Clinical trials: Transplantation, Liver
Liver Transplantation
Safety Study of Multipotent Progenitor Cells for Immunomodulation Therapy After Liver Transplantation
MultiStem ® is a new biological product, manufactured from human stem cells obtained from adult bone marrow. Factors expressed by MultiStem cells are believed to regulate immune system function and augment tissue repair.
- Trial name
- NCT01841632
- Testing
- MultiStem
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Prof. Dr. Marc-H. Dahlke, Ph. D.
Liver Transplantation
The Predictors for Continuous Renal Replacement Therapy in Liver Transplant Patient
Background. Acute renal failure after liver transplantation (LT) requiring continuous renal replacement therapy (CRRT) adversely affects patient survival.
- Trial name
- NCT01457534
- Where
- South Korea
- Volunteers
- 148 people
- Sponsor
- Yonsei University
Liver Transplant; Complications, Hepatitis C
Hepatitis C Positive Organ to Recipient Hepatitis C Negative Longitudinal Transplant Study
Compare wait list mortality and time to liver, heart or kidney transplant for registrants listed to consider allografts from Hepatitis C Virus (HCV) Nucleic Amplification Testing (NAT)+ donors versus those who are not .
- Trial name
- HERCULES (NCT04057001)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Yale University
Liver Transplantation
Sirolimus-based Immunosuppression Treatment Regimen for Liver Transplantation
This is a multicenter, open-label, randomized, controlled clinical trial, in order to compare sirolimus-based (tacrolimus-free) versus tacrolimus-based (sirolimus-free) immunosuppression regimen for Hepatocellular Carcinoma (HCC)…
- Trial name
- NCT03500848
- Testing
- Tacrolimus, Tacrolimus (Tacrolimus elimination), Sirolimus
- Where
- 3 sites in China
- Volunteers
- 130 people
- Sponsor
- Southern Medical University, China
Carcinoma, Hepatocellular
Safety and Efficacy of Everolimus Treatment in Liver Transplantation for Liver Cancer
This study is a prospective Phase IV study to determine if the use of Everolimus results in lower liver tumor recurrence and improved patient and graft survival after liver transplant for hepatocellular carcinoma (HCC).
- Trial name
- NCT02081755
- Testing
- Everolimus, Tacrolimus, Myfortic
- Where
- 9 sites in United States
- Volunteers
- 336 people
- Sponsor
- Baylor Research Institute
Kidney Transplant Recipients, Liver Transplant Recipients
Pharmacokinetic Studies of Tacrolimus in Transplant Patients
The study is designed to compare the steady-state pharmacokinetics of Prograf (Brand) and the two most disparate generic formulations (Generic Hi and Generic Lo) in a fully replicated, 3-way cross-over study in stable kidney…
- Trial name
- PK (NCT01889758)
- Testing
- Prograf, Tacrolimus
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Cincinnati
Liver Transplantation, Renal Insufficiency, Chronic
Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and…
- Trial name
- NCT05326399
- Testing
- renal biospy
- Where
- 2 sites in China
- Volunteers
- 369 people
- Sponsor
- RenJi Hospital
Liver Transplantation
A Study of Patient Adherence and Convenience to Immunosuppressive Agents in Newly Liver Transplant
A study of patient adherence and convenience to immunosuppressive agents in newly liver transplant recipients - a prospective, multi-center, open-labeled, randomized clinical trial for comparison between once-daily early…
- Trial name
- NCT03216447
- Testing
- Advagraf, Prograf
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Liver Transplant; Complications
Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation
The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion.
- Trial name
- NCT06307158
- Volunteers
- 998 people
- Sponsor
- Zhejiang University
Liver Transplant; Complications
Study to Compare the Incidence of Biliary Complications After Liver Transplantation
A randomized prospective study will be conducted of patients at Vanderbilt University Medical Center who undergo liver transplantation from March 2014 until approximately 120 patients are randomized.
- Trial name
- NCT03165916
- Testing
- Bard 5 Fr diameter feeding tube
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Vanderbilt University Medical Center
Immunosuppression, Hepatocellular Carcinoma
Liver Transplantation Results in Hepatocellular Carcinoma Patients With Immunosuppression Without Steroids
The purpose of this study was to evaluate the safety and efficacy of a steroid-free immunosuppression protocol in Hepatocellular Carcinoma (HCC) patients.
- Conditions
- Immunosuppression, Hepatocellular Carcinoma, Liver Transplantation, Post-operative Complications
- Trial name
- NCT01137084
- Testing
- solu medrol, a steroid-free immunosuppression protocol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Immunosuppression After Liver Transplantation
Conversion Prograf® to Advagraf® at D7 Versus D90 After Liver Transplantation
The best period for the conversion from Prograf (tacrolimus administered twice daily) to Advagraf (once-daily prolonged-release tacrolimus) remains unknown.
- Trial name
- Conversion (NCT02105155)
- Testing
- Conversion at day 7 ± 3 Prograf® to Advagraf®, Conversion at day 90±5 Prograf® to Advagraf®
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
End Stage Liver Disease, Liver Diseases
Normothermic Liver Preservation Trial
This trial is to assess the safety and efficacy of normothermic machine perfusion (NMP) as an organ preservation method prior to transplantation using the OrganOx metra™ device.
- Trial name
- NCT03089840
- Testing
- OrganOx metra
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
Renal Failure Chronic, Hepatitis C
Multi-center Study to Transplant Hepatitis-C Infected Kidneys
Open label multi center study for the donation of HCV positive kidneys to HCV negative recipients with interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- MYTHIC (NCT03781726)
- Testing
- glecaprevir/pibrentasvir treatment
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Raymond Chung
Hepatitis C, Cirrhosis
Transplant-Related Accelerated Progression of Hepatitis C
This study will explore why severe scarring of the liver (cirrhosis) develops so rapidly in hepatitis C-infected patients who have had a liver transplant and possibly in kidney transplant patients as well.
- Trial name
- NCT00368225
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Children With Liver Transplant
VIRTUAL REALITY GLASSES, CHILDREN WITH LIVER TRANSPLANTATION
The aim of the study is to determine the effect of SGG application on pain, anxiety/anxiety, fear and physiological variables during dressing in children aged 4-10 years with liver transplantation.
- Trial name
- NCT05420025
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Firat University
Living Donor Liver Transplantation
Impact of Splenic Artery Ligation in LDLT for Patients With Portal Hypertension
In this study, the investigators aim to prove that performing splenic artery ligation in living donor liver transplantation for patients with portal hypertension is beneficial for early graft function postoperatively.
- Trial name
- NCT04988100
- Testing
- splenic artery ligation, No intervention
- Volunteers
- 30 people
- Sponsor
- Assiut University
Hepatitis B, Chronic
Evaluation of Serum Levels and Pharmacokinetics of a New Hepatitis B Immune Globulin Following Liver Transplantation
The purpose of this study is to determine whether protective anti-HB serum levels are maintained after 6 months of uninterrupted treatment with IGIV-HB Grifols, a new specific hepatitis B immune globulin, in patients having…
- Trial name
- NCT00838071
- Testing
- Specific intravenous anti-hepatitis B immunoglobulin
- Where
- 4 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Instituto Grifols, S.A.
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