Clinical trials: Transplantation, Liver
Alcohol Associated Liver Disease, Liver Transplantation
ADDICTOlogical Intervention in LIVEr Transplantation Recipients
Transplantation for end-stage-liver disease (ESLD) in the context of Alcohol-Associated Liver Disease (AALD) has been increasing and represents the main indication for Liver Transplantation (LT) in the world.
- Trial name
- AddictoLIVE (NCT06472973)
- Testing
- Post-transplant addiction intervention
- Where
- 16 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Montpellier
Non-alcoholic Fatty Liver Disease
Intestinal Microbiota Transplantation for Nonalcoholic Fatty Liver Disease
In China, with the improvement of living standards, there is a significant increase in the rate of prevalence of type 2 diabetes and hyperlipidemia, associated with Non-alcoholic fatty liver disease（NAFLD） which has gradually…
- Trial name
- NAFLD (NCT03648086)
- Testing
- intestinal microbiota transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongshan Hospital Xiamen University
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Hepatocellular Carcinoma
Relationship Between 18FDG PET/MRI Patterns and ctDNA to Predict HCC Recurrence After Liver Transplantation
Liver transplantation is the standard treatment for patients with early-stage Hepatocellular Carcinoma (HCC). Currently, important treatment decisions, like the selection of patients for transplantation, are made on crude, static…
- Trial name
- PETMRIinHCC (NCT03839706)
- Testing
- PET MRI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Acute-On-Chronic Liver Failure, Liver Cirrhosis
Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study
The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology.
- Conditions
- Acute-On-Chronic Liver Failure, Liver Cirrhosis, Liver Transplant; Complications
- Trial name
- TEA-ACLF (NCT05036031)
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Liver Transplant Infection, Surgical Site Infection
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.
- Conditions
- Liver Transplant Infection, Surgical Site Infection, Antibiotic Prophylaxis, Cephazolin Adverse Reaction
- Trial name
- ProCeTH (NCT04280237)
- Testing
- Blood samples
- Where
- France
- Sponsor
- University Hospital, Tours
Liver Cirrhosis
Validation of the Bispectral Index Monitor During Living Donor Liver Transplantation
Bispectral index (BIS) monitoring during living donor liver transplantation (LDLT) may be influenced with several factors rather than the depth of anesthesia such as bradycardia, hypotension, hypothermia, and mixed venous oxygen…
- Trial name
- NCT01494220
- Testing
- Bispectral index monitoring (BIS)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Living Donor Liver Transplantation, Hypotension
Hypotension Prediction Index in Living Donor Liver Transplantation
The Hypotension Prediction Index via the Edwards Hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients.
- Trial name
- NCT05010941
- Testing
- Hypotension Prediction Index
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Liver Transplant; Complications, Vasoplegia
Angiotensin II in Liver Transplantation
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
- Trial name
- AngLT-1 (NCT04901169)
- Testing
- Angiotensin II, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Organ Preservation Solutions
Peri-operative rATG-perfusion of Solid Transplants
The increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs.
- Trial name
- ATG-perfusion (NCT03377283)
- Testing
- organ perfusion with rabbit anti-thymocyte globulin (rATG), organ perfusion with saline
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
Covid19, Liver Transplant
Liver Transplantation and Coronavirus Disease 2019 (COVID-19)
The COVID-19 pandemic together with the strategies that are applied to control it are generating high morbidity and mortality worldwide.
- Trial name
- NCT04695756
- Testing
- COVID-19 pandemic
- Where
- Argentina
- Volunteers
- 1,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Portal Vein Thrombosis, Liver Transplant; Complications
Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis
Data of demographic, clinical, laboratory and imaging studies of living donor liver transplantation (LDLT) recipients from two transplant centers were collected.
- Trial name
- NCT05132192
- Testing
- living donor liver transplantation, Thrombectomy or interposition graft
- Volunteers
- 335 people
- Sponsor
- Elvan Onur Kirimker
Liver Transplantation
Physical Activity and Fatigue in Caregivers Before and After Liver Transplantation
Caregivers of liver transplant recipients often experience substantial physical and psychological demands during the transplantation process.
- Trial name
- NCT07468812
- Testing
- Observational assessment of caregivers without any intervention.
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people
- Sponsor
- Hasan Kalyoncu University
Liver Transplantation, Portal Hypertension
Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantation
The goal of this clinical trial is to compare the effects of somatostatin and terlipressin on lowering portal pressure in patients with portal hypertension undergoing liver transplantation, and to investigate whether there are…
- Trial name
- NCT07304466
- Testing
- Somatostatin, Terlipressin
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medipol University Hospital
Liver Dysfunction
Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation
INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and outcomes.
- Trial name
- INTERLIVER (NCT03193151)
- Testing
- liver biopsy
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Liver Failure, Mesenchymal Stem Cell
MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation
Acute liver failure (ALF) refers to a potentially reversible disorder that was the result of severe liver injury, with an onset of encephalopathy within 8 weeks of symptom appearance and in the absence of pre-existing liver…
- Conditions
- Liver Failure, Mesenchymal Stem Cell, Extracellular Vesicles
- Trial name
- NCT06825572
- Testing
- MSC-EVs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Transplant
Hepato-duodenal Ligament Occlusion and Classic Technique in Liver Transplant
Liver transplantation was historically associated with massive blood loss. Many factors have contributed to the decline in bleeding and transfusion in the past two decades including refinement of surgical techniques, anesthetics…
- Trial name
- NCT04265157
- Testing
- Surgical technique surgical occlusion
- Volunteers
- 50 people
- Sponsor
- Assiut University
Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome
Ultrasound Elastography to Predict Development of SOS
The long-term goal of our research is to accurately identify SOS patients who would benefit from defibrotide treatment using US SWE. The overall objective of this study is to validate SWE as an early diagnostic marker for SOS.
- Conditions
- Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Stem Cell Transplant Complications
- Trial name
- NCT03858530
- Testing
- Ultrasound Examination
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Mercy Hospital Kansas City
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Transplantation
The Validity of Central Venous to Arterial Co2 Difference During Living Donor Liver Transplantation
Study will be conducted on 20 patients ASA III-IV undergoing orthotopic liver transplantation. Blood samples will be obtained simultaneously from arterial line, pulmonary artery catheter and central venous catheter at 4 specific…
- Trial name
- NCT03123172
- Testing
- arterial and central venous blood gases
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
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