Clinical trials: Transplantation, Liver
End Stage Liver Failure
N-acetylcysteine in Liver Transplantation
N-acetylcysteine (NAC) is used to treat Tylenol toxicity. NAC is a rich source of the sulfhydryl group (SH) which is important for replenishing the body's glutathione stores.
- Trial name
- NAC (NCT00736541)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ibtesam Hilmi
Cirrhosis, Liver
Graft Inflow Modulation for Portal Hyper-perfusion in Live Donor Liver Transplantation
In this study, the investigators aim to prove that performing graft inflow modulation (GIM) in liver with portal hyper-perfusion is beneficial for early graft function postoperatively.
- Trial name
- NCT04252794
- Testing
- Splenic artery ligation, No intervention
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Intrahepatic Cholangiocarcinoma
Liver Transplantation for Early Intrahepatic Cholangiocarcinoma
Diagnosis of intrahepatic cholangiocarcinoma (iCCA) is increasingly common in patients with liver cirrhosis, but these patients are denied liver transplantation (LT) by most centres due to historically poor results.
- Trial name
- LT for iCCA (NCT02878473)
- Testing
- Deceased donor Liver Transplantation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Liver Diseases
Drug Use Investigation for IMURAN (Azathioprine) Tablet (Hepatic Transplantation)
This post-marketing surveillance (PMS) study is designed to investigate the efficacy and safety of azathioprine tablets in Japanese subjects whom liver transplantation is performed.
- Trial name
- NCT01390766
- Testing
- Azathioprine
- Volunteers
- 41 people
- Sponsor
- GlaxoSmithKline
COVID-19 Pandemic, Transplant-Related Disorder
EVALUATION OF DIFFERENT PROPHYLACTIC INTERVENTIONS TOWARD COVID-19 IN SOLID ORGAN TRANSPLANT PATIENTS
The goal of this observational study is to evaluate the immune response after COVID-19 vaccination in Liver(LT) and Kidney(KT) transplant recipient.
- Trial name
- NCT05629923
- Testing
- tixagevimab-cilgavimab(AZD7442, AstraZeneca)
- Where
- Italy
- Volunteers
- 306 people
- Sponsor
- University of Rome Tor Vergata
Incisional Hernia of Anterior Abdominal Wall
Study on the Efficacy of Prophylactic on Lay Mesh in Preventing Post-operative Hernia in Liver Transplant Patients
Study Design: Single-blinded, randomized, prospective clinical trial. Study Population: End-stage liver disease patients' candidates for liver transplantation.
- Trial name
- NCT04512469
- Testing
- Low molecular weight mesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication
FSTL1 and PPCs on Pediatric Within LDLT:a Prospective Cohort Analysis
The goal of this observational study is to identify the association between FSTL1 elevation and acute lung injury (ALI) after pediatric liver transplantation.The main questions it aims to answer what the risk factors are for ALI…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication, Liver Transplant; Complications
- Trial name
- NCT05807802
- Volunteers
- 400 people
- Sponsor
- Tianjin First Central Hospital
Cirrhosis, Liver
The Establishment of Multiple Point Prediction Model About Tacrolimus Metabolic Differences Based on Genetic Network After Liver Transplantation and the Application of Multicenter
Combined with the clinical data of FK506 and the database of GO and Kyoto Encyclopedia of Genes and Genomes（KEGG）, the investigators aim to carry out the bioinformatic analysis and build a muti-locus genetic model, then…
- Trial name
- NCT02752529
- Testing
- Tacrolimus（FK506）
- Where
- China
- Volunteers
- 415 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Hepatocellular Carcinoma
SBRT as Bridging Therapy for Hepatocellular Carcinoma Patients on Transplant Waitlist
This is a single center, prospective study to assess the efficacy and safety of using stereotactic body radiation therapy (SBRT) as bridging treatment for hepatocellular carcinoma (HCC) patients on transplant waitlist.
- Trial name
- NCT03950102
- Testing
- SBRT
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Liver Cancer, Dropout, Patient
A Worldwide Score for Hepatocellular Cancer and Liver Transplantation
The present study has been developed with multiple aims: 1) to refine available models for liver transplantation which would be able to cover the fate of HCC candidates from an ITT point of view; 2) to develop such an approach on…
- Conditions
- Liver Cancer, Dropout, Patient, Recurrence
- Trial name
- TRAIN-SCORE (NCT03595345)
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 3,100 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Heart Failure, Respiratory Failure
Donor Simvastatin Treatment in Organ Transplantation
The aim of the study is to investigate the effects of donor simvastatin treatment on ischemia-reperfusion injury after heart transplantation.
- Conditions
- Heart Failure, Respiratory Failure, Liver Failure, Kidney Failure
- Trial name
- SIMVA (NCT01160978)
- Testing
- Simvastatin 80mg, Control Rx
- Where
- Finland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Medication Adherence, Liver Transplant
A Pilot Study of mDOT for Immunosuppressant Adherence in Adult Liver Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppressant medication adherence among adult liver transplant recipients.
- Trial name
- NCT03515330
- Testing
- mHealth Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
Liver Transplantation, Kidney Transplantation
A Study of Modigraf® (Tacrolimus Granules) to Evaluate the Pharmacokinetics and Long-term Safety and Efficacy in De Novo Pediatric Allograft Liver and Kidney Transplantation Recipients
The purpose of this study is to determine the pharmacokinetics of tacrolimus following oral administration of Modigraf, after the first oral dose and at steady state in pediatric participants undergoing de novo allograft liver or…
- Trial name
- NCT05152628
- Testing
- Tacrolimus granules
- Where
- 4 sites in China
- Volunteers
- 55 people
- Sponsor
- Astellas Pharma China, Inc.
Fatty Liver, Steatosis of Liver
Prediction of Donor Liver Adipose Content by Magnetic Resonance Imaging
A pilot prospective cohort study assessing the clinical utility of MRI evaluation of graft steatosis prior to transplantation will be conducted.
- Trial name
- NCT02873507
- Testing
- MRI of donor liver prior to transplant
- Sponsor
- Vanderbilt University Medical Center
Growth Failure, Chronic Liver Disease
Increlex Treatment of Children With Chronic Liver Disease and Short Stature
A major consequence of chronic liver disease in childhood is growth failure. This is because a chemical essential for growth called growth factor is created in the liver.
- Trial name
- NCT01314508
- Testing
- Increlex
- Sponsor
- University of California, Los Angeles
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells.
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer
- Trial name
- NCT00002515
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Liver Failure
Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Safety in Liver Transplant Patients
The goal of this observational study is oo compare the pharmacokinetic parameters of different tacrolimus containing medications in liver transplant patients.
- Trial name
- LTA (NCT05744635)
- Testing
- Tacrolimus
- Where
- 2 sites in Hungary, Slovenia
- Volunteers
- 110 people
- Sponsor
- Chiesi Hungary Ltd.
Primary Liver Transplant
Mycophenolate Mofetil Maintenance Therapy for Liver Transplantation
The rationale for this study is to determine if Campath-1H can be used in liver transplant recipients to induce a state of immunological unresponsiveness that would not only eliminate the need for calcineurin inhibitors…
- Trial name
- NCT00849238
- Testing
- mycophenolate mofetil
- Sponsor
- University of Wisconsin, Madison
Immunosuppression, Immune Tolerance
Liver Immune Tolerance Marker Utilization Study
The purpose of this study is to validate and test a tolerance gene expression profile for the identification of operationally tolerant liver transplant recipients, allowing for the successful withdrawal of immunosuppression…
- Trial name
- LITMUS (NCT02541916)
- Testing
- Controlled weaning of immunosuppression
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Toronto
Hepatitis C Virus Infection
Sofosbuvir/Velpatasvir Fixed-Dose Combination in HCV-Infected Adults Who Are Undergoing Liver Transplantation
The primary objectives of this study are to evaluate the antiviral efficacy, safety, and tolerability of sofosbuvir/velpatasvir (SOF/VEL) fixed-dose combination (FDC) in hepatitis C virus (HCV)-infected adults who are undergoing…
- Trial name
- NCT02728206
- Testing
- SOF/VEL
- Where
- New Zealand
- Volunteers
- 9 people
- Sponsor
- Gilead Sciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.