Clinical trials: Transplantation, Liver
End Stage Liver Disease, End Stage Renal Disease
Transplant and Addiction Project (TAP) - 1
The purpose of this study is to test a novel distance-based (telephone) intervention to help transplant candidates with current or recent substance abuse to stay "clean and sober" both prior and following transplant surgery.
- Conditions
- End Stage Liver Disease, End Stage Renal Disease, Substance-Related Disorders
- Trial name
- NCT00249652
- Testing
- TAP, TAU
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Obesity, Liver Cirrhosis
Endoscopic Intragastric Balloon Placement for Weight Loss in Liver Transplant Waitlist Candidates
The purpose of this study is to determine whether the Orbera Intragastric Balloon is a safe and effective means for weight loss and improved metabolic disease in patients with cirrhosis requiring liver transplantation.
- Trial name
- NCT02556138
- Testing
- ORBERA Intragastric Balloon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Liver Cirrhosis
Autologous Bone Marrow Mesenchymal Stem Cells Transplantation Via Hepatic Artery in Patients With Liver Cirrhosis
The purpose of this study is to investigate the efficacy of autologous bone marrow mesenchymal stem cells (MSCs) transplantation via hepatic artery in the treatment of liver cirrhosis.
- Trial name
- NCT00976287
- Testing
- Hepatic artery infusion, Conserved Therapy
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma
Neoadjuvant Combination Therapy of Lenvatinib and TACE for Transplant-Eligible Large Hepatocellular Carcinoma Patients
This study will examine the effects of a six-month regimen of neoadjuvant lenvatinib in combination with transcatheter arterial chemoembolization (TACE) prior to liver transplantation in patients with hepatocellular carcinoma…
- Trial name
- NCT05171335
- Testing
- Lenvatinib, Transcatheter Arterial Chemoembolization
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Methodist Hospital Research Institute
Liver Transplant
Fluid Management Strategies on Blood Loss in Liver Transplantation
During liver transplantation, due to the complexity of the operation and abnormal coagulation function, there may be a large amount of bleeding and corresponding blood transfusion.
- Trial name
- NCT06215404
- Testing
- Liberal group, restrictive group
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Sarcopenic Obesity
Sarcopenic Obesity in Liver Transplanted Patients
The prevalence of obesity in cirrhotic patients who are candidates for liver transplantation (LT) is increasing, a phenomenon consistent with the increased prevalence of obesity in the general population.
- Trial name
- OSaLT (NCT05029713)
- Testing
- Evaluation of appendicular skeletal muscle mass (ASMM) by bioelectrical impedance analysis (BIA)
- Where
- 2 sites in Italy
- Volunteers
- 400 people
- Sponsor
- University of Bari
Anxiety Postoperative
Anxiety Levels in Living Liver Donors
Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates.
- Trial name
- NCT07576920
- Testing
- Anxiety scores
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplant Disorder
Perioperative Factors and Living Donor Liver Transplantation
Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis.
- Trial name
- NCT06312098
- Testing
- remote ischemic preconditioning (RIPC)
- Volunteers
- 533 people
- Sponsor
- Min Suk Chae
Liver Transplant
Stented Biliary Anastomosis in Living Donor Liver Transplantation
Determination of biliary complications in stented group compared to duct to duct anastomosis without stent
- Trial name
- NCT03636321
- Testing
- living donor liver transplantation with internal biliary stent
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alaa Mstafa Hassan Sewefy
Liver Disease
Portal Blood Flushes in the Peri-Reperfusion Stage of Liver Transplantation
By showing that increased levels of acidotic metabolites and electrolytes in the systemic blood of patients who do not receive portal blood flush prior to reperfusion compared to patients who do receive portal blood flush, and…
- Trial name
- NCT03563404
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Cytomegalovirus Infections
Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients
The purpose of this research study is to investigate whether or not oral maribavir is safe and effective compared to oral ganciclovir for preventing CMV disease when administered for up to 14 weeks in patients who have had a…
- Trial name
- NCT00497796
- Testing
- maribavir, ganciclovir
- Where
- 55 sites in United States
- Volunteers
- 307 people
- Sponsor
- Shire
Liver Transplant Disorder
Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant
Postreperfusion syndrome during living liver transplants remains a serious concern for transplant anesthesiologists. This syndrome is responsible for decreases in systemic blood pressure, systemic vascular resistance, and cardiac…
- Trial name
- NCT05277623
- Testing
- Mannitol, 0.9% normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Type 1 Diabetes
Bone Marrow vs Liver as Site for Islet Transplantation
The goal of this study is to evaluate safety and efficacy of bone marrow (BM) as site for pancreatic islet transplantationin humans.
- Trial name
- IsletBOM2 (NCT01722682)
- Testing
- Human pancreatic islet transplantation
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Ospedale San Raffaele
Liver Transplant, Liver Transplantation
Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation
The primary aim of this study is to determine whether a peripheral blood or graft lymphocyte phenotype of immune senescence or exhaustion is different between operationally tolerant and non-tolerant liver allograft recipients.
- Trial name
- OPTIMAL (NCT02533180)
- Testing
- Immunosuppression withdrawal
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hepatitis C, Renal Transplant
Peginterferon Alfa-2a Plus Ribavirin Combination Treatment in Chronic Hepatitis C Post-Renal Transplant Patients
There is a distinct lack of published literature on the effect of combination treatment of PEG-interferon and ribavirin on post-renal transplantation hepatitis C virus (HCV) patients.
- Trial name
- NCT00881582
- Testing
- Pegylated interferon alfa-2a plus ribavarin
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- King Abdulaziz Medical City
Liver Failure
Comparative FK506 Drug Levels of Once Daily Advagraf in First Nations and Caucasian Patients With Liver Transplants
Background: Previous studies have documented differences in the pharmacokinetics (PK) of a once daily FK506 formulation (Advagraf) based on patient ethnicity.
- Trial name
- NCT04237246
- Testing
- Tacrolimus
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Liver Transplantation
Biomarkers Predicting Successful Tacrolimus Withdrawal and Everolimus (Zortress) Monotherapy Early After Liver Transplantation
Most patients who get a liver transplant must take immunosuppressants for the rest of their lives. However, this has occurred at the expense of chronic CNI toxicity, e.g.
- Trial name
- NCT02736227
- Testing
- Tacrolimus Withdrawal and Everolimus Monotherapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Northwestern University
Liver Transplant Disorder
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
- Trial name
- NCT04031924
- Testing
- Assessment of: 1. Functional Capacity 2. Physical Fitness 3. Physical Activity Level 4. Balance 5. Kinesiophobia 6. Psychological Status 7. Fatigue Severity
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Liver Transplantation
Evaluation of Liver Disease With Elastography Measurements in Patients Undergoing Liver Transplant Surgery
The purpose of the study is to compare ultrasound measurements of the liver obtained prior to surgery on the skin to measurements obtained during surgery directly on the diseased liver.
- Trial name
- SupersonicOR (NCT01890460)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Renal Insufficiency, Acute
New Urine and Blood Markers for Acute Kidney Injury in Liver Transplant Patients
The purpose of this study is to find new blood and urine tests that detect acute kidney injury earlier than our current blood tests in patients receiving a liver transplant.
- Trial name
- NCT00855127
- Where
- 2 sites in United States
- Sponsor
- University of Colorado, Denver
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