Clinical trials: Transplantation, Liver
Pediatric Recipients of a Liver Transplant
Medication Adherence in Children Who Had a Liver Transplant
The purpose of this study is to evaluate the use of a novel method to measure adherence to immunosuppressant medications in predicting rejection episodes in children who had a liver transplant.
- Trial name
- MALT (NCT01154075)
- Where
- 5 sites in United States
- Volunteers
- 401 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sarcopenia in Liver Cirrhosis
Assessment of Sarcopenia in Patients With Liver Cirrhosis and Its Prognostic Value in Liver Transplant Candidates
Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, shown to be prevalent in adults with cancer and common chronic comorbidities such as liver cirrhosis.
- Trial name
- NCT03629444
- Testing
- ct scan
- Volunteers
- 300 people
- Sponsor
- marwa abdElRazek Ahmed sala.a makhlof
Liver Diseases, Liver Transplant; Complications
Design and Implementation of the Pediatric Liver Transplantation Biobank
The purpose of the pediatric liver transplant biobank is to systematically collect clinical specimens from pediatric end-stage liver disease.
- Conditions
- Liver Diseases, Liver Transplant; Complications, Pediatric ALL
- Trial name
- NCT04477967
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Liver Transplantation, Chronic Renal Insufficiency
Safety Study of Calcineurin-Inhibitor-Free Immunosuppression After Liver Transplantation
A prospective, non-randomized two stage monocentric phase II clinical trial to evaluate a de-novo calcineurin-inhibitor (CNI)-free immunosuppressive regimen based on induction therapy with anti-CD25 monoclonal anti-body…
- Trial name
- CILT (NCT00890253)
- Testing
- Basiliximab (Simulect), Myfortic, everolimus
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- Armin Goralczyk
Chronic Hepatitis C-virus Infection, Renal Transplantation
Hepatitis C in Renal Transplant Recipients
The aim of the present trial is to evaluate whether the conversion of immunosuppression from tacrolimus to cyclosporine A induces changes in (i) hepatitis C-virus load, (ii) parameters of hepatic function and (iii) parameters of…
- Trial name
- NCT02108301
- Testing
- tacrolimus-cyclosporine A
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Prof. Dr. Alice Schmidt
Liver Transplantation, Hepatitis
Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation
The purpose of the study is to test the safety and effectiveness of IDN-6556 in preventing liver damage that normally occurs when livers are transported before being transplanted and in the immediate post-transplant period.
- Conditions
- Liver Transplantation, Hepatitis, Cholestasis, Carcinoma, Hepatocellular
- Trial name
- NCT00080236
- Testing
- IDN-6556
- Where
- 13 sites in United States, Germany
- Volunteers
- 99 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Liver Diseases
Uncertainty Management Intervention
The goal of this study is to improve symptoms and quality of life for end-stage liver disease patients awaiting a liver transplant and their caregivers by providing them with the resources and tools to self-manage their complex…
- Trial name
- NCT00938795
- Testing
- Uncertainty Management Intervention, Comparison Conditions for Liver Transplant
- Where
- 4 sites in United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Duke University
Living Donor Liver Transplantation
Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT
The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.
- Trial name
- NCT04184401
- Testing
- Ascites replacement with albumin and hartmann's solution, Ascites replacement with hartmann's solution
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Liver Transplant Disorder
Nomogram for Predicting Biliary Complication
The goal of this observational study is to develop a nomogram model to predict biliary complications within 90 days in adult patients after liver transplantation.
- Trial name
- NPBC (NCT06658665)
- Volunteers
- 900 people
- Sponsor
- Sun Yat-sen University
Liver Cirrhosis
Human Fetal Liver Cell Transplantation in Chronic Liver Failure
The herein study consists in the transplantation of liver progenitor cells isolated from human fetal liver tissue with the aim of improving conventional liver therapy and broadening therapeutical options other than liver…
- Trial name
- hFLCTx (NCT01013194)
- Testing
- Human Fetal Liver Cell Transplantation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Uveal Malignant Melanoma
Liver Transplantation and Uveal Malignant Melanoma
Patients with uveal malignant melanoma with liver metastases have median survival of less than 12 months. There is no established treatment showing increased overall survival.
- Trial name
- NCT01311466
- Testing
- Liver transplantation
- Where
- Norway
- Volunteers
- 2 people
- Sponsor
- Oslo University Hospital
Liver Transplant; Complications
POCS in Liver Transplantation Patients
A prospective, multi-center, non-randomized, observational, consecutive case series, which will compare Endoscopic Retrograde Cholangiopancreatoscopy (ERCP) and cholangioscopy with Spy Glass Digital System (DS) procedure at 5-10…
- Trial name
- NCT03205072
- Testing
- Spy Glass DS
- Where
- 5 sites in United States, Brazil and 2 more
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation
Liver Diseases
Exercise Intervention in Liver Transplant Candidates
The aim of the study is to investigate the effect of personalised exercise interventions in liver transplant candidates, aiming to prevent or limit sarcopenia and frailty, as well as improving their cardiorespiratory health.
- Trial name
- NCT04924595
- Testing
- Personalised exercise
- Where
- 2 sites in Greece
- Volunteers
- 30 people
- Sponsor
- Aristotle University Of Thessaloniki
End-Stage Liver Disease, Liver Transplantation
Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates
This study will evaluate frailty, nutrition, sarcopenia, and psychological health in people waiting for a liver transplant. The purpose is to understand how these factors affect outcomes before and after transplantation.
- Conditions
- End-Stage Liver Disease, Liver Transplantation, Cirrhosis
- Trial name
- NCT07414095
- Testing
- Comprehensive Observational Assessment in Liver Transplant Candidates
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Bakircay University
Hepatitis C Infection, Viruses
Civacir® Polyclonal Immune Globulin (IgG) to Prevent Hepatitis C Virus (HCV) Recurrence in Liver Transplant Patients.
The purpose of this study is to test the safety and efficacy of Civacir® to prevent the recurrence of Hepatitis C Virus (HCV) after liver transplant.
- Conditions
- Hepatitis C Infection, Viruses, Hepatocellular Carcinoma, Hepatitis, Viral, Human
- Trial name
- NCT01804829
- Testing
- Civacir® 10%
- Where
- 23 sites in United States
- Volunteers
- 80 people
- Sponsor
- Biotest Pharmaceuticals Corporation
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Liver Transplantation, Physical Fitness
A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise Intensity
Research demonstrated that transplant recipients benefit from physical activity, but there is a gap in knowledge regarding the required intensity.
- Trial name
- PHOENIX-L (NCT06302205)
- Testing
- Physical activity
- Where
- Belgium
- Volunteers
- 147 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Failure
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function
Tacrolimus is the standard immunosuppressive drug used to prevent organ rejection post liver transplant. One side effect of Tacrolimus is nephrotoxicity. Everolimus does not have the nephrotoxicity side effects of Tacrolimus.
- Trial name
- NCT04258423
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Liver Transplant Disorder, Coagulopathy
Thromboelastometry in Liver Transplantation
Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation.
- Trial name
- NCT03011827
- Testing
- Fibrinogen and/or platelets administration
- Where
- 2 sites in Spain
- Volunteers
- 65 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplantation
Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients
To test the effect of low-dose dexmedetomidine for lowering the incidence of postoperative delirium in liver transplant patients in the ICU.
- Trial name
- NCT02245256
- Testing
- Precedex
- Where
- South Korea
- Volunteers
- 217 people
- Sponsor
- Seoul National University Hospital
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