Clinical trials: Transplant Failure
Premature Ovarian Failure
Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian Failure (POF)
The goal of this study is to determine safety and tolerability and of intra-ovarian injection of adipose derived stromal cell in women with premature ovarian failure and to study the preliminary efficacy ADSCs intra ovarian…
- Trial name
- NCT02603744
- Testing
- Intraovarian injection of Adipose derived Stromal cells (ADSCs)
- Where
- Iran
- Volunteers
- 9 people
- Sponsor
- Royan Institute
Kidney Failure, Kidney Diseases
Expanding Live Donor Kidney Transplantation Through Advocacy Training and Social Media
This pilot study will be a clinical trial to test the feasibility and effectiveness of an educational intervention and a mobile health intervention in adults with end stage renal disease (ESRD) who have not yet identified a…
- Trial name
- ENGAGE (NCT03099434)
- Testing
- Facebook App, Live Donor Champion + Facebook App
- Where
- 2 sites in United States
- Volunteers
- 775 people
- Sponsor
- Johns Hopkins University
Anemia, Aplastic
Safety and Efficacy Study of Ex Vivo Immunotherapy for Treatment of Aplastic Anemia
Our hypothesis is that ex vivo activated immune cells would produce multiple known and unknown potent hematopoietic cytokines, working in concert, these cytokines help stem cell growth and differentiation.
- Trial name
- NCT00399971
- Testing
- Ex Vivo Immunotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Zhongxing Yangfan Biotech Co. Ltd.
Congenital Amegakaryocytic Thrombocytopenia, Diamond-blackfan Anemia
Busulfan, Antithymocyte Globulin, and Fludarabine Followed By a Donor Stem Cell Transplant in Treating Young Patients With Blood Disorders, Bone Marrow Disorders, Chronic Myelogenous Leukemia in First Chronic Phase, or Acute Myeloid Leukemia in First Remission
RATIONALE: Drugs used in chemotherapy, such as busulfan and fludarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Congenital Amegakaryocytic Thrombocytopenia, Diamond-blackfan Anemia, Fanconi Anemia, Leukemia
- Trial name
- NCT00305708
- Testing
- anti-thymocyte globulin, busulfan, fludarabine phosphate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
End-stage Liver Disease
Conditioning With Volatile Anesthetics in Liver Transplantation
The gap between the number of candidates for orthotopic liver transplantation and the availability of suitable liver grafts has led to a rise in deaths on most waiting lists.
- Trial name
- NCT00913276
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- University of Zurich
End Stage Liver Disease
Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes
This Phase 2a clinical trial is a dose escalation study of the safety, tolerability, and efficacy of hepatocyte transplantation into lymph nodes via endoscopic ultrasound among subjects with end-stage liver disease.
- Trial name
- NCT04496479
- Testing
- LYG-LIV0001
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- LyGenesis, Inc.
Transplant;Failure,Kidney
The Learning Curve for Retroperitoneoscopic Donor Nephrectomy
Purpose: The aim of the study is to identify a precise learning curve for pure retroperitoneoscopic donor nephrectomy (RDN). Methods: Data from 172 consecutive kidney donors who underwent pure RDN between January 2010 and July…
- Trial name
- NCT05790746
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Samsun Liv Hospital
Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH)
Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.
Previous data from our group showed reduced BMPR2 isoform A in pulmonary hypertension associated with left heart disease (PH-LHD) of valvular origin.
- Conditions
- Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH), Heart Failure
- Trial name
- BREATHE-PH (NCT07537517)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Liver Failure, Mesenchymal Stem Cells
Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantation
The study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after single transplantation with autologous marrow mesenchymal stem cells (MMSCs).
- Trial name
- NCT00956891
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Sun Yat-sen University
Kidney Failure, Kidney Diseases
Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Kidney Transplant
This is a proof of concept, single center study for the donation of HCV-positive kidney to HCV negative recipient patients, with preemptive, interventional treatment with 12 weeks of commercially available DAA therapy to prevent…
- Conditions
- Kidney Failure, Kidney Diseases, Hepatitis C
- Trial name
- NCT03623568
- Testing
- glecaprevir/pibrentasvir tablets
- Where
- United States
- Sponsor
- Raymond T. Chung, MD
Liver Cirrhosis, Liver Failure
Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant Survival
In recent years, several scoring systems have been developed aimed at predicting early post-LT graft function. However, many of them showed poor efficacy when long-term survivals were tested.
- Conditions
- Liver Cirrhosis, Liver Failure, Liver Diseases, Transplant Failure
- Trial name
- NCT03723317
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 1,782 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Severe Aplastic Anemia, Acquired Amegakaryocytic Thrombocytopenia
MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.
A phase II trial of a reduced intensity conditioned (RIC) allogeneic hematopoietic cell transplant (HCT) with post-transplant cyclophosphamide (PTCy) for idiopathic severe aplastic anemia (SAA), paroxysmal nocturnal…
- Conditions
- Severe Aplastic Anemia, Acquired Amegakaryocytic Thrombocytopenia, Acquired Pure Red Cell Aplasia, Paroxysmal Nocturnal Hemoglobinuria
- Trial name
- NCT06412497
- Testing
- Rituximab, Rabbit ATG, Cyclophosphamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Chronic Renal Failure
Pulsatile Perfusion Preservation in Kidney Transplantation From Expanded Criteria Donors
Our hypothesis is that the Waters Medical® pulsatile perfusion machine (RM 3) is a way to improve delayed graft function (DGF) in marginal grafts, and some perfusion profiles (flow, pressure, resistance index, venous effluent pH)…
- Trial name
- IMPULSION (NCT01170910)
- Testing
- Static incubation, Pulsatile perfusion
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Hospices Civils de Lyon
AML, ALL
UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy
Patients with graft failure or delayed engraftment may benefit from a hematopoietic stem cell boost or an additional hematopoietic stem cell transplantation procedure.
- Conditions
- AML, ALL, Lymphoid Malignancies, Myelodysplastic Syndromes
- Trial name
- NCT06047886
- Testing
- Infusion of CD34 selected hematopoietic stem cells
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Pediatric ALL, Transplant; Failure, Heart
HIIT in Pediatric Heart Transplant Recipients (MedBIKE™)
Heart transplantation is the long-term treatment for children and adults with advanced heart failure. Post-transplant outcomes have improved over time, such that 50% of pediatric heart transplant recipients (HTR) remain alive…
- Trial name
- NCT05451979
- Testing
- MedBIKE HIIT
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Kidney Transplant Failure and Rejection
Treatment of Early Borderline Lesions in Low Immunological Risk Kidney Transplant Patients (TRAINING)
Background: Subclinical inflammation, including borderline lesions (BL), is very common (30-40%) after kidney transplantation (KT), even in low immunological risk patients, and can lead to interstitial fibrosis/tubular atrophy…
- Trial name
- NCT04936282
- Testing
- Grafalon, Normal Treatment
- Where
- 4 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fundación Canaria Instituto de Investigación Sanitaria de Canarias
Lung Transplant Failure and Rejection
Clinical Trials in Organ Transplantation Extension Study
The purpose of the study is to continue to follow subjects who were enrolled in the CTOT-20 CLAD Phenotypes study. Subjects will provide clinical data and complete quality of life questionnaires that will be used to determine the…
- Trial name
- CTOT-ES (NCT04126746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Duke University
End-stage Heart Failure, Cardiomyopathies
VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Pivotal Trial
The purpose of this study is to evaluate the safety and effectiveness of VentrAssistTM LVAD in individuals who are awaiting heart transplants.
- Trial name
- NCT00483197
- Testing
- VentrAssistTM Left Ventricular Assist Device
- Where
- 29 sites in United States
- Volunteers
- 140 people
- Sponsor
- Ventracor
Stenosis, Restenosis
Clinical Study of the BARD® COVERA™ Arteriovenous (AV) Stent Graft
The objective of this study is to assess the safety and effectiveness of the COVERA™ Vascular Covered Stent for the treatment of stenotic lesions in the upper extremity venous outflow of the Arteriovenous (AV) access circuit.
- Trial name
- AVeNEW (NCT02649946)
- Testing
- Covera Vascular Covered Stent following PTA, Percutaneous Transluminal Angioplasty (PTA) with Uncoated PTA Balloon
- Where
- 24 sites in United States, Australia and 6 more
- Volunteers
- 280 people
- Sponsor
- C. R. Bard
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This pilot phase I trial studies the side effects of engineered donor stem cell transplant in treating patients with hematologic malignancies.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Aplastic Anemia
- Trial name
- NCT02960646
- Testing
- Cyclophosphamide, Filgrastim, Fludarabine Phosphate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
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