sponsor
- Charite University, Berlin, Germany
Heart Transplantation, Perfusion
Heart Transplantation Utilizing NRP DCD
This is a prospective, observational, pilot trial to evaluate the feasibility of heart transplantation using normothermic regional perfusion (NRP) donation after donor circulatory death (DCD).
- Conditions
- Heart Transplantation, Perfusion, Transplant Recipients
- Trial name
- NCT05243914
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Arizona
Liver Transplant Disorder
Benefit of ESP Peri Operative Analgesia for Live Liver Donor Transplantation
Liver donors have a significant risk to develop persistent and chronic pain around 20 to 30% affecting social and professional life (17%) up to 1 year after the surgery.
- Trial name
- ESPLIVERDON (NCT04570969)
- Testing
- Erector spinae plane block
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- Vinmec Healthcare System
Liver Transplant; Complications, Ischemia Reperfusion Injury
Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation
The main purpose of this study is to increase the pool of organs available for donation by performing ARP to recondition donation after cardiac death (DCD) organs prior to transplantation.
- Conditions
- Liver Transplant; Complications, Ischemia Reperfusion Injury, Cirrhosis, Liver Cancer
- Trial name
- NCT03946852
- Testing
- Abdominal Regional Perfusion
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre
Living Kidney Donation
The Living Kidney Donor Safety Study
The main goal of this study is to understand the long-term effects of kidney donation on blood pressure, kidney function, and patient-reported health-related quality of life.
- Trial name
- LKD (NCT00936078)
- Where
- 13 sites in Australia, Canada
- Volunteers
- 1,438 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Renal Transplant
Characterization Of the Intestinal Microbiome Evolution After Kidney Transplant Donation or Receipt
This is a hypothesis-generating pilot study. The intent is to model the impact of perioperative practices on the intestinal microbiome and possibly associate these conditions with the final microbiome status (e.g., number of…
- Trial name
- COMET-DR (NCT03043339)
- Testing
- Stool Specimen Collection, Anal Swab Sampling, Short Diet Assessment (SDA)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
End-stage Kidney Disease
Optimizing Kidney Transplant Informed Consent
The objective of this study is to evaluate kidney transplant candidates' comprehension about increased risk donor kidneys necessary for informed consent.
- Trial name
- NCT01859884
- Testing
- Inform Me: web-based education tool
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Northwestern University
ESRD
A Culturally Targeted Transplant Program
Hispanic/Latino patients with end-stage renal disease are disproportionately less likely to get a kidney transplant, and specifically, a living donor kidney transplant (LDKT), compared to non-Hispanic whites.
- Trial name
- HKTP (NCT03276390)
- Testing
- Hispanic Kidney Transplant Program (HKTP)
- Where
- 4 sites in United States
- Volunteers
- 11,836 people
- Sponsor
- Northwestern University
Deceased Organ Donation, Critical Illness
National Observational Study of Clinical Practices in Deceased Organ Donation
This is a 1-year national prospective cohort study that observes the medical management of consented deceased organ donors at hospitals across Canada with a high volume of deceased donation.
- Conditions
- Deceased Organ Donation, Critical Illness, Transplantation
- Trial name
- CanadaDONATE (NCT03114436)
- Testing
- Observational Data Collection
- Where
- 29 sites in Canada
- Volunteers
- 622 people
- Sponsor
- McMaster University