Clinical trials: Transplant Failure
Obesity, Morbid, Transplant; Failure, Kidney
Effect of Laparoscopic Sleeve Gastrectomy in the Morbidly Obese, Kidney Transplant Candidate
A prospective clinical trial will study the effects of laparoscopic sleeve gastrectomy in the potential renal transplant candidate who is denied acceptance due mainly to the morbid obesity.
- Trial name
- NCT01913392
- Testing
- laparoscopic sleeve gastrectomy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Terminal Renal Failure, BK Virus Infection
BK Viremia After Renal Transplantation
Hypothesis: Early detection, and treatment, of BK virus infection after kidney transplantation will prevent BK virus associated kidney transplant injury.
- Trial name
- NCT00684372
- Testing
- leflunomide
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Kidney Transplant Failure and Rejection
Home Based Monitoring of Kidney Transplants Utilizing Capillary Microsamples
Renal transplant recipients are followed as out patients at the transplant center for about 8 weeks after surgery. Between 1-2 weeks after surgery, 50 standard immunological patients will be randomized (1:1) to either follow…
- Trial name
- HBM-KTx (NCT04369612)
- Testing
- Standard follow-up, Home-based monitoring
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Kidney Failure, Chronic
Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology
Chronic allograft nephropathy is one of dominant causes of long term kidney transplant failure. Its main histological determinant is interstitial fibrosis and tubular atrophy.
- Trial name
- NCT01510795
- Testing
- spironolactone
- Volunteers
- 40 people
- Sponsor
- Clinical Hospital Merkur
Kidney Failure, Kidney Transplant; Complications
Delayed Tolerance Through Mixed Chimerism
This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor).
- Conditions
- Kidney Failure, Kidney Transplant; Complications, Chimera
- Trial name
- NCT05900401
- Testing
- Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes, Diabetes Mellitus, Type 2
AZD1656 in Transplantation With Diabetes tO PromoTe Immune TOleraNce
AZD1656 in Transplantation with Diabetes tO PromoTe Immune TOleraNce: a single site, placebo-controlled, double-blind randomised clinical trial of AZD1656 in renal transplant patients with Type 2 diabetes
- Conditions
- Type 2 Diabetes, Diabetes Mellitus, Type 2, Renal Transplant, Kidney Transplant; Complications
- Trial name
- ADOPTION (NCT05216172)
- Testing
- AZD1656
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Queen Mary University of London
Renal Insufficiency, Chronic, Kidney Failure, Chronic
Exercise Training and Physical Rehabilitation in Patients With Chronic Kidney Disease in Europe - What is the Problem?
This study evaluates possible barriers to physical activity/exercise training for patients with chronic kidney disease in Europe. The study's aim is to investigate structural problems and attitudes at different levels of care.
- Conditions
- Renal Insufficiency, Chronic, Kidney Failure, Chronic, Exercise
- Trial name
- EUSUREX (NCT03923972)
- Where
- 2 sites in Sweden
- Volunteers
- 1,500 people
- Sponsor
- Skane University Hospital
Kidney Transplant Failure and Rejection
A Follow up Study of Patients Treated With Imlifidase Prior to Kidney Transplantation
The rationale for the current protocol is to collect data from extended follow up in subjects that have received a kidney transplant following imlifidase dosing to provide a better understanding regarding the long-term outcome…
- Trial name
- NCT03611621
- Testing
- Imlifidase
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 31 people
- Sponsor
- Hansa Biopharma AB
Liver Transplant Failure
Analysis of Donor-derived Cell Free DNA in Liver Transplant Patients
Determine the levels of Donor-derived (dd)cell-free DNA(cfDNA )in liver transplant recipients with normal liver function tests (LFTs) indicating stable immunosuppression status (IS).
- Trial name
- NCT06225206
- Testing
- donor-derived cell free DNA in liver
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Methodist Health System
Blood Stem Cell Transplant Failure, Leukemia
Mismatched Transplantation Using High-dose Post-transplant Cyclophosphamide
The goal of this clinical research study is to learn about the safety of giving a stem cell transplant from a tissue-mismatched donor, followed by cyclophosphamide, to patients with certain types of blood disorders or blood…
- Conditions
- Blood Stem Cell Transplant Failure, Leukemia, Hematologic Malignancies
- Trial name
- NCT01010217
- Testing
- Cyclophosphamide, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- M.D. Anderson Cancer Center
Renal Transplant Graft Failure
Influence of Pharmaceutical Care on the Intraindividual Variability of Tacrolimus Concentrations
Primary end-point The primary end-point was the influence of pharmaceutical intervention in tacrolimus intra-subject variability during the first 3 months after kidney transplant.
- Trial name
- PharmCare (NCT02402140)
- Testing
- Pharmaceutical Intervention
- Volunteers
- 128 people
- Sponsor
- Hospital do Rim e Hipertensão
Severe Obesity, Renal Failure
Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.
- Trial name
- NCT02128802
- Testing
- Gastric Bypass, Weight Loss Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
End-stage Heart Failure
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
In the DAPA-HF trial, the use of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduced significantly the risk of worsening heart failure or death from cardiovascular causes compared to placebo among…
- Trial name
- ARCADIA-HF (NCT04782245)
- Testing
- Dapagliflozin 10mg
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Liver Cirrhoses, Liver Failure
Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit
Critically-ill patients with liver disease are at high risk of developing sarcopenia and intensive care unit (ICU)-acquired weakness, which are associated with mortality and other poor outcomes.
- Conditions
- Liver Cirrhoses, Liver Failure, ICU Acquired Weakness
- Trial name
- NCT04160039
- Testing
- Cycle ergometry
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Medical College of Wisconsin
End-Stage Renal Disease, End Stage Renal Disease on Dialysis
CRISPR-Edited HLA Donor Kidney Transplant to Reduce Rejection Risk
This clinical trial investigates the transplantation of donor kidneys that have been genetically modified ex vivo using CRISPR-Cas9 genome editing to reduce immunogenicity and transplant rejection.
- Conditions
- End-Stage Renal Disease, End Stage Renal Disease on Dialysis, End Stage Renal Disease With Renal Transplant, Kidney Transplant Rejection
- Trial name
- NCT07053462
- Testing
- Ex Vivo CRISPR-Cas9 Gene Editing of Donor Kidney, Kidney Transplantation with Standard Care
- Where
- China
- Volunteers
- 90 people
- Sponsor
- AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC
Leukemia
Safety and Efficacy of LPE in Clearing DSA in Patients Who Received Allo-HSCT
The aim of this study is to prospectively explore the effectiveness and safety of LPE in clearing DSA, and to investigate the clinical efficacy of a combination therapy with LPE in patients undergoing genetic hematopoietic stem…
- Trial name
- NCT06177561
- Testing
- Lymphoplasma exchange
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
End Stage Renal Disease
Myfortic vs. Cellcept in Kidney Transplant Recipients
The comparison the incidence of G.I. toxicity between Myfortic® vs. Cellcept® in 150 sequential patients, in which 75 will be randomized to Cellcept® and 75 to Myfortic® in first and second living or deceased donor renal…
- Trial name
- NCT00533624
- Testing
- Mycophenolate Sodium Delayed Release Tablets, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Kidney Failure, Transplant Recipient (Kidney)
Tolerance Through Mixed Chimerism (Sip-Tego)
This is an open-label, single-institution study to assess the safety and the efficacy of the Sip-Tego regimen for the induction of donor-specific immunologic unresponsiveness to a renal allograft.
- Conditions
- Kidney Failure, Transplant Recipient (Kidney), Transplant Tolerance, Immunosuppresion
- Trial name
- NCT06972069
- Testing
- Combined Kidney/Bone Marrow Transplant, Donation of Kidney / Bone Marrow, Conditioning Regimen (Rituxan, Siplizumab (or ATGAM), Cyclophosphamide, Tegoprubart)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Tatsuo Kawai, MD, PhD
Heart Failure
XVIVO Heart Transplant Study in Clinical Practice
HOPE for All is a clinical investigation to support the use of hypothermic oxygenated perfusion (HOPE) using a revised XVIVO Heart Assist Transport System in a real- world setting.
- Trial name
- HOPE for All (NCT07556588)
- Testing
- XVIVO Heart Assist Transport System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- XVIVO Perfusion
Cardiac Resynchronization Therapy, Heart Failure
Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).
- Trial name
- CONSYST-CRT II (NCT06105580)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Hospital Clinic of Barcelona
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