Clinical trials: Transplantation, Liver
Liver Cirrhosis
Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients With Decompensated Liver Cirrhosis
Although liver transplantation provide a option to cure patients suffering with decompensated liver cirrhosis this condition, lack of donors, postoperative complications, especially rejection, and high cost limit its application.
- Trial name
- NCT01342250
- Testing
- conventional therapy plus low dose hUC-MSCs treatment, conventional therapy plus medium dose hUC-MSCs treatment, conventional therapy plus high dose hUC-MSCs treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
End Stage Renal Disease, End Stage Liver Disease
Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors
This study utilizes a web-based application to help patients on the organ transplant waitlist communicate patient's need for a living donor via social media and provide interested potential donors the opportunity to engage with…
- Trial name
- NCT03803423
- Testing
- The Donor App
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Liver Cirrhosis
Cirrhosis, Effects of TRAnsplantation and Diabetes
This observational study is aimed at assessing insulin secretion and sensitivity by the use of a mathematical modeling from oral glucose tolerance test in subjects with liver cirrhosis undergoing orthotopic liver transplantation…
- Trial name
- CETRA (NCT02038517)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Acute Liver Failure
Plasma Exchange for Amanita Toxin-induced Acute Liver Failure
Retrospective evaluation of the value of additive therapeutic plasma exchange (PEX) compared to standard medical therapy (SMT) in Amanita toxin-associated acute liver failure in children and adolescents within the last 10 years…
- Trial name
- Amanita-Pex (NCT06187220)
- Testing
- Therapeutic Plasma Exchange (PEX)
- Where
- 6 sites in Germany, Italy and 3 more
- Volunteers
- 111 people
- Sponsor
- Hannover Medical School
Hepatocellular Carcinoma, Hepatocellular Cancer
Patients With Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide and is frequently diagnosed at an advanced stage, resulting in limited therapeutic options.
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Liver Diseases, Liver Cancer
- Trial name
- FORCE (NCT07690683)
- Testing
- Fecal microbiota transplantation performed via colonoscopy.
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Cirrhosis, Hepatocellular Carcinoma
Safety Study of Liver Natural Killer Cell Therapy for Hepatoma Liver Transplantation
The objective of this study is to evaluate feasibility and safety of the adoptive transfer of activated natural killer (NK) cells extracted from cadaveric donor liver graft perfusate for liver transplant recipients with…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Evidence of Liver Transplantation
- Trial name
- MIAMINK (NCT01147380)
- Testing
- Liver NK cell inoculation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seigo Nishida
Liver Transplantation
Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA (Enteric Coated Mycophenolic Acid) Following Liver Transplantation
This is an investigator initiated study at the University of California, Los Angeles (UCLA) funded by Novartis looking at using a combination of immunosuppressive drugs in liver transplant patients that are at risk of developing…
- Trial name
- NCT02123108
- Testing
- Basiliximab, Tacrolimus, Mycophenolic Acid
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, Los Angeles
Osteoporosis, Liver Transplantation
Osteoporosis in Children and Adults Following Liver Transplantation
This pilot project aims to 1) estimate the prevalence of osteoporosis in adults having undergone liver transplantation in childhood, and 2) identify risk factors for osteoporosis in this group. We aim to study 40 individuals.
- Trial name
- NCT00008788
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Research Resources (NCRR)
Liver Transplantation
Endotracheal Cardiac Output Monitor (ECOM) for Patients Undergoing Liver Transplantation
The purpose of this study is to determine whether the endotracheal cardiac output monitor (ECOM) is accurate and predictive in liver failure patients with hyperdynamic circulatory changes.
- Trial name
- NCT01299441
- Testing
- ECOM ETT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Hepatitis B Virus, Liver Transplant
To Evaluate the Efficacy and Safety of Tenofovir Alafenamide Conversion in Liver Transplant Patients
This clinical trial aims to confirm the efficacy and safety of Vemlia® tablets (Tenofovir alafenamide) in liver transplant patients with hepatitis B, focusing on their effects on renal function.
- Conditions
- Hepatitis B Virus, Liver Transplant, Renal Insufficiency
- Trial name
- NCT06589518
- Testing
- Tenofovir Alafenamide Citrate
- Volunteers
- 108 people
- Sponsor
- Jongman Kim
Non-alcoholic Fatty Liver Disease
Non-invasive Diagnosis of Non-alcoholic Steatohepatitis in Liver Transplant Recipients
The purpose of this study is is to use non-invasive diagnostic tests, Fibroscan and a simple blood test, to diagnose NASH in patients who undergo liver transplantation.
- Trial name
- NCT03128918
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Transplantation
Effect of Ramadan Fasting on Muslim Recipients After Living Donor Liver Transplantation
The study aimed to assess the possibility of Ramadan fasting and to start protocol of adapting immunosupression regiment and scheduled follow up for patients wishing to fast after liver transplantation (LT).
- Trial name
- NCT03592524
- Testing
- Fasting Ramadan
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Liver Transplantation
Unplanned ICU Readmission for Pediatric Liver Transplantation
To explore the risk factors of unplanned return to Intensive Care Unit (ICU) in pediatric liver transplant recipients, and to provide data support for the transfer of pediatric liver transplant recipients from ICU after surgery…
- Trial name
- NCT06162260
- Testing
- ICU readmission
- Volunteers
- 1,575 people
- Sponsor
- RenJi Hospital
Heart Transplantation, Kidney Transplantation, Liver Transplantation, Autoimmune Diseases
The Mycophenolate Pregnancy Registry
The Mycophenolate Pregnancy Registry is designed as a prospective, observational registry collecting data regarding mycophenolate exposure during pregnancy, and pregnancy outcomes, fetal and infant outcomes after exposure.
- Trial name
- NCT01733082
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Genentech, Inc.
Liver Transplant; Complications, NAFLD
Safety, Tolerability, and Efficacy of Saroglitazar Mg 4 mg in Liver Transplant Recipients With Nonalcoholic Fatty Liver Disease (NAFLD)
This is a phase 2A, single center, open-label, single-arm, 24-week study to evaluate the safety, tolerability and efficacy of Saroglitazar Magnesium 4 mg in liver transplant recipients with NAFLD.
- Trial name
- NCT03639623
- Testing
- Saroglitazar
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Zydus Therapeutics Inc.
Late Complication From Liver Transplant
Boceprevir Treatment in Liver Pre-transplant HCV Patients
End-stage liver disease due to hepatitis C virus (HCV) is the most common indication for liver transplantation(LT) worldwide (30~40%).
- Trial name
- NCT02160080
- Testing
- Boceprevir 800mg/TID+Pegylated interferon alfa+Ribavirin
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Hu Tsung-Hui
Liver Failure
Hepatocyte Transplantation in Liver Failure
The investigators research will examine the safety and efficacy of hepatocyte transplantation in the patient with acute liver failure without history of chronic disease.
- Trial name
- NCT00805610
- Testing
- Hepatocyte Transplantation
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Transplant
Pneumonia Vaccine in Liver Transplant Recipients: a Booster Strategy Using a Conjugate Vaccine
The trial will compare a group of patients whose immune system is primed with the pneumococcal conjugate vaccine and then given a boost with polysaccharide vaccine (prime-boost strategy) vs.
- Trial name
- NCT00152802
- Testing
- The polysaccharide vaccine Pneumovax (Merck-Frosst), The conjugate vaccine used will be Prevnar (Wyeth vaccines)
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University Health Network, Toronto
Kidney Transplantation, Liver Transplantation
Quality of Life in Pediatric Transplant Patients
The goal of this study is to compare parent and child perceptions of wellness and vulnerability in children who have undergone solid organ transplant.
- Conditions
- Kidney Transplantation, Liver Transplantation, Heart Transplantation
- Trial name
- NCT00678002
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Medical College of Wisconsin
Chronic Hepatitis C Virus (HCV) Infection
An Efficacy and Safety Study of Telaprevir in Patients With Genotype 1 Hepatitis C Infection After Liver Transplantation
The purpose of this study is to evaluate the effectiveness of telaprevir in combination with Peg-IFN-alfa-2a and ribavirin in stable liver transplant patients with chronic hepatitis C virus (HCV) genotype 1.
- Trial name
- REPLACE (NCT01571583)
- Testing
- Telaprevir, Pegylated interferon alfa-2a, Ribavirin
- Where
- 21 sites in Austria, Belgium and 4 more
- Volunteers
- 74 people
- Sponsor
- Janssen-Cilag International NV
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