Clinical trials: Transplantation, Liver
Diabetes, Insulin Resistance
Measurement of the Pancreas Function in Patients With More Than One Pancreas After Liver and Small Bowel Transplantation
Under chronic immunosuppressive and corticosteroid therapy, transplant patients have a tendency to develop in the long-term diabetes.
- Conditions
- Diabetes, Insulin Resistance, Liver/Small Bowel Transplant
- Trial name
- NCT01621516
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Alpha-1 Antitrypsin Deficiency
Alpha-1 Antitrypsin Deficiency Adult Liver Study
The investigators hypothesize that there is liver injury (inflammation, fibrosis, cirrhosis) in adults with Alpha-1 Antitrypsin Deficiency (AATD), which is asymptomatic, under-recognized, and undiagnosed.
- Trial name
- NCT02014415
- Testing
- Liver Biopsy (Biopsy Group Only)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- St. Louis University
Liver Transplantation, Clinical Registry
Institutional Registry of Liver Transplantation
The Institutional Registry of Liver Transplantation is a system for data collection related to patients with liver disease who are possible candidates for liver transplantion.
- Trial name
- IRLT (NCT02839616)
- Testing
- orthotopic liver transplantation
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Hospital El Cruce
Organ Transplant, Ischemic Reperfusion Injury
PERTRIAL - Perla® Preservation Solution
Perla® is a Cold Preservation Solution, with purpose to wash out, preserve during transport liver and kidney grafts in optimal conditions from the donor to the recipient.
- Trial name
- NCT05194306
- Testing
- Perla® Cold Preservation solution
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Advanced Life Solutions
Liver Transplant Abscess
Risk Factors and Outcomes of Pyogenic Liver Abscess in Adult Liver Recipients: A Match Case Control Study
Objective: the aim of this study is to identify risk factors associated with the development of pyogenic liver abscesses (PLA) in adult liver recipients (ALR) and to describe the experience of the Hospital Italiano de Buenos…
- Trial name
- NCT03064685
- Where
- Argentina
- Volunteers
- 126 people
- Sponsor
- Hospital Italiano de Buenos Aires
HCC, Liver Cirrhosis
SALT for Liver Cirrhosis With HCC
HCC is the third leading cause of cancer deaths worldwide. Although surgical treatment may be effective in patients with HCC, the five-year survival rate is only 50-70%.
- Trial name
- NCT06069947
- Testing
- sequential adult left lateral lobe liver transplantation (SALT)
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma, Liver Transplantation
Safety and Efficacy of PD-1 Inhibitors in Patients With Liver Transplant
This is a perspective clinical study to assess the safety and efficacy of PD-1 inhibitors in patients with LT. Eligible patients have recurrent or metastatic cancer after LT, are not amenable to, or refractory after, locoregional…
- Trial name
- NCT03966209
- Testing
- JS001(PD-1 inhibitor)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Allograft, Liver Diseases
Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe Year AfTer lIver transplantatiON (ALTERNATION)
The overall aim of this study is nephroprotection based on a calcineurin inhibitor (CNI)-free therapy beyond year one after orthotopic liver transplantation (OLT) in highly pre-selected patients with low rejection risk.
- Conditions
- Liver Allograft, Liver Diseases, Liver Transplantation
- Trial name
- ALTERNATION (NCT07739914)
- Testing
- Everolimus, Tacrolimus or Cyclosporine
- Where
- 16 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Hannover Medical School
Heparin-induced Thrombocytopenia, Liver Transplantation
Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients
In a prospective observational study the incidence of Heparin-induced Thrombocytopenia (HIT) Type 2 after orthotopic liver transplantation, associated factors, and hemostaseological findings in thrombocytes and anti-body patterns…
- Trial name
- HITOLT (NCT01654848)
- Where
- Germany
- Volunteers
- 39 people
- Sponsor
- CHIR-Net
Liver Cirrhosis, Fibrosis
Human Menstrual Blood-derived Mesenchymal Stem Cells for Patients With Liver Cirrhosis
Orthotopic liver transplantation (OLT) is currently the most effective method for end-stage liver diseases. However, the critical shortage of donor organs, high cost, and the problem of immune rejection limit its clinical…
- Conditions
- Liver Cirrhosis, Fibrosis, Liver Disease, Digestive System Disease
- Trial name
- NCT01483248
- Testing
- conventional therapy plus MenSC transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- S-Evans Biosciences Co., Ltd.
End Stage Liver DIsease, Liver Transplantation
Selection Protocol for Liver Transplantation in Patients Aged Over 70 Years
Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates…
- Conditions
- End Stage Liver DIsease, Liver Transplantation, Old Age
- Trial name
- Over70-LT (NCT06382740)
- Testing
- Liver transplantation
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Azienda Ospedaliera di Padova
Hepatitis B, Chronic
Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection
The purpose of this clinical research study is to learn if the study drug entecavir will prevent the recurrence of hepatitis B virus (HBV) in participants who receive an orthotopic liver transplant (OLT) due to HBV infection.
- Trial name
- NCT00395018
- Testing
- entecavir
- Where
- 32 sites in United States, Argentina and 7 more
- Volunteers
- 109 people
- Sponsor
- Bristol-Myers Squibb
Living Donor Liver Transplantation, Norepinephrine Bolus
Norepinephrine Boluses in Liver Transplantation
We study the efficacy of Norepinephrine boluses on prevention of postreperfusion syndrome during living donor liver transplantation.
- Conditions
- Living Donor Liver Transplantation, Norepinephrine Bolus, Postperfusion Syndrome
- Trial name
- NCT03773276
- Testing
- Norepinephrine boluses
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Liver Transplantation
Non-Invasive Assessment of Graft Fibrosis After Living Donor Liver Transplantation
The aim of this study is to compare prospectively the ability of MRE and Transient Elastography in detection and staging of allograft fibrosis in comparison to Liver biopsy in patients who underwent Living Donor Liver…
- Trial name
- NCT03176290
- Testing
- Fibro-α score = (1.35 (numeric constant) +AFP (IU ml-1) × 0.009584 + aspartate aminotransferase (AST)/alanine aminotransferase(ALT) × 0.243 - platelet count (×109 l-1) × 0.001624).
- Volunteers
- 31 people
- Sponsor
- Ain Shams University
Evidence of Liver Transplantation
Safety, Efficacy of Eglandin® in Living Donor Liver Transplanted Patient (PROVISION)
The purpose of this study is to evaluate superiority of Eglandin® (Alprostadil) 720㎍compared to 360㎍ in terms of safety, efficacy in living donor liver transplant patient, peak AST levels followed by Eglandin administration were…
- Trial name
- PROVISION (NCT02350218)
- Testing
- Eglandin
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Liver Diseases, Liver Fibrosis
Post-Treatment Follow-up Study for Liver Disease Subjects With or Without Cirrhosis After Receiving Emricasan or Placebo
A post-treatment follow-up observational study for liver disease subjects with or without liver cirrhosis after receiving emricasan or placebo. Subjects must have been enrolled in a prior IDN-6556 study to be eligible.
- Conditions
- Liver Diseases, Liver Fibrosis, Liver Cirrhosis, NASH Fibrosis
- Trial name
- NCT03479125
- Testing
- Ultrasound
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Liver Transplantation, Obesity
Prospective Pilot Study for the Evaluation of Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Liver Transplant Candidates
The goal of this pilot prospective interventional study is to evaluate the efficacy of endoscopic sleeve gastroplasty (ESG) in allowing obese subjects with the need of liver transplantation to reduce their BMI in order to enter…
- Conditions
- Liver Transplantation, Obesity, Bariatric Surgery
- Trial name
- ESGiTX (NCT05760235)
- Testing
- Endoscopic sleeve gastroplasty (ESG)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Tumor, Evidence of Liver Transplantation
Combination of Cryosurgery and NK Immunotherapy for Tumors in Transplanted Liver
The aim of this study is the safety and efficacy of cryosurgery plus natural killer(NK) immunotherapy to tumors in transplanted liver.
- Trial name
- NCT02849015
- Testing
- Cryosurgery, NK immunotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
End Stage Liver Disease
Functional Assessment in Liver Transplantation
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic…
- Trial name
- FrAILT (NCT03228290)
- Where
- 12 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of California, San Francisco
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
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