Clinical trials: Transplant Recipients
Kidney Transplantation
Alefacept in Kidney Transplant Recipients
Alefacept, also known as Amevive®, is a medication approved by the Food and Drug Administration (FDA) in the United States and other countries for the treatment of psoriasis, which is a chronic inflammatory immunological skin…
- Trial name
- NCT01433770
- Testing
- Amevive
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Type 1 Diabetes Mellitus, Hypoglycemia
MGA031, Sirolimus and Tacrolimus in Islet Transplantation
This clinical trial is designed to extend the observations made in our pilot clinical trial (IND 8971, Study #1) on the safety and efficacy of immunotherapy with the anti-CD3 monoclonal antibody hOKT3γ1 (Ala-Ala), (currently…
- Trial name
- NCT00265473
- Testing
- Allogeneic Islets of Langerhans
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Renal Impairment, Liver Transplantation
CNI-free "Bottom"-up Immunosuppression in Patients Undergoing Liver Transplantation
The primary objective of the trial is to evaluate efficacy and safety of delayed introduction (up to 30 days post-transplantation in patients without signs of acute rejection that had received an aIL-2 induction and MMF) of…
- Conditions
- Renal Impairment, Liver Transplantation, Everolimus
- Trial name
- BUILT_01 (NCT01023542)
- Testing
- delayed, low-dose CNI, BU-CNI, BU-Everolimus
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Regensburg
Kidney Transplantation
Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Kidney Transplant Recipients
This study will investigate the safety, tolerability and efficacy of EC-MPS with tacrolimus at both reference and reduced levels.
- Trial name
- NCT00229138
- Testing
- EC-MPS, Tacrolimus
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Allograft Nephropathy, Chronic Kidney Disease
Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients
Hyperparathyroidism (HPT) is common in people with a kidney transplant. Patients with HPT often have high parathyroid hormone (PTH) levels and may have large parathyroid glands in the neck.
- Conditions
- Chronic Allograft Nephropathy, Chronic Kidney Disease, Chronic Renal Failure, Disordered Mineral Metabolism
- Trial name
- NCT00975000
- Testing
- Cinacalcet
- Where
- 51 sites in United States, Australia and 9 more
- Volunteers
- 114 people
- Sponsor
- Amgen
Recurrent Diffuse Large B-Cell Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells
This phase II trial tests how well fecal microbiome transplantation works to remodel intestinal microbiota for patients with lymphoma that has come back after a period of improvement (relapsed) or that does not respond to…
- Conditions
- Recurrent Diffuse Large B-Cell Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements, Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
- Trial name
- NCT07042438
- Testing
- Axicabtagene Ciloleucel, Biospecimen Collection, Chemotherapy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- City of Hope Medical Center
Prophylaxis Against Liver Transplant Rejection
Bioavailability and Practicability of Envarsus Versus Advagraf in Liver Transplant Recipients
Trial participants are randomised within 14 days after liver transplantation surgery in a 1:1 ratio to two alternative treatment arms containing either Envarsus® (test arm) or Advagraf® (comparator arm) as first-line calcineurin…
- Trial name
- NCT04720326
- Testing
- Tacrolimus Pill, Tacrolimus capsule
- Where
- 15 sites in Germany
- Volunteers
- 268 people
- Sponsor
- Edward Geissler
Pediatric Heart Transplantation, Pediatric Heart Transplant Recipients
Alloantibodies in Pediatric Heart Transplantation
The purpose of this study is to determine the clinical outcomes of sensitized pediatric heart transplant recipients with a positive donor-specific cytotoxicity crossmatch and to compare this group with outcomes in nonsensitized…
- Trial name
- NCT01005316
- Testing
- Induction Therapy, Tacrolimus, Mycophenolate Mofetil
- Where
- 8 sites in United States, Canada
- Volunteers
- 290 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Organ Transplantation, Renal Transplantation
Everolimus in a Cyclosporine Microemulsion-free Regimen Compared to a Low-dose Cyclosporine Microemulsion Regimen, in de Novo Kidney Transplant Patients
The purpose of this study is to evaluate the safety and efficacy of everolimus in combination with basiliximab, and steroids with and without cyclosporine microemulsion in de novo kidney transplant recipients.
- Trial name
- CERTES02 (NCT00154284)
- Testing
- Everolimus (Certican), Cyclosporine (Neoral), Steroid
- Volunteers
- 114 people
- Sponsor
- Novartis
Exposure to Hepatitis B Virus
Risk of Hepatitis B Reactivation After Bone Marrow Transplantation With Prior Hepatitis B Virus (HBV) Exposure
The purpose of this study is to determine whether preemptive nucleoside analogue therapy or regular virologic monitoring is the preferred method in management patients with prior exposure to hepatitis B vius (HBV) and undergoing…
- Trial name
- NCT01481649
- Where
- Hong Kong
- Volunteers
- 69 people
- Sponsor
- The University of Hong Kong
Lung Diseases
Prophylaxis Guided by Cytomegalovirus-specific T Cell Immunity to Prevent Cytomegalovirus Disease in Lung Transplant Recipients
The purpose of this study is to evaluate the clinical outcomes of Cytomegalovirus (CMV) virus in the participants' body. Therefore, the study team will follow the participants' immunological response based on the Cytomegalovirus…
- Trial name
- NCT06494033
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Chronic Rejection, Kidney Insufficiency
Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients
The purpose of this study is to determine if administration of rituximab blocks the development of donor specific antibodies (DSA) in transplant recipients who have developed renal dysfunction and DSA after renal transplant.
- Trial name
- NCT00261547
- Testing
- Rituximab
- Sponsor
- Massachusetts General Hospital
Hepatitis B, Liver Transplantation
Adefovir Plus Vaccination in Transplant Patients Without Hepatitis B That Receive a Core Antibody Positive Liver
The primary purpose of this study is to evaluate the efficacy of adefovir (ADV) in preventing de novo Hepatitis B in patients who receive Hepatitis B core antibody (HBcAb) positive grafts but who are not Hepatitis B Surface…
- Trial name
- NCT01146808
- Testing
- Adefovir dipivoxil and hepatitis B vaccination
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Lung Transplant Recipient
Safety and Efficacy Study of Inhaled AmBisome for Prevention of Aspergillus Colonization in Lung Transplant Recipients
Lung transplant recipients have the highest rate of Invasive Aspergillus (IA)infection among solid organ transplant recipients. The most important risk factor for the development of IA (which is associated with disease and death)…
- Trial name
- NCT01254708
- Testing
- Ambisome ®, Regular standard of care medication
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Renal Transplant Recipients
Effects of Whole-body Vibration Training on the Heart Rate Variability Cardiac in Kidney Transplantation
Introduction: Renal transplantation represents the therapeutic mode with more durable treatment, greater cost-effectiveness, survival benefits and quality of life of the patients, however, with high cardiovascular mortality.
- Trial name
- NCT03110406
- Testing
- whole-body vibration training
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Renal Transplant Rejection, Fibrosis
Mesenchymal Stromal Cell Therapy in Renal Recipients
This study will test the hypothesis that MSCs in combination with Everolimus facilitate Tacrolimus withdrawal, reduce fibrosis and decrease the incidence of opportunistic infections compared to standard tacrolimus dose.
- Trial name
- MSCs (NCT02057965)
- Testing
- Mesenchymal Stromal Cells
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Leiden University Medical Center
Kidney Transplantation
A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based
The primary purpose is to assess the benefits and risks of changing from Cyclosporine or Tacrolimus to Belatacept between 6-60 months after kidney transplant.
- Trial name
- NCT01820572
- Testing
- Belatacept, Tacrolimus, Cyclosporine
- Where
- 117 sites in United States, Argentina and 8 more
- Volunteers
- 446 people
- Sponsor
- Bristol-Myers Squibb
Renal Transplant
Kidney Transplant Low-AGE Diet Study
The purpose of the present study is to test the feasibility of conducting a larger randomised controlled trial (RCT) which will investigate whether a diet low in toxins called advanced glycation end-products (AGEs) decreases skin…
- Trial name
- Transplant LAD (NCT05104242)
- Testing
- Diet low in Advanced Glycation End-Products (AGE)
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Heart Transplant Recipients
Autonomic Cardiovascular Control After Heart Transplantation
The purpose of this prospective study is to investigate denervation (ie. surgical cutting of autonomic nerves) and re-innervation (ie. growth of autonomic nerves) in heart transplant recipients. More specifically, we focus on: 1.
- Trial name
- AccHeart (NCT01759966)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Kidney Transplant Rejection
Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants
The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-103 for induction of functional immune tolerance in past recipients of human leukocyte antigen (HLA)-matched, living…
- Trial name
- NCT03606746
- Testing
- MDR-103
- Sponsor
- Medeor Therapeutics, Inc.