Clinical trials: Transplantation, Liver
Liver Transplant; Complications, Liver Failure, Acute
Correlation of Blood Gene Expression (TruGraf Liver) With Liver Biopsy in Pediatric Liver Transplant Recipients
Liver transplant rejection is when the body's immune system attacks and damages the liver of a transplant recipient. Currently the best way to see if that is happening is with a liver biopsy.
- Trial name
- NCT06263114
- Testing
- TruGraf® Liver gene expression panel (GEP)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Mercy Hospital Kansas City
Liver Transplantation
Evaluation of Celsior® in Liver Transplant Preservation.
The aim of the study is to determine the efficacy and safety of a preservation solution in liver transplantation. Its efficacy will be compared to the efficacy of other currently used preservation solutions.
- Trial name
- NCT00151593
- Testing
- Celsior®
- Where
- 9 sites in France
- Volunteers
- 140 people
- Sponsor
- Rennes University Hospital
End Stage Liver DIsease
Disparities Among Liver Transplant Patients
The purpose of this study is to inform healthcare interventions to reduce the disparities in liver transplant listing and in transplantation.
- Trial name
- NCT05981196
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
End Stage Liver Disease, Hepatic Encephalopathy
Prediction of Mortality in Patients Waiting for Liver Transplantation Through Brain Magnetic Resonance Imaging
The purpose of this study is to determine whether hepatic encephalopathy, measured through magnetic resonance imaging, electroencephalogram and neuropsychological evaluation adds prognostic information to patients who are waiting…
- Trial name
- NCT01434056
- Where
- Brazil
- Volunteers
- 400 people
- Sponsor
- Hospital Israelita Albert Einstein
Liver Transplantation
Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA)
To provide continued access for the LLT system to provide additional safety data in support of the PILOT pivotal efficacy and safety trial
- Trial name
- PILOT™_CA (NCT05574361)
- Testing
- Hypothermic Machine Perfusion
- Where
- 5 sites in United States
- Volunteers
- 385 people
- Sponsor
- Organ Recovery Systems, Inc.
Renal Insufficiency
Safety Use of ATeGe in Liver Transplant Recipients With Pre-transplant Renal Dysfunction
Renal dysfunction in the context of liver transplantation is a major issue, with difficult patients' management and determining a worsened prognosis.
- Trial name
- ATG_HVH (NCT01453218)
- Testing
- ATeGe-Fresenius
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Vall d'Hebron
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Liver Preservation
Trial of the TransMedics Organ Care System™ Liver For Preserving and Assessing Donor Livers for Transplantation
A prospective, single-center controlled trial to evaluate the safety and performance of the portable Organ Care System (OCS) Liver for preservation and assessment of donor livers for transplantation.
- Trial name
- REVIVE (NCT02449694)
- Testing
- OCS Liver
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- TransMedics
Hepatitis B, Liver Transplantation
Evaluation of HepaGam B® in Combination With Antiviral Treatment in Hepatitis B Liver Transplant Patients
The purpose of the study is to assess the pharmacokinetics, safety and efficacy of HepaGam B in combination with antiviral therapy for the prevention of hepatitis B virus (HBV) recurrence following HBV-related orthotopic liver…
- Trial name
- NCT00722332
- Testing
- HepaGam B
- Where
- 16 sites in United States, Canada
- Volunteers
- 9 people
- Sponsor
- Cangene Corporation
Chronic Hepatitis C, Organ Transplantation
Randomized Controlled Trial in Liver Transplant Recipients Treated in Steroid Sparing Regimen
Liver transplant subjects will be given Mycophenolate (MMF) and Tacrolimus in order to help prevent post-transplant rejection.
- Conditions
- Chronic Hepatitis C, Organ Transplantation, Immunosuppression
- Trial name
- NCT00286871
- Testing
- Neoral, Tacrolimus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Liver Transplantation, Hepatocellular Carcinoma
Lenvatinib Therapy in HCC Patients After LDLT
New guidelines have been successfully established to distinguish the patients who were suitable for LT. This is important for long-term recurrence free and overall survival rate.
- Trial name
- NCT05572528
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaoshiung Chang Gung Memorial Hospital
Hepatocellular Carcinoma
The ImmunoXXL Study
This study is aimed at confirming data of efficacy and safety of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) beyond current transplant criteria who demonstrate a sustained partial or complete…
- Trial name
- ImmunoXXL (NCT05879328)
- Testing
- Liver Transplantation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Eating Disorders, Eating Disorder Binge
Study of Prevalence of Eating Disorder in Liver Transplant Patients
The main goal of this observational study is to measure the prevalence of binge eating disorder in liver transplant patients by evaluating the responses to the Bulimia Test.
- Conditions
- Eating Disorders, Eating Disorder Binge, Liver Transplant; Complications, Alcohol Use Disorder
- Trial name
- Pré-THETA (NCT06093919)
- Where
- 2 sites in France
- Volunteers
- 118 people
- Sponsor
- Centre Hospitalier Henri Laborit
Liver Transplantation
Pharmacokinetics of Tacrolimus in Liver Transplantation Patients Treated With Prograf and Modified Release Tacrolimus
Tacrolimus pharmacokinetics study in primary living donor liver transplantation patients with Tacrolimus based immunosuppressive regimens.
- Trial name
- NCT00909571
- Testing
- FK506E (modified release tacrolimus), Prograf (tacrolimus)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Astellas Pharma Inc
Hepatitis C Infection
Open Label Study of the Efficacy and Safety of MBL-HCV1 in Combination With Oral Direct-Acting Antivirals in Patients Undergoing Liver Transplantation for Hepatitis C
The purpose of this study is to assess efficacy of a human monoclonal antibody against Hepatitis C (MBL-HCV1) combined with telaprevir [part 1: an HCV protease inhibitor] or sofosbuvir [part 2: an Hepatitis C virus NS5B…
- Trial name
- MBL-HCV1 (NCT01532908)
- Testing
- MBL-HCV1, Telaprevir (Part 1), Sofosbuvir (Part 2)
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- MassBiologics
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Coronary Artery Disease, Acute Liver Failure
Cardiac Risk Assessment Using Standard of Care Versus CTA and Heart Flow FFRct
Coronary Artery Disease (CAD) is the narrowing or blockage of the artery of the heart and is prevalent in end-stage liver disease.
- Conditions
- Coronary Artery Disease, Acute Liver Failure, Liver Transplant
- Trial name
- CRASCH-Liver (NCT04089969)
- Testing
- CTA/FFRct, SOC cardiovascular evaluation
- Sponsor
- Corewell Health East
Liver Transplant; Complications
Proteinuria in Liver Transplantation, a Single Egyptian Center Study
Proteinuria has been suggested to be a predictive factor and an important tool for differentiating the etiology of renal dysfunction in various clinical scenarios .The good predictive performance of preoperative proteinuria…
- Trial name
- NCT05733754
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Osteoporosis, Liver Transplantation
The Effect of Zoledronic Acid on Bone Density in Liver Transplant Patients
Following liver transplantation, rapid bone loss occurs, particularly within the first 6 months post-transplant. This may be associated with fractures, most notable vertebral.
- Conditions
- Osteoporosis, Liver Transplantation, Fractures
- Trial name
- NCT00114556
- Testing
- zoledronic acid
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal Prince Alfred Hospital, Sydney, Australia
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